[CAS NO. 55-98-1] Busulfan
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PRODUCTS SPECIFICATIONS [55-98-1]
Catelog
HY-B0245
Brand
MCE
CAS
55-98-1
DESCRIPTION [55-98-1]
Overview
| MDL | MFCD00007562 |
|---|---|
| Molecular Weight | 246.30 |
| Molecular Formula | C6H14O6S2 |
| SMILES | CS(=O)(OCCCCOS(C)(=O)=O)=O |
For research use only. We do not sell to patients.
8 Publications Citing Use of MCE
- [1]Biomark Res. 2023 Jan 24;11(1):8.
- [2]J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
- [3]Exp Cell Res. 2020 Aug 1;393(1):112054.
- [4]Stem Cells Dev. 2020 Apr 15;29(8):475-487.
- [5]Stem Cells Dev. 2019 Oct 1;28(19):1322-1333.
- [6]Asian J Androl. Mar-Apr 2020;22(2):184-191.
- [7]Andrologia. 2020 Dec 23;e13927.
- [8]Ann Transplant. 2021 Jan 8;26:e928047.
Summary
In Vitro
Busulfan (120 μM; 24 h) incited a moderate p53 activation, but strong Erk, p38, and JNK phosphorylation, in a time-dependent manner
[1]
.
Busulfan (120 μM; 24 h) results in premature senescence in WI38 cells via the Erk and p38 MAPK pathway, reduces GSH and increases ROS production, but the production can be suppressed by NADPH oxidase
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | WI38 cells |
| Concentration: | 120 μM |
| Incubation Time: | 24 hours |
| Result: |
Incited a moderate p53 activation, but strong Erk, p38, and JNK phosphorylation, in a time-dependent manner.
Elicited an immediate up-regulation of p21 expression, which subsided by day 11. |
In Vivo
Busulfan (40 mg/kg; i.p; single dose) increases apoptosis and decreases the testis weight in mice
[4]
.
Busulfan (2.5, 5.0 mg/kg, i.p.) causes earlier occurrence of persistent esturs in a dose dependent manner in rats. Busulfan (5.0 mg/kg) also increases the incidence of uterine adenocarcinomas and multiplicity of uterine neoplastic lesions
[5]
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | ICR male mice ranging in age from 8 to 12 weeks (30-40 g) [4] |
| Dosage: | 40 mg/kg (in sesame oil) |
| Administration: | IP; single dose |
| Result: |
Increased apoptosis and decreased the testis weight in mice.
Exhibited higher level of pRB expression, inhibited Rb phosphorylation and PCNA expression compared to the control. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02701673 | M.D. Anderson Cancer Center |
Lymphoma
|
June 2016 | Phase 1|Phase 2 |
| NCT01605032 | Albert Einstein College of Medicine|National Cancer Institute (NCI) |
DS Stage I Plasma Cell Myeloma|DS Stage II Plasma Cell Myeloma|DS Stage III Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
|
February 2012 | Phase 2 |
| NCT02061800 | Diane George|Columbia University |
Chronic Myeloid Leukemia (CML)|Acute Myelogenous Leukemia (AML)|Myelodysplastic Syndrome (MDS)|Juvenile Myelomonocytic Leukemia (JMML)|Acute Lymphoblastic Leukemia (ALL)|Lymphoma (Hodgkin´s and Non-Hodgkin´s)
|
June 3, 2013 | Phase 1|Phase 2 |
| NCT03674411 | Masonic Cancer Center, University of Minnesota |
Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Biphenotypic+Undifferentiated Leukemia|Chronic Myelogenous Leukemia|Myelodysplasia|Relapsed Large Cell Lymphoma|Mantle Cell Lymphoma|Hodgkin Lymphoma|Burkitt Lymphoma|Relapsed T-Cell Lymphoma|Lymphoplasmacytic Lymphoma
|
January 2, 2019 | Phase 2 |
| NCT00053196 | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma|Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myeloproliferative Neoplasms
|
December 2002 | Phase 2 |
| NCT00588523 | Memorial Sloan Kettering Cancer Center|University of Calgary|Northwestern University|Northwestern Memorial Hospital|Massachusetts General Hospital|Schering-Plough |
CNS Cancer|CNS BRAIN
|
September 2002 | Phase 2 |
| NCT05449899 | Nanfang Hospital of Southern Medical University|Peking University People´s Hospital|Institute of Hematology and Blood Diseases Hospital|Guangzhou First People´s Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|First People´s Hospital of Chenzhou|The Seventh Affiliated Hospital of Sun Yat-sen University |
Secondary Acute Myeloid Leukemia Evolving From MDS|Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning
|
July 2022 | Phase 2|Phase 3 |
| NCT00003101 | Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) |
Brain and Central Nervous System Tumors
|
August 1997 | Phase 2 |
| NCT00002989 | European Organisation for Research and Treatment of Cancer - EORTC|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
March 1997 | Phase 3 |
| NCT00496340 | H. Lee Moffitt Cancer Center and Research Institute |
Hematologic Malignancies
|
July 2007 | Phase 2 |
| NCT00049634 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
January 2002 | Phase 1|Phase 2 |
| NCT02410551 | M.D. Anderson Cancer Center|CTI BioPharma |
Myeloproliferative Diseases
|
June 15, 2015 | Phase 2 |
| NCT00782379 | Northside Hospital, Inc. |
Leukemia|Lymphoma|Myelodysplastic Syndromes
|
October 2008 | Phase 2 |
| NCT00002701 | European Organisation for Research and Treatment of Cancer - EORTC|Gruppo Italiano Malattie EMatologiche dell´Adulto|National Cancer Institute (NCI) |
Leukemia
|
October 1995 | Phase 3 |
| NCT00322101 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) |
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Acute Myeloid Leukemia+Transient Myeloproliferative Disorder|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Childhood Acute Myeloid Leukemia in Remission|Childhood Myelodysplastic Syndromes|de Novo Myelodysplastic Syndromes|Myelodysplastic Syndrome With Isolated Del(5q)|Myelodysplastic+Myeloproliferative Neoplasm, Unclassifiable|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes
|
January 2006 | Phase 3 |
| NCT00446173 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Leukemia
|
March 2007 | Phase 2 |
| NCT05170828 | Ossium Health, Inc.|Center for International Blood and Marrow Transplant Research |
Acute Leukemia|Myelodysplastic Syndromes|T-lymphoblastic Lymphoma|Acute Lymphocytic Leukemia|Acute Myeloid Leukemia|Acute Biphenotypic Leukemia|Acute Undifferentiated Leukemia
|
March 2022 | Phase 1 |
| NCT00006054 | Fairview University Medical Center|Office of Rare Diseases (ORD) |
Immunologic Deficiency Syndromes|Chediak-Higashi Syndrome|Common Variable Immunodeficiency|Graft Versus Host Disease|X-Linked Lymphoproliferative Syndrome|Familial Erythrophagocytic Lymphohistiocytosis|Hemophagocytic Lymphohistiocytosis|X-linked Agammaglobulinemia|Wiskott-Aldrich Syndrome|Chronic Granulomatous Disease|X-linked Hyper IgM Syndrome|Severe Combined Immunodeficiency|Leukocyte Adhesion Deficiency Syndrome|Virus-Associated Hemophagocytic Syndrome
|
March 2000 | Not Applicable |
| NCT00002549 | European Organisation for Research and Treatment of Cancer - EORTC|National Cancer Institute (NCI) |
Leukemia
|
November 1993 | Phase 3 |
| NCT02441803 | M.D. Anderson Cancer Center |
Leukemia
|
September 14, 2015 | Phase 2 |
| NCT05027945 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
Immunodeficiency|Hematopoietic Stem Cell Transplantation
|
November 28, 2022 | Phase 2 |
| NCT01572181 | Nantes University Hospital |
Hematologic Malignancy
|
April 2012 | Phase 2 |
| NCT00787761 | Northside Hospital, Inc.|Blood and Marrow Transplant Group of Georgia |
Myeloproliferative Disorders|Kidney Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
April 2007 | Phase 2 |
| NCT01685411 | Masonic Cancer Center, University of Minnesota |
Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome
|
January 2013 | Not Applicable |
| NCT03303950 | University of Utah |
Anemia|ASXL1 Gene Mutation|EZH2 Gene Mutation|IDH1 Gene Mutation|IDH2 Gene Mutation|Plasma Cell Myeloma|Primary Myelofibrosis|Recurrent Plasma Cell Myeloma|Secondary Myelofibrosis|Thrombocytopenia
|
March 30, 2018 | Phase 2 |
| NCT01156350 | University Hospital, Clermont-Ferrand |
Neuroblastoma
|
September 2011 | Phase 2 |
| NCT00506857 | M.D. Anderson Cancer Center |
Hematologic Malignancies
|
November 2003 | Phase 1|Phase 2 |
| NCT05466318 | Sichuan University |
Lymphoma, Large B-Cell, Diffuse|Lymphoma, T-Cell
|
July 1, 2022 | Phase 3 |
| NCT03128359 | City of Hope Medical Center|National Cancer Institute (NCI) |
Acute Leukemia|Chronic Lymphocytic Leukemia+Small Lymphocytic Lymphoma|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Diffuse Large B-Cell Lymphoma|Follicular Lymphoma|Graft Versus Host Disease|Hodgkin Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma|Secondary Myelodysplastic Syndrome
|
May 30, 2017 | Phase 2 |
| NCT00800839 | M.D. Anderson Cancer Center |
Hematologic Diseases|Leukemia|Lymphoma|Myeloma
|
September 2008 | Phase 2 |
| NCT02143830 | Children´s Hospital Medical Center, Cincinnati|Memorial Sloan Kettering Cancer Center|Fred Hutchinson Cancer Center |
Fanconi Anemia|Severe Marrow Failure|Myelodysplastic Syndrome (MDS)|Acute Myelogenous Leukemia (AML)
|
April 2014 | Phase 2 |
| NCT00669890 | New York Medical College |
Acute Myeloid Leukemia|Juvenile Myelomonocytic Leukemia|Myelodysplastic Syndrome
|
May 2004 | Phase 1 |
| NCT01421173 | M.D. Anderson Cancer Center |
Lymphoma
|
August 2011 | Phase 1 |
| NCT00679536 | Ann & Robert H Lurie Children´s Hospital of Chicago |
Leukemia
|
May 2008 | Phase 1|Phase 2 |
| NCT00003199 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Estrogen Receptor-negative Breast Cancer|Estrogen Receptor-positive Breast Cancer|Inflammatory Breast Cancer|Male Breast Cancer|Progesterone Receptor-negative Breast Cancer|Progesterone Receptor-positive Breast Cancer|Stage IIIB Breast Cancer|Stage IV Breast Cancer
|
November 1997 | Phase 2 |
| NCT00547196 | City of Hope Medical Center|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Myelodysplastic Syndromes
|
August 16, 2005 | Not Applicable |
| NCT00002831 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Leukemia
|
August 1, 1995 | Phase 1|Phase 2 |
| NCT00941720 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Multiple Myeloma and Plasma Cell Neoplasm
|
June 11, 2009 | Phase 2 |
| NCT02766465 | Medical College of Wisconsin|National Heart, Lung, and Blood Institute (NHLBI)|Blood and Marrow Transplant Clinical Trials Network|Dana-Farber Cancer Institute|National Marrow Donor Program|Emory University |
Sickle Cell Disease
|
November 2016 | Phase 2 |
| NCT05569512 | John Horan, MD|GlycoMimetics Incorporated|Dana-Farber Cancer Institute |
Acute Myeloid Leukemia|Pediatric Cancer
|
October 6, 2022 | Phase 1|Phase 2 |
| NCT00029380 | National Heart, Lung, and Blood Institute (NHLBI) |
