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[CAS NO. 54197-31-8] R(+)-Methylindazone

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Catalog:	HY-12693
Brand:	MCE
CAS:	54197-31-8

Overview

MDL	MFCD00069295
Molecular Weight	357.23
Molecular Formula	C17H18Cl2O4
SMILES	O=C(O)COC1=CC2=C(C([C@@](C)(C3CCCC3)C2)=O)C(Cl)=C1Cl

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Oxid Med Cell Longev. 2022 Apr 19;2022:4608914.

Summary

R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels . R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) ^[1] ^[2] ^[3] .

In Vitro

IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins ^[1] ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 279.93 mM )

H ₂ O : 0.1 mg/mL ( 0.28 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7993 mL	13.9966 mL	27.9932 mL
5 mM	0.5599 mL	2.7993 mL	5.5986 mL
10 mM	0.2799 mL	1.3997 mL	2.7993 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.00 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90(6):779-98.
[2] Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72.
[3] Xiaoqin Fan, et al. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int J Oncol. 2015 Oct;47(4):1485-93.

Synonyms

Acetic acid, 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-

Acetic acid, [(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]-, (R)-

2-[[(2R)-6,7-Dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]acetic acid

(+)[(6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-5-indanyl)oxy]acetic acid

R(+)-IAA 94

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