[CAS NO. 546111-97-1] LitronesibRacemate

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Catalog:	HY-14846A
Brand:	MCE
CAS:	546111-97-1

Overview

MDL	-
Molecular Weight	511.70
Molecular Formula	C23H37N5O4S2
SMILES	CC(C)(C)C(N1C(C2=CC=CC=C2)(CNS(CCNCC)(=O)=O)SC(NC(C(C)(C)C)=O)=N1)=O

For research use only. We do not sell to patients.

Summary

Litronesib Racemate (LY2523355 Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5 ^[1] .

IC50 & Target

kinesin Eg5 ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 195.43 mM ; Need ultrasonic)

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Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9543 mL	9.7713 mL	19.5427 mL
5 mM	0.3909 mL	1.9543 mL	3.9085 mL
10 mM	0.1954 mL	0.9771 mL	1.9543 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] THERAPEUTIC AGENT FOR GLAUCOMA. Japanese Patent JP2006265107

Synonyms

Propanamide, N-[4-(2,2-dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl]amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-

N-[4-(2,2-Dimethyl-1-oxopropyl)-5-[[[[2-(ethylamino)ethyl]sulfonyl]amino]methyl]-4,5-dihydro-5-phenyl-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide

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