Hematologic Diseases|Anemia, Sickle Cell|Beta-Thalassemia|Hematopoietic Stem Cell Transplantation
|
January 1999 | Phase 2 |
| NCT00034528 | National Institute of Allergy and Infectious Diseases (NIAID) |
Hemoglobinopathies|Anemia, Sickle Cell|Hemoglobin SC Disease|Thalassemia|Thalassemia Major
|
September 2001 | Phase 2 |
| NCT00334672 | Children´s Cancer and Leukaemia Group|National Cancer Institute (NCI) |
Nonneoplastic Condition
|
March 2006 | Phase 3 |
| NCT02310997 | University College, London|Cancer Research UK |
Leukaemia|Lymphoma|Other Haematological Diseases
|
July 2011 | Phase 2 |
| NCT00416598 | National Cancer Institute (NCI) |
Acute Myeloid Leukemia|Acute Myeloid Leukemia With Myelodysplasia-Related Changes|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A|Untreated Adult Acute Myeloid Leukemia
|
November 15, 2006 | Phase 2 |
| NCT00881556 | Columbia University |
Epidermolysis Bullosa
|
August 20, 2009 | Early Phase 1 |
| NCT02724163 | University of Birmingham|Assistance Publique - Hôpitaux de Paris|Cancer Research UK|National Cancer Institute, France|Pfizer |
Acute Myeloid Leukaemia
|
April 2016 | Phase 3 |
| NCT00043810 | M.D. Anderson Cancer Center |
Acute Myelogenous Leukemia|Myelodysplastic Syndrome
|
July 2002 | Phase 1|Phase 2 |
| NCT00612716 | Masonic Cancer Center, University of Minnesota |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm
|
October 6, 1999 | Phase 2 |
| NCT01823198 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Erythroid Leukemia|Acute Megakaryoblastic Leukemia|Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia in Remission|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Blasts Under 20 Percent of Bone Marrow Nucleated Cells|Blasts Under 20 Percent of Peripheral Blood White Cells|Chronic Myelomonocytic Leukemia|High Risk Myelodysplastic Syndrome|Myelodysplastic Syndrome|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Therapy-Related Acute Myeloid Leukemia|Therapy-Related Myelodysplastic Syndrome
|
June 11, 2013 | Phase 1|Phase 2 |
| NCT00684255 | New York Medical College |
Systemic Lupus Erythematosus|Systemic Sclerosis
|
August 2007 | Phase 1 |
| NCT03240861 | Jonsson Comprehensive Cancer Center|California Institute for Regenerative Medicine (CIRM) |
HLA-A*0201 Positive Cells Present|Locally Advanced Malignant Neoplasm|NY-ESO-1 Positive|Unresectable Malignant Neoplasm|Sarcoma
|
July 26, 2017 | Phase 1 |
| NCT00934232 | Guido Tricot|Otsuka Pharmaceutical Development & Commercialization, Inc.|University of Iowa |
Multiple Myeloma
|
August 2009 | Phase 1 |
| NCT00448357 | UNC Lineberger Comprehensive Cancer Center|National Cancer Institute (NCI)|Otsuka America Pharmaceutical |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
October 2005 | Phase 1|Phase 2 |
| NCT01702831 | University Health Network, Toronto|Princess Margaret Hospital, Canada|Otsuka Pharmaceutical Development & Commercialization, Inc.|Celgene Corporation |
Multiple Myeloma
|
October 1, 2013 | Phase 2 |
| NCT01027000 | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI)|Genentech, Inc.|Biologics, Inc. |
Leukemia|Lymphoma
|
February 2010 | Phase 2 |
| NCT00002502 | Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
July 1992 | Phase 2 |
| NCT01857934 | St. Jude Children´s Research Hospital|Cookies for Kids´ Cancer|CURE Childhood Cancer, Inc. |
Neuroblastoma
|
July 5, 2013 | Phase 2 |
| NCT00290628 | Masonic Cancer Center, University of Minnesota|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Diamond-blackfan Anemia|Fanconi Anemia|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
October 1999 | Not Applicable |
| NCT00024193 | Children´s Cancer and Leukaemia Group|Societe Francaise Oncologie Pediatrique|National Cancer Institute (NCI) |
Neuroblastoma
|
April 1999 | Phase 2 |
| NCT00579111 | Baylor College of Medicine|Center for Cell and Gene Therapy, Baylor College of Medicine|The Methodist Hospital Research Institute |
Myelodysplastic and Myeloproliferative Disorders|Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia|Multiple Myeloma|Plasma Cell Dyscrasia|Lymphoproliferative Disorders|Hematologic Diseases
|
June 2007 | Phase 1|Phase 2 |
| NCT01916252 | PETHEMA Foundation|Janssen, LP|Celgene|Pierre Fabre Medicament |
Multiple Myeloma
|
September 2013 | Phase 3 |
| NCT00004231 | Northwestern University|National Cancer Institute (NCI) |
Lymphoma
|
October 1999 | Phase 2 |
| NCT01306019 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
X-linked Severe Combined Immunodeficiency (XSCID)
|
September 25, 2012 | Phase 1|Phase 2 |
| NCT00801931 | Columbia University |
Leukemia|Lymphoma|Neuroblastoma|Immunodeficiencies|Anemia
|
September 6, 2007 | Phase 1|Phase 2 |
| NCT01279616 | Nationwide Children´s Hospital |
Sickle Cell Disease
|
September 2010 | Phase 2 |
| NCT00691015 | Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
May 2008 | Phase 2 |
| NCT03538899 | University of California, San Francisco |
Severe Combined Immunodeficiency
|
May 31, 2018 | Phase 1|Phase 2 |
| NCT01961063 | City of Hope Medical Center |
AIDS-related Non-Hodgkin Lymphoma|AIDS-related Plasmablastic Lymphoma|AIDS-related Primary Effusion Lymphoma|HIV Infection
|
December 31, 2015 | Phase 1 |
| NCT02859402 | Keimyung University Dongsan Medical Center|Otsuka Pharmaceutical Co., Ltd. |
T-cell Non-Hodgkin Lymphoma|Lymphoma, Extranodal NK-T-Cell
|
December 2016 | Phase 2 |
| NCT01020734 | Asan Medical Center |
Leukemia
|
May 2011 | Phase 2 |
| NCT01734850 | Calimmune, Inc. |
Human Immunodeficiency Virus
|
April 2013 | Phase 1|Phase 2 |
| NCT00540995 | City of Hope Medical Center |
Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Blastic Phase Chronic Myelogenous Leukemia|Childhood Acute Myeloid Leukemia in Remission|Childhood Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts
|
June 11, 2007 | Phase 1|Phase 2 |
| NCT00003619 | Drexel University College of Medicine|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic Syndromes|Thrombocytopenia
|
February 1998 | Phase 1|Phase 2 |
| NCT00578643 | Baylor College of Medicine |
Chronic Granulomatous Disease
|
March 2004 | Phase 2 |
| NCT00005797 | H. Lee Moffitt Cancer Center and Research Institute|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Multiple Myeloma and Malignant Plasma Cell Neoplasms|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
March 1993 | Phase 2 |
| NCT04123392 | Nanfang Hospital of Southern Medical University|Peking University People´s Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University|Zhujiang Hospital |
TP53|Myeloid Tumors|Conditioning|Allogeneic Hematopoietic Stem Cell Transplantation
|
October 2019 | Phase 2|Phase 3 |
| NCT03910452 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Chronic Granulomatous Disease
|
October 28, 2019 | Early Phase 1 |
| NCT00475020 | M.D. Anderson Cancer Center |
Myelofibrosis
|
January 4, 2006 | Phase 2 |
| NCT02057770 | Washington University School of Medicine |
Leukemia, Myeloid, Acute
|
February 28, 2014 | Phase 1 |
| NCT01983969 | M.D. Anderson Cancer Center |
Advanced Cancers|Lymphoma
|
November 7, 2013 | Phase 1|Phase 2 |
| NCT00363467 | H. Lee Moffitt Cancer Center and Research Institute|ESP Pharma |
Acute Myeloid Leukemia (AML)
|
May 2006 | Not Applicable |
| NCT00534430 | City of Hope Medical Center|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes
|
February 29, 2000 | Phase 2 |
| NCT00513474 | Massachusetts General Hospital |
Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
January 2008 | Phase 1 |
| NCT04945096 | The First Affiliated Hospital of Soochow University |
Engraft Failure|Relapse|GVHD
|
July 1, 2021 | Phase 3 |
| NCT03339700 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran |
Acute Lymphoblastic Leukemia, Adult
|
September 15, 2018 | Phase 2 |
| NCT03733327 | Nanfang Hospital of Southern Medical University|Peking University People´s Hospital|Guangzhou First People´s Hospital|Zhujiang Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University |
Primary Central Nervous System Lymphoma|Autologous Hematopoietic Stem Cell Transplantation|Conditioning
|
November 2018 | Phase 2|Phase 3 |
| NCT00822770 | M.D. Anderson Cancer Center|Genzyme, a Sanofi Company |
Stem Cell Transplantation|Leukemia
|
January 2009 | Phase 1|Phase 2 |
| NCT03600909 | Memorial Sloan Kettering Cancer Center|Pediatric Brain Tumor Consortium |
Fanconi Anemia|Myelodysplastic Syndrome (MDS)|Acute Myelogenous Leukemia (AML)
|
May 15, 2018 | Phase 2 |
| NCT02577094 | Nantes University Hospital|Gilead Sciences|Institut Cancerologie de l´Ouest |
Lymphocyte B CD22 Positive Acute Lymphoblastic Leukemia
|
Phase 1|Phase 2 | |
| NCT03970096 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Acute Biphenotypic Leukemia|Acute Leukemia of Ambiguous Lineage|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Acute Undifferentiated Leukemia|Blastic Plasmacytoid Dendritic Cell Neoplasm|Lymphoblastic Lymphoma|Mixed Phenotype Acute Leukemia|Acute Leukemia|Hematopoietic and Lymphoid Cell Neoplasm
|
November 19, 2019 | Phase 2 |
| NCT00014469 | Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) |
Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
December 2000 | Phase 2 |
| NCT00313625 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Multiple Myeloma and Plasma Cell Neoplasm
|
September 2005 | Phase 2 |
| NCT00005948 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Leukemia
|
January 2000 | Phase 2 |
| NCT02025881 | Gustave Roussy, Cancer Campus, Grand Paris |
High-risk Medulloblastoma
|
September 14, 2013 | Phase 1|Phase 2 |
| NCT01629511 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Allogeneic Hematopoietic Stem Cell Transplantation Recipient|Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Richter Syndrome
|
November 21, 2012 | Phase 1|Phase 2 |
| NCT00003926 | Masonic Cancer Center, University of Minnesota |
Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Chordoma|Kidney Cancer|Liver Cancer|Neuroblastoma|Ovarian Cancer|Retinoblastoma|Sarcoma
|
November 1998 | Phase 1 |
| NCT00469014 | M.D. Anderson Cancer Center|Genzyme, a Sanofi Company |
Acute Myeloid Leukemia|Myelodysplastic Syndrome|Chronic Myeloid Leukemia
|
September 2006 | Phase 2 |
| NCT04009525 | First Affiliated Hospital of Guangxi Medical University|Peking University People´s Hospital|Ruijin Hospital|The 923th Hospital of People´s Liberation Army|Fourth Affiliated Hospital of Guangxi Medical University|Liuzhou General Hospital|Hainan General Hospital|The Affiliated Hospital Of Guizhou Medical University|The First People´s Hospital of Yunnan |
