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[CAS NO. 543700-68-1] BMS-433771
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-120632 |
| Brand: | MCE |
| CAS: | 543700-68-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 377.44 |
| Molecular Formula | C21H23N5O2 |
| SMILES | O=C(N(C1=C2C=CN=C1)CC3=NC4=CC=CC=C4N3CCCCO)N2C5CC5 |
Summary
IC50 & Target
EC50: 20 nM (RSV) [1]
In Vitro
In Vivo
BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: |
rodent models of RSV infection
[2]
(cotton rat and mice) |
| Dosage: | 1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat) |
| Administration: | oral, single or bid 4 days |
| Result: |
Had prophylactic efficacy via oral dosing in both animal models.
Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother
- [2] Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54.
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