Thalassemia Major
|
June 1, 2019 | Phase 4 |
| NCT05453552 | Nanfang Hospital of Southern Medical University|Peking University People´s Hospital|Institute of Hematology and Blood Diseases Hospital|Guangzhou First People´s Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|First People´s Hospital of Chenzhou|The Seventh Affiliated Hospital of Sun Yat-sen University |
Myelodysplastic Syndrome|Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning
|
July 2022 | Phase 2|Phase 3 |
| NCT01413178 | M.D. Anderson Cancer Center|Otsuka Pharmaceutical Development & Commercialization, Inc. |
Myeloma
|
September 30, 2011 | Phase 3 |
| NCT00008190 | Herbert Irving Comprehensive Cancer Center|National Cancer Institute (NCI) |
Leukemia
|
March 1999 | Phase 2 |
| NCT00802568 | Institut Paoli-Calmettes|National Cancer Institute (NCI) |
Multiple Myeloma and Plasma Cell Neoplasm
|
April 2007 | Phase 2 |
| NCT02130869 | St. Jude Children´s Research Hospital |
Neuroblastoma|Lymphoma|High-risk Tumor
|
October 10, 2014 | Phase 1 |
| NCT00093587 | Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) |
Graft Versus Host Disease|Leukemia
|
August 2004 | Not Applicable |
| NCT03596892 | Nanfang Hospital of Southern Medical University|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Guangzhou First People´s Hospital|Peking University People´s Hospital|Zhujiang Hospital|Third Affiliated Hospital, Sun Yat-Sen University |
Allogeneic Hematopoietic Stem Cell Transplantation|Conditions|Mixed-lineage-leukemia (MLL)-Rearranged Acute Leukemia
|
July 2018 | Phase 2|Phase 3 |
| NCT01471067 | M.D. Anderson Cancer Center|American Stem Cell, Inc.|National Cancer Institute (NCI) |
Blood And Marrow Transplantation|Leukemia|Lymphoma|Transplantation Infection|Transplantation, Bone Marrow
|
July 13, 2012 | Phase 1 |
| NCT00027937 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
|
August 2001 | Phase 2 |
| NCT02333838 | Assistance Publique - Hôpitaux de Paris |
Leukemia, Myeloid
|
May 2015 | Phase 2 |
| NCT00176930 | Masonic Cancer Center, University of Minnesota |
Leukemia, Myeloid, Chronic|AML|Leukemia, Lymphocytic, Acute|MDS|Leukemia, Lymphocytic, Chronic|JMML|Hodgkin´s Disease|Non-hodgkin´s Lymphoma|Multiple Myeloma
|
October 2001 | Not Applicable |
| NCT00598481 | Orchard Therapeutics |
Immunologic Deficiency Syndromes
|
October 2, 2002 | Phase 2 |
| NCT03171831 | First Affiliated Hospital of Guangxi Medical University |
Thalassemia Major
|
April 1, 2017 | Phase 4 |
| NCT00003462 | Duke University|National Cancer Institute (NCI) |
Brain and Central Nervous System Tumors
|
April 1998 | Phase 1 |
| NCT00357396 | Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) |
Sarcoma
|
June 2005 | Phase 2 |
| NCT00004128 | European Organisation for Research and Treatment of Cancer - EORTC|Gruppo Italiano Malattie EMatologiche dell´Adulto|National Cancer Institute (NCI) |
Leukemia
|
September 1999 | Phase 3 |
| NCT00176839 | Masonic Cancer Center, University of Minnesota |
Leukemia, Lymphocytic, Acute|AML|MDS
|
June 7, 2000 | Phase 2|Phase 3 |
| NCT01464359 | Masonic Cancer Center, University of Minnesota |
Acute Myelogenous Leukemia|Refractory Acute Myelogenous Leukemia
|
October 2011 | Phase 2 |
| NCT02034630 | Seoul National University Hospital |
Genetic Rare Disease
|
July 21, 2014 | Phase 1|Phase 2 |
| NCT03385096 | Nanfang Hospital of Southern Medical University|Guangzhou First People´s Hospital|Zhujiang Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University |
Autologous Hematopoietic Stem Cell Transplantation|Conditioning|Multiple Myeloma
|
January 2, 2018 | Phase 2|Phase 3 |
| NCT00578344 | Tami D. John|Baylor College of Medicine|The Methodist Hospital Research Institute |
Sickle Cell Disease|Hemoglobin SC
|
July 2005 | Not Applicable |
| NCT00950846 | Baylor College of Medicine|Center for Cell and Gene Therapy, Baylor College of Medicine |
Congenital Pediatric Disorders
|
September 2009 | Not Applicable |
| NCT00081055 | Mesoblast International Sàrl|National Cancer Institute (NCI)|Mesoblast, Ltd. |
Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes
|
Phase 2 | |
| NCT01020539 | Columbia University |
Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Juvenile Myelomonocytic Leukemia
|
September 11, 2002 | Phase 1 |
| NCT01009840 | Otsuka Pharmaceutical Development & Commercialization, Inc. |
Multiple Myeloma
|
May 2010 | Phase 2 |
| NCT02472392 | University of Louisville |
EWINGS SARCOMA
|
April 2013 | Phase 1 |
| NCT00426517 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Inherited Immune Deficiencies
|
January 19, 2007 | Early Phase 1 |
| NCT01044745 | University of Nebraska|National Cancer Institute (NCI) |
Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Contiguous Stage II Adult Burkitt Lymphoma|Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Contiguous Stage II Adult Lymphoblastic Lymphoma|Contiguous Stage II Grade 1 Follicular Lymphoma|Contiguous Stage II Grade 2 Follicular Lymphoma|Contiguous Stage II Grade 3 Follicular Lymphoma|Contiguous Stage II Mantle Cell Lymphoma|Contiguous Stage II Marginal Zone Lymphoma|Contiguous Stage II Small Lymphocytic Lymphoma|de Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Graft Versus Host Disease|Nodal Marginal Zone B-cell Lymphoma|Noncontiguous Stage II Adult Burkitt Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Grade 3 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia+Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Relapsing Chronic Myelogenous Leukemia|Secondary Myelodysplastic Syndromes|Splenic Marginal Zone Lymphoma|Stage I Adult Burkitt Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Mixed Cell Lymphoma|Stage I Adult Diffuse Small Cleaved Cell Lymphoma|Stage I Adult Immunoblastic Large Cell Lymphoma|Stage I Adult Lymphoblastic Lymphoma|Stage I Adult T-cell Leukemia+Lymphoma|Stage I Chronic Lymphocytic Leukemia|Stage I Cutaneous T-cell Non-Hodgkin Lymphoma|Stage I Grade 1 Follicular Lymphoma|Stage I Grade 2 Follicular Lymphoma|Stage I Grade 3 Follicular Lymphoma|Stage I Mantle Cell Lymphoma|Stage I Marginal Zone Lymphoma|Stage I Mycosis Fungoides+Sezary Syndrome|Stage I Small Lymphocytic Lymphoma|Stage II Adult T-cell Leukemia+Lymphoma|Stage II Chronic Lymphocytic Leukemia|Stage II Cutaneous T-cell Non-Hodgkin Lymphoma|Stage II Mycosis Fungoides+Sezary Syndrome|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia+Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Mycosis Fungoides+Sezary Syndrome|Stage III Small Lymphocytic Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia+Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides+Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Adult Acute Myeloid Leukemia|Waldenström Macroglobulinemia
|
December 2009 | Phase 2 |
| NCT00943319 | University of Chicago |
Leukemia|Lymphoma|Myeloma
|
March 2012 | Phase 1|Phase 2 |
| NCT01643668 | Massachusetts General Hospital |
Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome
|
July 2012 | Phase 2 |
| NCT00007995 | Herbert Irving Comprehensive Cancer Center|National Cancer Institute (NCI) |
Multiple Myeloma and Plasma Cell Neoplasm
|
July 1999 | Phase 2 |
| NCT01237951 | M.D. Anderson Cancer Center |
Myeloma
|
November 8, 2010 | Phase 2 |
| NCT03229616 | Nanfang Hospital of Southern Medical University|Guangzhou First People´s Hospital|Zhujiang Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University|Peking University People´s Hospital |
Autologous Hematopoietic Stem Cell Transplantation|Diffuse Large B-cell Lymphoma|Conditioning
|
July 5, 2017 | Phase 2|Phase 3 |
| NCT00003146 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Multiple Myeloma and Plasma Cell Neoplasm
|
November 1997 | Phase 2 |
| NCT02999984 | University of California, Los Angeles|California Institute for Regenerative Medicine (CIRM)|Orchard Therapeutics |
Severe Combined Immunodeficiency Due to ADA Deficiency
|
December 16, 2016 | Phase 1|Phase 2 |
| NCT04713956 | Nanfang Hospital of Southern Medical University|Peking University People´s Hospital|Institute of Hematology and Blood Diseases Hospital|Guangzhou First People´s Hospital|Third Affiliated Hospital, Sun Yat-Sen University|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|First People´s Hospital of Chenzhou|First Affiliated Hospital of Guangxi Medical University |
Myelodysplastic Syndrome|Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning
|
January 15, 2021 | Phase 2|Phase 3 |
| NCT00005641 | H. Lee Moffitt Cancer Center and Research Institute|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
September 1997 | Phase 2 |
| NCT02282904 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Chronic Granulomatous Disease
|
October 23, 2014 | Phase 1|Phase 2 |
| NCT00020566 | University of Leicester|National Cancer Institute (NCI)|Children´s Cancer and Leukaemia Group|Societe Francaise Oncologie Pediatrique|European Organisation for Research and Treatment of Cancer - EORTC|Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany|Gesellschaft fur Padiatrische Onkologie und Hamatologie - Austria|Swiss Group for Clinical Cancer Research|EBMT Solid Tumors Working Party|Children´s Oncology Group |
Sarcoma
|
February 2001 | Phase 3 |
| NCT03384225 | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine|Changhai Hospital|Xiangya Hospital of Central South University|Tongji Hospital|Wuhan Union Hospital, China|Chengdu PLA General Hospital|Tang-Du Hospital|Fujian Medical University Union Hospital |
High Risk Acute Myeloid Leukemia|Allogeneic Hematopoeitic Stem Cell Transplantation
|
August 1, 2016 | Phase 3 |
| NCT01666080 | Masonic Cancer Center, University of Minnesota |
Hematologic Disorders|Hemoglobinopathies|Immunodeficiencies
|
August 2012 | Not Applicable |
| NCT00112645 | Milton S. Hershey Medical Center|National Cancer Institute (NCI) |
Neuroblastoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
|
April 2005 | Phase 1 |
| NCT00499889 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Leukemia
|
February 2003 | Phase 2 |
| NCT01800643 | Hospital Israelita Albert Einstein |
Acute Leukemia|Chronic Leukemia|Lymphoproliferative Disease|Myeloproliferative Disease|Immunodeficiency
|
March 2010 | Phase 2|Phase 3 |
| NCT00006126 | Northwestern University|National Cancer Institute (NCI) |
Breast Cancer|Kidney Cancer|Lung Cancer|Melanoma (Skin)|Testicular Germ Cell Tumor
|
September 1999 | Phase 1 |
| NCT00536601 | Roswell Park Cancer Institute|National Cancer Institute (NCI) |
Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK+T-cell Lymphoma|Ewing Sarcoma+Peripheral Primitive Neuroectodermal Tumor (PNET)|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Peripheral T-cell Lymphoma|Plasma Cell Neoplasm|Primary Systemic Amyloidosis|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Ewing Sarcoma+Peripheral Primitive Neuroectodermal Tumor|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Malignant Testicular Germ Cell Tumor|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Neuroblastoma|Recurrent Small Lymphocytic Lymphoma|Recurrent+Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Multiple Myeloma|Regional Neuroblastoma|Splenic Marginal Zone Lymphoma|Testicular Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
|
June 29, 2006 | Not Applicable |
| NCT04872595 | Memorial Sloan Kettering Cancer Center |
Acute Myeloid Leukemia (AML)|Acute Lymphoid Leukemia (ALL)|Myelodysplastic Syndromes (MDS)
|
April 30, 2021 | Phase 2 |
| NCT00005986 | Masonic Cancer Center, University of Minnesota |
Leukemia
|
August 2000 | Phase 2 |
| NCT02660281 | University of Rochester |
Hematological Disease|Immune Deficiencies|Solid Tumors|Myelofibrosis|Multiple Myeloma|Lymphoma
|
October 2015 | Phase 1 |
| NCT01339910 | Medical College of Wisconsin|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI)|Blood and Marrow Transplant Clinical Trials Network|National Marrow Donor Program |
Leukemia, Myelocytic, Acute
|
June 2011 | Phase 3 |
| NCT00025649 | European Infant Neuroblastoma Study Group - 1999|National Cancer Institute (NCI) |
Neuroblastoma
|
July 1999 | Phase 2 |
| NCT00328029 | University Hospital, Strasbourg, France |
Signs and Symptoms, Respiratory
|
July 2006 | Phase 2 |
| NCT00002768 | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) |
Leukemia
|
June 1996 | Phase 2 |
| NCT03579875 | Masonic Cancer Center, University of Minnesota |
Fanconi Anemia|Severe Aplastic Anemia|Myelodysplastic Syndromes
|
November 13, 2018 | Phase 2 |
| NCT01119066 | Memorial Sloan Kettering Cancer Center |
Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Multiple Myeloma
|
May 3, 2010 | Phase 2 |
| NCT00469144 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Myelodysplastic Syndrome|Leukemia|Acute Myeloid Leukemia
|
June 2005 | Phase 3 |
| NCT01572662 | M.D. Anderson Cancer Center |
Leukemia|Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Chronic Myeloid Leukemia|Chronic Lymphocytic Leukemia|Myeloproliferative Diseases|Non-Hodgkins Lymphoma|Hodgkins Lymphoma|Multiple Myeloma|Myelodysplastic Syndrome
|
April 11, 2012 | Phase 2 |
| NCT00531310 | Columbia University |
Chronic Myeloid Leukemia
|
January 2003 | Phase 2 |
| NCT00003335 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
January 1998 | Phase 2 |
| NCT01852071 | University of California, Los Angeles|National Institute of Allergy and Infectious Diseases (NIAID)|National Human Genome Research Institute (NHGRI)|National Heart, Lung, and Blood Institute (NHLBI)|Orchard Therapeutics |
ADA-SCID
|
August 2, 2013 | Phase 1|Phase 2 |
| NCT00818961 | Northside Hospital, Inc.|Blood and Marrow Transplant Group of Georgia |
Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
May 2005 | Phase 2 |
| NCT02328950 | Fujian Medical University |
Myelodysplastic Syndromes|Leukemia, Myeloid, Acute|Precursor Cell Lymphoblastic Leukemia-Lymphoma
|
December 2014 | |
| NCT00553202 | Children´s Oncology Group|National Cancer Institute (NCI) |
Leukemia
|
January 2008 | Phase 2 |
| NCT04098653 | Nanfang Hospital of Southern Medical University|Peking University People´s Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University|Zhujiang Hospital |
Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning|Myeloid Tumors
|
September 2019 | Phase 2|Phase 3 |
| NCT01500161 | Texas Oncology Cancer Center |
Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Hodgkins Disease|Non-Hodgkins Lymphoma|Aplastic Anemia|Multiple Myeloma|Myelodysplastic Syndrome
|
November 2011 | Phase 2 |
| NCT01410344 | Medical College of Wisconsin|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI)|Blood and Marrow Transplant Clinical Trials Network|National Marrow Donor Program |
Leukemia|Lymphoma|HIV
|
September 2011 | Phase 2 |
| NCT00638898 | City of Hope Medical Center |
Solid Tumor|Adult Central Nervous System Germ Cell Tumor|Adult Rhabdomyosarcoma|Childhood Central Nervous System Germ Cell Tumor|Childhood Soft Tissue Sarcoma|Ewing Sarcoma|Metastatic Ewing Sarcoma+Peripheral Primitive Neuroectodermal Tumor|Ovarian Mixed Germ Cell Tumor|Previously Untreated Childhood Rhabdomyosarcoma|Recurrent Adult Brain Tumor|Recurrent Adult Soft Tissue Sarcoma|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Malignant Germ Cell Tumor|Recurrent Childhood Medulloblastoma|Recurrent Childhood Pineoblastoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway and Hypothalamic Glioma|Recurrent Childhood Visual Pathway Glioma|Recurrent Ewing Sarcoma+Peripheral Primitive Neuroectodermal Tumor|Recurrent Extragonadal Germ Cell Tumor|Recurrent Extragonadal Non-seminomatous Germ Cell Tumor|Recurrent Malignant Testicular Germ Cell Tumor|Recurrent Neuroblastoma|Recurrent Ovarian Germ Cell Tumor|Recurrent Wilms Tumor and Other Childhood Kidney Tumors|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
|
February 26, 2007 | Phase 1 |
| NCT02671708 | Nanfang Hospital of Southern Medical University|Third Affiliated Hospital, Sun Yat-Sen University|Peking University People´s Hospital|Zhujiang Hospital|Guangzhou First People´s Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
Autologous Hematopoietic Stem Cell Transplantation|Acute Myeloid Leukemia|Conditioning
|
January 2016 | Phase 2|Phase 3 |
| NCT05303727 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
Neuroblastoma
|
August 2022 | Phase 2 |
| NCT02248597 | Wake Forest University Health Sciences|National Cancer Institute (NCI) |
Graft Versus Host Disease|Hematopoietic+Lymphoid Cancer
|
February 25, 2015 | Phase 2 |
| NCT02512497 | Ohio State University Comprehensive Cancer Center|Celgene Corporation |
Cutaneous T-cell Lymphoma|T-Prolymphocytic Leukemia|T-Large Granulocytic Leukemia|T-Lymphoblastic Leukemia+Lymphoma|Peripheral T-Cell Lymphoma
|
December 8, 2017 | Phase 1 |
| NCT00840684 | Institut Paoli-Calmettes|National Cancer Institute (NCI) |
Leukemia
|
January 2009 | Phase 1|Phase 2 |
| NCT00176878 | Masonic Cancer Center, University of Minnesota |
Diamond-Blackfan Anemia|Kostmann´s Neutropenia|Shwachman-Diamond Syndrome
|
June 2000 | Phase 2|Phase 3 |
| NCT00003336 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
January 1998 | Phase 2 |
| NCT04942730 | St. Petersburg State Pavlov Medical University |
Leukemia, Acute Lymphoblastic|Myeloid Leukemia, Acute|Biphenotypic Acute Leukemia|Lymphoblastic Lymphoma|Myelodysplastic Syndromes|Myeloproliferative Neoplasm
|
January 21, 2021 | Phase 2 |
| NCT00005893 | Fairview University Medical Center|Office of Rare Diseases (ORD) |
Neutropenia|Sickle Cell Anemia|Thalassemia Major|Red-Cell Aplasia, Pure
|
June 2000 | Not Applicable |
| NCT02129582 | Case Comprehensive Cancer Center |
Acute Myeloid Leukemia|Hematologic Malignancies|Acute Lymphocytic Leukemia|Non Hodgkin Lymphoma|Hodgkin Lymphoma|Multiple Myeloma|Myelodysplastic Syndrome|Chronic Lymphocytic Leukemia|Chronic Myeloid Leukemia|Myelofibrosis|Myeloproliferative Syndrome
|
November 5, 2014 | Phase 1 |
| NCT02500849 | City of Hope Medical Center|Sangamo Therapeutics|California Institute for Regenerative Medicine (CIRM) |
HIV
|
March 10, 2016 | Phase 1 |
| NCT00006056 | Fairview University Medical Center|Office of Rare Diseases (ORD) |
Chediak-Higashi Syndrome|Graft Versus Host Disease|X-Linked Lymphoproliferative Syndrome|Familial Erythrophagocytic Lymphohistiocytosis|Hemophagocytic Lymphohistiocytosis|Virus-Associated Hemophagocytic Syndrome
|
March 2000 | Not Applicable |
| NCT00990249 | M.D. Anderson Cancer Center |
Leukemia|Lymphoma|Allogeneic Haematopoietic Stem Cell Transplantation|Acute Lymphoblastic Leukemia
|
October 2009 | Phase 2 |
| NCT00796562 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Otsuka Pharmaceutical Co., Ltd.|National Center for Research Resources (NCRR) |
MDS|Leukemias|Lymphomas
|
December 2008 | Phase 2 |
| NCT02727803 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia With Myelodysplasia-Related Changes|Acute Myeloid Leukemia With Variant MLL Translocations|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Chemotherapy-Related Leukemia|Chronic Myelomonocytic Leukemia|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|ISS Stage II Plasma Cell Myeloma|ISS Stage III Plasma Cell Myeloma|Myelodysplastic Syndrome|Myelodysplastic Syndrome With Excess Blasts|Myelodysplastic Syndrome With Gene Mutation|Myelodysplastic+Myeloproliferative Neoplasm|Previously Treated Myelodysplastic Syndrome|Recurrent Acute Myeloid Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Hodgkin Lymphoma|Recurrent Non-Hodgkin Lymphoma|Refractory Acute Lymphoblastic Leukemia|Refractory Adult Acute Lymphoblastic Leukemia|Secondary Acute Myeloid Leukemia|Therapy-Related Myelodysplastic Syndrome
|
May 19, 2016 | Phase 2 |
| NCT00156858 | Alberta Health services|AHS Cancer Control Alberta |
Hematologic Malignancy
|
January 1998 | Not Applicable |
| NCT01003054 | M.D. Anderson Cancer Center |
Chronic Myelogenous Leukemia
|
March 2005 | Phase 2 |
| NCT01652092 | Masonic Cancer Center, University of Minnesota |
SCID|Omenn´s Syndrome|Reticular Dysgenesis|Wiskott-Aldrich Syndrome|Bare Lymphocyte Syndrome|Common Variable Immunodeficiency|Chronic Granulomatous Disease|CD40 Ligand Deficiency|Hyper IgM Syndrome|X-linked Lymphoproliferative Disease|Hemophagocytic Lymphohistiocytosis|Griscelli Syndrome|Chediak-Higashi Syndrome|Langerhan´s Cell Histiocytosis
|
September 4, 2012 | Not Applicable |
| NCT00003116 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
May 1997 | Phase 2 |
| NCT00668564 | Masonic Cancer Center, University of Minnesota |
Hurler´s Syndrome|Maroteaux-Lamy Syndrome|Sly Syndrome|Alpha Mannosidosis|Fucosidosis|Aspartylglucosaminuria|Sphingolipidoses|Krabbe Disease|Wolman´s Disease|Niemann-Pick Disease Type B|Niemann-Pick Disease, Type C
|
March 2008 | Phase 2 |
| NCT00002792 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic+Myeloproliferative Diseases
|
June 1996 | Phase 2 |
| NCT01338675 | Seoul National University Hospital |
Chronic Granulomatous Disease
|
January 2011 | Phase 1|Phase 2 |
| NCT01203020 | West Virginia University |
Hodgkin´s Lymphoma|Non-Hodgkin´s Lymphoma
|
October 12, 2010 | Phase 2 |
| NCT00024050 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes
|
February 2001 | Phase 2 |
| NCT00004088 | City of Hope Medical Center|National Cancer Institute (NCI) |
Multiple Myeloma and Plasma Cell Neoplasm
|
April 13, 1999 | Phase 2 |
| NCT01949129 | St. Anna Kinderkrebsforschung|ALL SCTped Forum|European Society for Blood and Marrow Transplantation|ALL-BFM Study Group|Assistance Publique - Hôpitaux de Paris|Dutch Childhood Oncology Group|Swiss Pediatric Oncology Group|Australian & New Zealand Children´s Haematology+Oncology Group |
Acute Lymphoblastic Leukaemia
|
April 2013 | Phase 2|Phase 3 |
| NCT00804947 | Fundacion Para La Investigacion Hospital La Fe |
Multiple Myeloma
|
September 2005 | Phase 2 |
| NCT02836639 | Pusan National University Hospital |
Lymphoma, Non-Hodgkin
|
February 2016 | Phase 2 |
| NCT03983850 | National Cancer Institute (NCI)|National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) |
Graft Versus Host Disease|Hematologic Neoplasms
|
July 9, 2019 | Phase 1|Phase 2 |
| NCT00003662 | Roswell Park Cancer Institute|National Cancer Institute (NCI) |
Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Thymic Carcinoma
|
August 1998 | Phase 2 |
| NCT01746173 | Dana-Farber Cancer Institute|Massachusetts General Hospital|Beth Israel Deaconess Medical Center |
T-cell Non-Hodgkin Lymphoma
|
July 2013 | Phase 2 |
| NCT00295997 | University of California, San Francisco|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Kidney Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
May 2005 | Not Applicable |
| NCT01274195 | Seoul National University Hospital |
Hematopoietic Stem Cell Transplantation
|
January 2011 | Phase 2 |
| NCT05589896 | Ossium Health, Inc.|Center for International Blood and Marrow Transplant Research |
Acute Leukemia|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Acute Biphenotypic Leukemia|Acute Undifferentiated Leukemia
|
March 2023 | Phase 1|Phase 2 |
| NCT03615105 | Memorial Sloan Kettering Cancer Center |
Acute Lymphoid Leukemia (ALL)|Acute Myeloid Leukemia (AML)|Chronic Myeloid Leukemia (CML)|Hodgkin Lymphoma|Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia
|
July 25, 2018 | Phase 2 |
| NCT00305708 | University of California, San Francisco|National Cancer Institute (NCI) |
Congenital Amegakaryocytic Thrombocytopenia|Diamond-blackfan Anemia|Fanconi Anemia|Leukemia|Severe Congenital Neutropenia|Thrombocytopenia
|
August 2000 | Phase 1|Phase 2 |
| NCT02627573 | St. Petersburg State Pavlov Medical University |
Leukemia, Chronic Myeloid|Myelodysplastic Syndromes|Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
|
July 2015 | Phase 2 |
| NCT02114502 | M.D. Anderson Cancer Center |
Myeloma
|
September 2014 | Phase 2 |
| NCT02670252 | Nanfang Hospital of Southern Medical University|Guangzhou First People´s Hospital|Zhujiang Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Third Affiliated Hospital, Sun Yat-Sen University|The First Affiliated Hospital of Zhengzhou University|Xiangya Hospital of Central South University|The Seventh Affiliated Hospital of Sun Yat-sen University|The First Affiliated Hospital of Guangzhou Medical University|Guangdong Second Provincial General Hospital|The Affiliated Hospital of Qingdao University|First People´s Hospital of Chenzhou|Guangzhou Panyu Central Hospital |
Allogeneic Hematopoietic Stem Cell Transplantation|Busulfan|Total Body Irradiation|Acute Lymphocytic Leukemia
|
January 2016 | Phase 3 |
| NCT00987636 | University Hospital Muenster |
Ewing´s Sarcoma
|
October 1, 2009 | Phase 3 |
| NCT00282282 | Dana-Farber Cancer Institute|Brigham and Women´s Hospital |
Graft Versus Host Disease|GVHD
|
January 2006 | Phase 2 |
| NCT01498016 | Shanghai Jiao Tong University School of Medicine |
Acute Leukemia
|
November 2011 | Phase 2 |
| NCT01534143 | Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) |
Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
|
February 2012 | Phase 2 |
| NCT01071239 | Medical College of Wisconsin|Memorial Sloan Kettering Cancer Center |
Fanconi Anemia
|
April 2009 | Phase 2 |
| NCT01798004 | Children´s Oncology Group|National Cancer Institute (NCI) |
Disseminated Neuroblastoma|Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Regional Neuroblastoma|Stage 4S Neuroblastoma
|
April 8, 2013 | Not Applicable |
| NCT00006363 | National Cancer Institute (NCI) |
Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Erythroid Leukemia (M6)|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Childhood Acute Basophilic Leukemia|Childhood Acute Eosinophilic Leukemia|Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Childhood Myelodysplastic Syndromes|de Novo Myelodysplastic Syndromes|Untreated Adult Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
|
November 2000 | Phase 3 |
| NCT00005866 | Southwest Oncology Group|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes
|
February 2000 | Phase 3 |
| NCT00623935 | University of Michigan Rogel Cancer Center |
Acute Myelogenous Leukemia
|
March 2007 | Phase 2 |
| NCT03384212 | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine|Changhai Hospital|Xiangya Hospital of Central South University|Tongji Hospital|Wuhan Union Hospital, China|Chengdu PLA General Hospital|Tang-Du Hospital|Fujian Medical University Union Hospital |
High Risk Acute Myeloid Leukemia|Allogeneic Hematopoeitic Stem Cell Transplantation
|
August 1, 2016 | Phase 3 |
| NCT00627666 | Asan Medical Center|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
January 2003 | Phase 2 |
| NCT03018223 | H. Lee Moffitt Cancer Center and Research Institute |
Non-Hodgkin´s Lymphoma|Acute Leukemia in Remission|Chronic Myeloid Leukemia|Primary Myelofibrosis|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndromes|Hodgkin Lymphoma|Multiple Myeloma
|
January 31, 2017 | Phase 1 |
| NCT04002115 | Milton S. Hershey Medical Center |
Acute Myeloid Leukemia
|
June 3, 2020 | Phase 2 |
| NCT00134017 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
June 2004 | Phase 2 |
| NCT00410982 | M.D. Anderson Cancer Center |
Leukemia|Lymphoma|Myeloma
|
December 2006 | Phase 1 |
| NCT00578292 | Baylor College of Medicine |
Thalassemia
|
February 2004 | Not Applicable |
| NCT00060255 | Roswell Park Cancer Institute |
Breast Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Testicular Germ Cell Tumor|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
|
December 1991 | Phase 2 |
| NCT05463133 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Chronic Granulomatous Disease
|
July 8, 2022 | Phase 1|Phase 2 |
| NCT01338987 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
Myelodysplastic Syndrome|Acute Lymphocytic Leukemia|Acute Myelogenous Leukemia|Chronic Myelogenous Leukemia|Chronic Myelomonocytic Leukemia
|
April 19, 2011 | Phase 2 |
| NCT01177371 | Case Comprehensive Cancer Center |
Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With T(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With T(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With T(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Acute Promyelocytic Leukemia (M3)|Adult Erythroleukemia (M6a)|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Adult Pure Erythroid Leukemia (M6b)|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Burkitt Lymphoma|Childhood Acute Erythroleukemia (M6)|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myeloid Leukemia in Remission|Childhood Acute Myelomonocytic Leukemia (M4)|Childhood Acute Promyelocytic Leukemia (M3)|Childhood Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Chronic Phase Chronic Myelogenous Leukemia|Cutaneous B-cell Non-Hodgkin Lymphoma|De Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Peripheral T-Cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult Non-Hodgkin Lymphoma|Recurrent Adult T-cell Leukemia+Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Multiple Myeloma|Relapsing Chronic Myelogenous Leukemia|Secondary Myelodysplastic Syndromes|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Testicular Lymphoma|Waldenstrom Macroglobulinemia
|
March 1988 | Phase 2 |
| NCT01390402 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Leukemia|Chronic Myelogenous Leukemia
|
January 2012 | Phase 2 |
| NCT00301951 | University of California, San Francisco|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
September 2004 | Phase 1 |
| NCT01056614 | Fred Hutchinson Cancer Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) |
Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Blastic Phase Chronic Myelogenous Leukemia|Childhood Acute Myeloid Leukemia in Remission|Childhood Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Chronic Phase Chronic Myelogenous Leukemia|de Novo Myelodysplastic Syndromes|Hematopoietic+Lymphoid Cancer|Myelodysplastic+Myeloproliferative Neoplasm, Unclassifiable|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Relapsing Chronic Myelogenous Leukemia
|
September 2004 | Phase 2 |
| NCT04688021 | Yi Luo|First Affiliated Hospital of Zhejiang University |
Leukemia|Graft-versus-host-disease
|
December 3, 2020 | Phase 2 |
| NCT01625351 | St. Jude Children´s Research Hospital|CURE Childhood Cancer, Inc. |
Ewing Sarcoma|Gastrointestinal Tumor|Germ Cell Tumor|Hepatic Tumor|Lymphoma|Wilms Tumor|Rhabdoid Tumor|Clear Cell Carcinoma|Renal Cell Carcinoma|Melanoma|Neuroblastoma|Rhabdomyosarcoma|Non-rhabdomyosarcoma
|
August 20, 2012 | Phase 1 |
| NCT02670109 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran |
Triple-Negative Invasive Breast Carcinoma|Residual Tumor
|
February 1, 2018 | Phase 2 |
| NCT00006367 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders
|
May 2000 | Phase 2 |
| NCT00265889 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Lymphoma
|
February 2002 | Phase 2 |
| NCT00346359 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
March 2006 | Phase 2 |
| NCT04339777 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
Lymphoproliferative Disorders|Autoimmune Lymphoproliferative|Immune System Diseases|Common Variable Immunodeficiency|Primary T-cell Immunodeficiency Disorders
|
September 22, 2020 | Phase 2 |
| NCT01050855 | Children´s Hospital of Philadelphia |
Non Malignant Diseases|Immunodeficiencies|Hemoglobinopathies
|
January 2008 | Phase 2 |
| NCT00822393 | medac GmbH |
Acute Myeloid Leukemia|Myelodysplastic Syndrome
|
November 24, 2008 | Phase 3 |
| NCT01181271 | Massachusetts General Hospital|Dana-Farber Cancer Institute |
Diffuse, Large B-Cell, Lymphoma|Lymphoma, Low-Grade|T-Cell Lymphoma|Mantle-Cell Lymphoma|Hodgkin´s Lymphoma|Chronic Lymphocytic Leukemia|Lymphoma, Small Lymphocytic
|
August 2010 | Phase 2 |
| NCT00005824 | AIDS Malignancy Consortium|National Cancer Institute (NCI) |
Lymphoma
|
November 2000 | Phase 2 |
| NCT00245115 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) |
Leukemia
|
October 2005 | Phase 1 |
| NCT04221035 | Gustave Roussy, Cancer Campus, Grand Paris |
High-Risk Neuroblastoma
|
November 5, 2019 | Phase 3 |
| NCT04220008 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Recurrent Aggressive Non-Hodgkin Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Burkitt Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent High Grade B-Cell Lymphoma|Recurrent T-Cell Non-Hodgkin Lymphoma|Recurrent Transformed B-Cell Non-Hodgkin Lymphoma
|
June 1, 2023 | Phase 2 |
| NCT01704716 | St. Anna Kinderkrebsforschung |
Neuroblastoma
|
February 2002 | Phase 3 |
| NCT00544115 | City of Hope Medical Center|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases|Precancerous+Nonmalignant Condition
|
October 16, 2001 | Phase 2 |
| NCT05293509 | M.D. Anderson Cancer Center |
Stem Cell Transplantation
|
September 30, 2022 | Phase 2 |
| NCT03653247 | Sangamo Therapeutics |
Sickle Cell Disease
|
March 6, 2019 | Phase 1|Phase 2 |
| NCT02916979 | Dartmouth-Hitchcock Medical Center |
Leukemia, Lymphoid|Leukemia, Myeloid|Myelodysplastic Syndromes|Myelofibrosis|Lymphoma, Malignant|Multiple Myeloma|Waldenstrom Macroglobulinemia
|
September 6, 2016 | Phase 1 |
| NCT00317408 | European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma|National Cancer Institute (NCI) |
Lymphoma
|
April 2004 | Not Applicable |
| NCT00003081 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Sarcoma
|
March 1998 | Phase 1 |
| NCT00436761 | Milton S. Hershey Medical Center|National Cancer Institute (NCI) |
Unspecified Childhood Solid Tumor, Protocol Specific
|
May 2004 | Phase 1 |
| NCT00357565 | Masonic Cancer Center, University of Minnesota |
Leukemia|Myelodysplastic Syndromes|Childhood Acute Myeloid Leukemia in Remission|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Childhood Acute Lymphoblastic Leukemia in Remission|Previously Treated Myelodysplastic Syndrome|Secondary Myelodysplastic Syndrome|Refractory Anemia With Excess Blasts in Transformation|Refractory Anemia With Excess Blasts|Refractory Anemia|De Novo Myelodysplastic Syndrome|Childhood Myelodysplastic Syndrome
|
November 2005 | Phase 2 |
| NCT00002789 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Leukemia
|
May 1996 | Phase 3 |
| NCT00004899 | Northwestern University|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
October 1999 | Phase 2 |
| NCT02589145 | M.D. Anderson Cancer Center|Celgene Corporation |
Lymphoma
|
June 22, 2016 | Phase 1|Phase 2 |
| NCT01359254 | University of Chicago |
Hematological Disease
|
April 2010 | Phase 2 |
| NCT00238433 | OHSU Knight Cancer Institute|National Cancer Institute (NCI) |
Lymphoma
|
March 2005 | Phase 2 |
| NCT01861106 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
GATA2|Immunodeficiency|MDS
|
July 24, 2013 | Phase 2 |
| NCT02250937 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Acute Myeloid Leukemia|Myelodysplastic Syndrome
|
October 27, 2014 | Phase 2 |
| NCT04384692 | Fred Hutchinson Cancer Center |
Primary Myelofibrosis|Secondary Myelofibrosis
|
December 18, 2020 | Phase 2 |
| NCT00534469 | City of Hope Medical Center|National Cancer Institute (NCI) |
Leukemia
|
February 8, 2000 | Phase 2 |
| NCT00448201 | UNC Lineberger Comprehensive Cancer Center|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
January 7, 2011 | Phase 2 |
| NCT02750254 | Washington University School of Medicine |
Acute Myeloid Leukemia|Myelodysplastic Syndrome|Acute Lymphocytic Leukemia
|
June 27, 2016 | Phase 1 |
| NCT00006246 | Pediatric Brain Tumor Consortium|National Cancer Institute (NCI) |
Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Leukemia|Lymphoma|Metastatic Cancer|Retinoblastoma|Sarcoma
|
November 2000 | Phase 1 |
| NCT00004896 | Northwestern University|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
October 1999 | Phase 2 |
| NCT00445744 | Fred Hutchinson Cancer Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) |
Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Childhood Acute Myeloid Leukemia in Remission|Childhood Myelodysplastic Syndromes|de Novo Myelodysplastic Syndromes|Essential Thrombocythemia|Myelodysplastic Syndrome With Isolated Del(5q)|Polycythemia Vera|Previously Treated Myelodysplastic Syndromes|Primary Myelofibrosis|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Secondary Myelofibrosis|Untreated Adult Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
|
December 2006 | Not Applicable |
| NCT00423826 | Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Precancerous Condition|Secondary Myelofibrosis
|
January 2007 | |
| NCT05617625 | Baptist Health South Florida |
Myelodysplastic Syndromes|Graft Vs Host Disease|Graft-versus-host-disease
|
December 2022 | Phase 2 |
| NCT00238368 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) |
Lymphoma
|
February 2004 | Phase 2 |
| NCT03151876 | Sichuan University |
Lymphoma
|
June 12, 2017 | Phase 2 |
| NCT00775931 | Masonic Cancer Center, University of Minnesota |
Severe Osteopetrosis
|
August 2008 | Phase 2|Phase 3 |
| NCT00630565 | Masonic Cancer Center, University of Minnesota |
Leukemia
|
July 26, 2006 | Phase 2|Phase 3 |
| NCT02961816 | M.D. Anderson Cancer Center |
Lymphoma
|
June 2017 | Phase 2 |
| NCT02806375 | St. Petersburg State Pavlov Medical University |
Primary Myelofibrosis|Myeloproliferative Disorders
|
January 2016 | Phase 1|Phase 2 |
| NCT01471444 | M.D. Anderson Cancer Center|Sanofi |
Disorder Related to Bone Marrow Transplantation|Leukemia|Transplantation Infection
|
November 2, 2011 | Phase 3 |
| NCT00611351 | Lori Maness Harris, MD|National Cancer Institute (NCI)|University of Nebraska |
Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases|Secondary Myelofibrosis
|
June 2005 | Phase 2 |
| NCT01773395 | Dana-Farber Cancer Institute|Massachusetts General Hospital|Beth Israel Deaconess Medical Center |
Myelodysplastic Syndrome|Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia
|
January 8, 2013 | Phase 2 |
| NCT00417053 | Children´s Cancer and Leukaemia Group|National Cancer Institute (NCI) |
Neuroblastoma
|
Phase 3 | |
| NCT00004181 | Northwestern University|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Multiple Myeloma and Plasma Cell Neoplasm
|
October 1999 | Phase 2 |
| NCT00802113 | Columbia University |
Non-Hodgkin´s Lymphoma|Hodgkins Disease
|
June 2003 | Phase 1|Phase 2 |
| NCT03619551 | Michael Pulsipher, MD|Children´s Hospital Los Angeles |
SCID
|
October 22, 2018 | Phase 2 |
| NCT04690192 | Zou Dehui|Juventas Cell Therapy Ltd.|Institute of Hematology & Blood Diseases Hospital |
Large B-cell Lymphoma
|
January 1, 2021 | Phase 1|Phase 2 |
| NCT01749293 | University of Illinois at Chicago |
Hematologic Malignancies
|
August 30, 2012 | Phase 2 |
| NCT03247088 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
|
July 30, 2017 | Phase 1|Phase 2 |
| NCT01707004 | University of Wisconsin, Madison|National Cancer Institute (NCI) |
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
|
May 16, 2013 | Phase 2 |
| NCT04708054 | M.D. Anderson Cancer Center |
Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome
|
October 21, 2021 | Phase 2 |
| NCT03597594 | St. Jude Children´s Research Hospital |
Severe Combined Immunodeficiency
|
September 8, 2021 | Phase 1|Phase 2 |
| NCT02629120 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Chronic Granulomatous Disease Transplant
|
December 17, 2015 | Phase 1|Phase 2 |
| NCT00301834 | University of California, San Francisco|National Cancer Institute (NCI) |
Congenital Amegakaryocytic Thrombocytopenia|Diamond-blackfan Anemia|Leukemia|Myelodysplastic Syndromes|Severe Congenital Neutropenia
|
January 2005 | Phase 2 |
| NCT01969942 | University of Louisville |
Ewing Sarcoma
|
April 2013 | Phase 1 |
| NCT01366612 | Hackensack Meridian Health |
Myeloid Malignancies|Acute Myelogenous Leukemia|Chronic Myelogenous Leukemia|Myeloproliferative Disorders|Myelodysplastic Syndrome
|
June 16, 2010 | Phase 3 |
| NCT02861417 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Hematopoietic and Lymphoid Cell Neoplasm|High Risk Acute Myeloid Leukemia|High Risk Myelodysplastic Syndrome|Lymphoproliferative Disorder|Myelodysplastic Syndrome|Myelodysplastic+Myeloproliferative Neoplasm|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent High Risk Myelodysplastic Syndrome|Recurrent Hodgkin Lymphoma|Recurrent Myelodysplastic Syndrome|Recurrent Non-Hodgkin Lymphoma|Recurrent Plasma Cell Myeloma
|
August 5, 2016 | Phase 2 |
| NCT01505569 | Masonic Cancer Center, University of Minnesota |
Ewing´s Family Tumors|Renal Tumors|Hepatoblastoma|Rhabdomyosarcoma|Soft Tissue Sarcoma|Primary Malignant Brain Neoplasms|Retinoblastoma|Medulloblastoma|Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET)|Atypical Teratoid+Rhabdoid Tumor (AT+RT)|CNS Tumors|Germ Cell Tumors
|
October 20, 2011 | Not Applicable |
| NCT02469974 | Marina Kremyanskaya|Incyte Corporation|Icahn School of Medicine at Mount Sinai |
Myelofibrosis|MF
|
May 2015 | Not Applicable |
| NCT02670564 | Swiss Pediatric Oncology Group|ALL SCTped Forum |
Acute Lymphoblastic Leukemia
|
April 2013 | Phase 4 |
| NCT01824693 | Children´s Oncology Group|National Cancer Institute (NCI) |
Juvenile Myelomonocytic Leukemia
|
June 24, 2013 | Phase 2 |
| NCT00002554 | Fred Hutchinson Cancer Center |
Leukemia
|
November 1993 | Phase 2 |
| NCT04859946 | M.D. Anderson Cancer Center|Incyte Corporation |
Hematologic and Lymphocytic Disorder
|
January 11, 2022 | Phase 1 |
| NCT00003972 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Breast Cancer
|
July 1998 | Phase 3 |
| NCT04098393 | Memorial Sloan Kettering Cancer Center |
Hematologic Malignancies
|
September 18, 2019 | Phase 1 |
| NCT00004907 | Northwestern University|National Cancer Institute (NCI) |
Lymphoma
|
October 1999 | Phase 1|Phase 2 |
| NCT00092937 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Granulomatous Disease|Chronic
|
September 23, 2004 | Phase 1 |
| NCT00084695 | Milton S. Hershey Medical Center|National Cancer Institute (NCI) |
Childhood Langerhans Cell Histiocytosis|Fanconi Anemia|Leukemia|Lymphoma|Myelodysplastic Syndromes|Neuroblastoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific
|
September 2003 | Phase 2 |
| NCT00002761 | Columbia University |
Leukemia
|
February 1996 | Phase 1|Phase 2 |
| NCT00005940 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
|
October 1999 | Phase 2 |
| NCT02083250 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Allogeneic Hematopoietic Stem Cell Transplantation Recipient|Myelodysplastic Syndrome|Previously Treated Myelodysplastic Syndrome|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia
|
March 6, 2014 | Phase 1 |
| NCT01018446 | Seoul National University Hospital |
Hematopoietic Stem Cell Transplantation
|
December 2008 | Phase 1 |
| NCT04982354 | Baptist Health South Florida|Jazz Pharmaceuticals |
Acute Myeloid Leukemia
|
July 5, 2022 | Phase 1|Phase 2 |
| NCT03613532 | Jacqueline Garcia, MD|National Institutes of Health (NIH)|Dana-Farber Cancer Institute |
Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)|Chronic Myelomonocytic Leukemia (CMML)|MDS+Myeloproliferative Neoplasm-unclassifiable (MDS+MPN-unclassifiable)|Hematopoietic Stem Cell Transplant
|
October 24, 2018 | Phase 1 |
| NCT04151706 | Stanford University|National Institutes of Health (NIH)|National Cancer Institute (NCI) |
Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndromes|Acute Leukemia|Chronic Myeloid Leukemia
|
February 27, 2020 | Phase 2 |
| NCT00054327 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
November 2000 | Phase 2 |
| NCT03794167 | Soonchunhyang University Hospital |
Non-hodgkin Lymphoma
|
June 1, 2012 | Phase 2 |
| NCT01622556 | University of Virginia |
Hematologic Malignancies
|
January 2012 | Phase 2 |
| NCT00002547 | Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes
|
August 1987 | Phase 2 |
| NCT02294552 | Ivan S Moiseev|St. Petersburg State Pavlov Medical University |
Acute Myeloid Leukemia|Acute Lymphoid Leukemia|Lymphoma|Myelodysplastic Syndromes|Chronic Lymphocytic Leukemia|Immune System Diseases
|
October 2014 | Phase 2 |
| NCT00003960 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) |
Leukemia|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
April 1998 | Phase 2 |
| NCT00253552 | OHSU Knight Cancer Institute|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases|Sarcoma
|
May 2004 | Not Applicable |
| NCT01758328 | Memorial Sloan Kettering Cancer Center |
Multiple Myeloma
|
December 2012 | Phase 1 |
| NCT01455506 | Hackensack Meridian Health |
Acute Myeloid Leukemia|Myelodysplastic Syndrome
|
May 2009 | Phase 1 |
| NCT03126916 | Children´s Oncology Group|National Cancer Institute (NCI) |
Ganglioneuroblastoma|Neuroblastoma
|
May 9, 2018 | Phase 3 |
| NCT01349101 | Sidney Kimmel Cancer Center at Thomas Jefferson University|Thomas Jefferson University |
Hematological Malignancies
|
February 10, 2011 | Phase 2 |
| NCT03530085 | Nanfang Hospital of Southern Medical University|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Guangzhou First People´s Hospital|Peking University People´s Hospital|Third Affiliated Hospital, Sun Yat-Sen University|Zhujiang Hospital |
Acute Myeloid Leukemia|Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning|Elderly
|
June 15, 2018 | Phase 2|Phase 3 |
| NCT00498316 | M.D. Anderson Cancer Center|ViaCell|National Institutes of Health (NIH)|National Cancer Institute (NCI) |
Myelodysplastic Syndrome|Leukemia
|
July 3, 2007 | Phase 1 |
| NCT00670410 | Columbia University |
Neuroblastoma
|
November 2003 | Phase 1 |
| NCT00402558 | M.D. Anderson Cancer Center |
Myelodysplastic Syndrome|Leukemia
|
May 2006 | Phase 1 |
| NCT03259503 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Recurrent Diffuse Large B-Cell Lymphoma|Recurrent T-Cell Non-Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma|Refractory Hodgkin Lymphoma|Refractory T-Cell Non-Hodgkin Lymphoma
|
September 13, 2019 | Phase 1 |
| NCT04370795 | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
Severe Combined Immune Deficiency (SCID)
|
November 28, 2022 | Phase 1|Phase 2 |
| NCT02793544 | Center for International Blood and Marrow Transplant Research|National Marrow Donor Program |
Myelodysplastic Syndrome (MDS)|Chronic Lymphocytic Leukemia (CLL)|Chemotherapy-sensitive Lymphoma|Acute Lymphoblastic Leukemia (ALL)+T Lymphoblastic Lymphoma|Acute Myelogenous Leukemia (AML)|Acute Biphenotypic Leukemia (ABL)|Acute Undifferentiated Leukemia (AUL)
|
December 2016 | Phase 2 |
| NCT00030719 | University of Leicester|National Cancer Institute (NCI) |
Neuroblastoma
|
December 2001 | Phase 3 |
| NCT00002798 | National Cancer Institute (NCI) |
Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Childhood Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Refractory Anemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Refractory Anemia With Ringed Sideroblasts|Secondary Myelodysplastic Syndromes|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
|
August 1996 | Phase 3 |
| NCT00002771 | German CML Study Group|National Cancer Institute (NCI) |
Leukemia
|
January 1995 | Phase 3 |
| NCT00258427 | Masonic Cancer Center, University of Minnesota |
Fanconi Anemia
|
March 26, 2002 | Phase 2 |
| NCT02047578 | Seoul National University Hospital |
Acute Lymphoblastic Leukemia
|
February 5, 2014 | Phase 2 |
| NCT03765632 | Great Ormond Street Hospital for Children NHS Foundation Trust|Orchard Therapeutics |
Severe Combined Immunodeficiency Due to ADA Deficiency
|
January 3, 2018 | Phase 1|Phase 2 |
| NCT05565105 | Baptist Health South Florida |
Leukemia, Myeloid, Acute|Leukemia, Lymphocytic, Acute
|
October 2022 | Phase 2 |
| NCT00113919 | University of Arkansas |
Multiple Myeloma
|
June 2004 | Phase 1|Phase 2 |
| NCT03795597 | Loyola University|Amgen |
Multiple Myeloma
|
May 22, 2019 | Phase 1|Phase 2 |
| NCT04547049 | First Affiliated Hospital of Zhejiang University |
Leukemia
|
September 1, 2020 | Phase 3 |
| NCT00077116 | European Organisation for Research and Treatment of Cancer - EORTC |
Leukemia|Myelodysplastic Syndromes
|
November 2003 | Phase 2 |
| NCT00004171 | Northwestern University|National Cancer Institute (NCI) |
Lymphoma
|
October 1999 | Phase 2 |
| NCT04904588 | Center for International Blood and Marrow Transplant Research|National Marrow Donor Program |
Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Mixed Phenotype Acute Leukemia|Acute Leukemia|Myelodysplastic Syndromes|Chronic Myelogenous Leukemia|Chronic Lymphocytic Leukemia|Lymphoma
|
September 30, 2021 | Phase 2 |
| NCT01427881 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Myeloid Leukemia in Remission|Adult Erythroleukemia (M6a)|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Adult Pure Erythroid Leukemia (M6b)|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Acute Erythroleukemia (M6)|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Myeloid Leukemia in Remission|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Myelodysplastic Syndromes|Childhood Nasal Type Extranodal NK+T-cell Lymphoma|Chronic Myelomonocytic Leukemia|Chronic Phase Chronic Myelogenous Leukemia|Cutaneous B-cell Non-Hodgkin Lymphoma|de Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Philadelphia Chromosome Negative Chronic Myelogenous Leukemia|Post-transplant Lymphoproliferative Disorder|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia+Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent+Refractory Childhood Hodgkin Lymphoma|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage III Multiple Myeloma|Testicular Lymphoma|Waldenström Macroglobulinemia
|
September 2011 | Phase 2 |
| NCT00070174 | Children´s Oncology Group|National Cancer Institute (NCI) |
Leukemia
|
December 2003 | Phase 2 |
| NCT00478244 | Masonic Cancer Center, University of Minnesota |
Epidermolysis Bullosa
|
April 2007 | Not Applicable |
| NCT01175356 | Children´s Oncology Group|National Cancer Institute (NCI) |
Disseminated Neuroblastoma|Ganglioneuroblastoma|Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Regional Neuroblastoma|Stage 4S Neuroblastoma
|
October 2010 | Not Applicable |
| NCT00025402 | III. Medizinische Klinik Mannheim|National Cancer Institute (NCI) |
Leukemia
|
July 1997 | Phase 3 |
| NCT03096782 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Biphenotypic Leukemia|Acute Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Chemotherapy-Related Leukemia|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Myelomonocytic Leukemia|Hodgkin Lymphoma|Langerhans Cell Histiocytosis|Minimal Residual Disease|Myelodysplastic Syndrome|Myelodysplastic Syndrome With Excess Blasts|Non-Hodgkin Lymphoma|Recurrent Hodgkin Lymphoma|Refractory Acute Lymphoblastic Leukemia|Refractory Myelodysplastic Syndrome|Small Lymphocytic Lymphoma|Therapy-Related Myelodysplastic Syndrome
|
October 13, 2017 | Phase 2 |
| NCT03779854 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Acute Biphenotypic Leukemia|Acute Leukemia|Acute Leukemia of Ambiguous Lineage|Acute Lymphoblastic Leukemia|Acute Undifferentiated Leukemia|Allogeneic Hematopoietic Stem Cell Transplantation Recipient|Blastic Plasmacytoid Dendritic Cell Neoplasm|Blasts Under 25 Percent of Bone Marrow Nucleated Cells|Blasts Under 5 Percent of Bone Marrow Nucleated Cells|Mixed Phenotype Acute Leukemia|Myelodysplastic Syndrome With Excess Blasts-1|Myelodysplastic Syndrome With Excess Blasts-2
|
August 29, 2019 | Phase 2 |
| NCT04644016 | Memorial Sloan Kettering Cancer Center |
AML|ALL|MDS|MPD Withou Myelofibrosis|NHL or HL|Inherited Metabolic Disorders|Hemoglobinopathies|Bone Marrow Failure|HLH
|
November 20, 2020 | Phase 2 |
| NCT03016806 | University of Rochester |
Acute Leukemia|Immune Deficiency Disorder|Congenital Hematological Disorder|Metabolism Disorder|Aplastic Anemia|Myelodysplastic Syndromes|Chronic Leukemia|Lymphoma|Multiple Myeloma|Solid Tumor
|
June 2015 | Phase 1 |
| NCT01093586 | Case Comprehensive Cancer Center |
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Erythroleukemia (M6a)|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Adult Pure Erythroid Leukemia (M6b)|B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|Blastic Phase Chronic Myelogenous Leukemia|Burkitt Lymphoma|Childhood Acute Erythroleukemia (M6)|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloid Leukemia in Remission|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Myelodysplastic Syndromes|Childhood Nasal Type Extranodal NK+T-cell Lymphoma|Chronic Myelomonocytic Leukemia|Chronic Phase Chronic Myelogenous Leukemia|Cutaneous B-cell Non-Hodgkin Lymphoma|de Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Juvenile Myelomonocytic Leukemia|Myelodysplastic+Myeloproliferative Neoplasm, Unclassifiable|Nodal Marginal Zone B-cell Lymphoma|Previously Treated Myelodysplastic Syndromes|Prolymphocytic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Relapsing Chronic Myelogenous Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Secondary Myelofibrosis|Splenic Marginal Zone Lymphoma|Stage I Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia|T-cell Adult Acute Lymphoblastic Leukemia|T-cell Childhood Acute Lymphoblastic Leukemia|T-cell Large Granular Lymphocyte Leukemia|Waldenstrom Macroglobulinemia
|
September 2007 | Phase 2 |
| NCT02007863 | University of Miami |
Leukemia|Myelodysplasia|Acute Lymphocytic Leukemia|Acute Myelogenous Leukemia
|
August 2008 | Not Applicable |
| NCT00003195 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Multiple Myeloma and Plasma Cell Neoplasm
|
December 1997 | Phase 2 |
| NCT00795132 | University of Utah |
Acute Leukaemia|Chronic Disease|Leukemia|Myelodysplasia|Lymphoma
|
April 2004 | Phase 2 |
| NCT00245037 | OHSU Knight Cancer Institute|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms|Precancerous Condition
|
June 2005 | Phase 1|Phase 2 |
| NCT02744742 | Nanfang Hospital of Southern Medical University|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Institute of Hematology and Blood Diseases Hospital|Peking University People´s Hospital|First People´s Hospital of Chenzhou|Liuzhou Workers Hospital |
Myelodysplastic Syndrome|Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning
|
April 18, 2016 | Phase 2|Phase 3 |
| NCT04451200 | Institut Paoli-Calmettes |
Acute Leukemia|Mielodysplasic Syndrome|Myeloproliferative Neoplasm
|
November 2020 | Phase 2 |
| NCT01048827 | University of California, San Francisco |
Acute Myeloid Leukemia
|
November 2009 | Phase 1 |
| NCT00361140 | H. Lee Moffitt Cancer Center and Research Institute |
Myelodysplastic Syndromes|Myeloproliferative Disorders|Leukemia, Lymphocytic|Myeloma|Lymphoma
|
August 2005 | Phase 4 |
| NCT01043640 | Masonic Cancer Center, University of Minnesota |
Mucopolysaccharidosis|Hurler Syndrome|Hunter Syndrome|Maroteaux-Lamy Syndrome|Sly Syndrome|Alpha Mannosidosis|Fucosidosis|Aspartylglucosaminuria|Adrenoleukodystrophy (ALD)|Krabbe Disease|Metachromatic Leukodystrophy (MLD)|Sphingolipidoses|Peroxisomal Disorders
|
December 2009 | Phase 2 |
| NCT01596699 | University of California, San Francisco |
Myeloid Malignancy|Bone Marrow Failure Syndrome|Transfusion-dependent Red Blood Cell (RBC) Defect|Congenital Immunodeficiency|Metabolic Disease|Severe Immune Dysregulation
|
May 24, 2012 | Phase 2 |
| NCT00619645 | University of California, Davis |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
June 2007 | Phase 2 |
| NCT02582775 | Masonic Cancer Center, University of Minnesota |
Epidermolysis Bullosa
|
March 2016 | Phase 2 |
| NCT00281983 | German CLL Study Group |
Chronic Lymphocytic Leukemia
|
June 2000 | Phase 1|Phase 2 |
| NCT05579769 | St. Jude Children´s Research Hospital |
Hematologic Malignancy|Myeloid Malignancy
|
November 4, 2022 | Phase 2 |
| NCT00555048 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
September 2007 | Phase 1|Phase 2 |
| NCT04776850 | M.D. Anderson Cancer Center |
Beta Thalassemia Major|Sickle Beta 0 Thalassemia|Sickle Beta Plus Thalassemia|Sickle Beta Thalassemia|Sickle Cell Disease|Sickle Cell-SS Disease
|
December 29, 2020 | Early Phase 1 |
| NCT01621477 | St. Jude Children´s Research Hospital|Assisi Foundation |
Acute Lymphoblastic Leukemia|Acute Myelocytic Leukemia|Chronic Myelocytic Leukemia|Juvenile Myelomonocytic Leukemia|Myelodysplastic Syndrome|Hodgkin or Non-Hodgkin Lymphoma|Sarcoma, Myeloid
|
August 2012 | Phase 2 |
| NCT01786018 | Azienda Ospedaliera San Giovanni Battista |
B-cell Lymphoma Refractory
|
February 2013 | Phase 2 |
| NCT02251821 | Fred Hutchinson Cancer Center|Incyte Corporation|National Cancer Institute (NCI) |
Primary Myelofibrosis|Secondary Myelofibrosis
|
October 20, 2014 | Phase 2 |
| NCT05598593 | First Affiliated Hospital of Zhejiang University |
Cytarabine&addition;Thiotepa &addition; Fludarabine &addition; Busulfan|T Cell Acute Lymphoblastic Leukemia+Lymphoblastic Lymphoma
|
October 23, 2022 | Phase 2 |
| NCT02605460 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran |
Acute Myeloid Leukemia|Acute Lymphoid Leukemia
|
February 2014 | Phase 2 |
| NCT03517631 | Shanghai Public Health Clinical Center|R&D Kanglin Biotech |
HIV Infections|AIDS
|
February 27, 2018 | Phase 1 |
| NCT01200329 | M.D. Anderson Cancer Center |
Lymphoma
|
June 2011 | Phase 2 |
| NCT01512888 | St. Jude Children´s Research Hospital|National Heart, Lung, and Blood Institute (NHLBI)|Assisi Foundation|California Institute for Regenerative Medicine (CIRM) |
Severe Combined Immunodeficiency Disease, X-linked
|
August 17, 2016 | Phase 1|Phase 2 |
| NCT00002961 | Children´s Hospital of Philadelphia |
Leukemia
|
October 1995 | Phase 3 |
| NCT03315078 | National Institute of Allergy and Infectious Diseases (NIAID) |
X-Linked Combined Immunodeficiency Diseases
|
April 2012 | Phase 1|Phase 2 |
| NCT00003414 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) |
Graft Versus Host Disease|Lymphoma
|
October 1997 | Phase 3 |
| NCT05327023 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
Hematologic Neoplasms
|
May 23, 2022 | Phase 1|Phase 2 |
| NCT00502905 | M.D. Anderson Cancer Center |
Leukemia
|
October 2003 | Phase 2 |
| NCT00857389 | M.D. Anderson Cancer Center |
Stem Cell Transplantation|Leukemia|Lymphoma
|
March 2, 2009 | Phase 2 |
| NCT00874315 | Nationwide Children´s Hospital |
Neuroblastoma
|
September 2008 | Phase 2 |
| NCT03602898 | Fred Hutchinson Cancer Center |
Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Chronic Myelomonocytic Leukemia|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Hematopoietic and Lymphoid System Neoplasm|Myelodysplastic Syndrome|Myelofibrosis|Myeloproliferative Neoplasm|Recurrent Acute Myeloid Leukemia|Recurrent Hodgkin Lymphoma|Recurrent Non-Hodgkin Lymphoma|Refractory Acute Myeloid Leukemia|Therapy-Related Acute Myeloid Leukemia
|
June 1, 2021 | Phase 2 |
| NCT01247701 | Baylor College of Medicine|Center for Cell and Gene Therapy, Baylor College of Medicine |
Myeloid Hematological Malignancies
|
November 2010 | Not Applicable |
| NCT02799147 | St. Petersburg State Pavlov Medical University |
Leukemia, Acute Lymphoblastic|Acute Myeloid Leukemia|Mixed-Lineage Acute Leukemias
|
June 2016 | Phase 1|Phase 2 |
| NCT00408447 | Columbia University |
Sickle Cell Disease|Beta Thalassemia
|
September 2004 | Phase 2 |
| NCT00281879 | OHSU Knight Cancer Institute|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms|Unusual Cancers of Childhood
|
February 2006 | Phase 2 |
| NCT00003913 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) |
Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
December 1998 | Phase 2 |
| NCT00003270 | Roswell Park Cancer Institute |
Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
September 4, 1997 | Phase 2 |
| NCT00813124 | M.D. Anderson Cancer Center|National Cancer Institute (NCI)|Celgene Corporation |
Stem Cell Transplantation|Leukemia
|
December 2008 | Phase 2 |
| NCT00454480 | The University of New South Wales|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes
|
August 2006 | Phase 2|Phase 3 |
| NCT00054340 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
October 2002 | Phase 1|Phase 2 |
| NCT03121014 | University of Illinois at Chicago |
Acute Myeloid Leukemia|Myelodysplastic Syndromes
|
April 24, 2017 | Phase 2 |
| NCT02120157 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
Myeloablative Conditioning|HLA-mismatched Bone Marrow Transplantation|Graft Survival|Transplantation, Bone Marrow
|
July 2, 2015 | Phase 2 |
| NCT00049517 | Eastern Cooperative Oncology Group|National Cancer Institute (NCI) |
Leukemia
|
December 2002 | Phase 3 |
| NCT00003661 | Roswell Park Cancer Institute |
Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Neuroblastoma
|
June 1998 | Phase 2 |
| NCT03602131 | Sichuan University |
Hodgkin Lymphoma|Non-hodgkin Lymphoma
|
January 1, 2019 | Phase 2 |
| NCT00027924 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Leukemia|Myelodysplastic Syndromes
|
October 2001 | Phase 2 |
| NCT00815568 | Samsung Medical Center |
AML|MDS|ALL|CML|Lymphoma
|
August 2008 | Phase 2 |
| NCT00003060 | Louisiana State University Health Sciences Center Shreveport |
Melanoma (Skin)
|
March 1995 | Phase 1 |
| NCT00179764 | Ann & Robert H Lurie Children´s Hospital of Chicago |
Tumors|Malignant Melanoma|Hematological Malignancies|Myelogenous Leukemia, Chronic|Leukemia, Lymphoblastic, Acute
|
March 10, 2000 | Not Applicable |
| NCT00153985 | Dana-Farber Cancer Institute|Beth Israel Deaconess Medical Center|Massachusetts General Hospital|Brigham and Women´s Hospital|Emory University|Feist-Weiller Cancer Center at Louisiana State University Health Sciences|Ohio State University |
Hemoglobinopathies|Sickle Cell Disease|Thalassemia
|
March 2004 | Phase 2 |
| NCT01795430 | City of Hope Medical Center|National Cancer Institute (NCI) |
Adult Supratentorial Primitive Neuroectodermal Tumor (PNET)|Ewing Sarcoma of Bone|Extraosseous Ewing Sarcoma|Metastatic Ewing Sarcoma+Peripheral Primitive Neuroectodermal Tumor|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Ewing Sarcoma+Peripheral Primitive Neuroectodermal Tumor|Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor
|
July 2013 | Not Applicable |
| NCT00055653 | Roswell Park Cancer Institute|National Heart, Lung, and Blood Institute (NHLBI) |
Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic-Myeloproliferative Diseases
|
January 2003 | Phase 2 |
| NCT00550992 | Dutch Childhood Oncology Group|BFM Germany|CORS Monza Italy|Associazione Italiana Ematologia Oncologia Pediatrica|Australian and New Zealand Children´s Oncology Group|BFM Austria|CLCG France Belgium Portugal|COALL Germany|CPH, Czech republic|DFCI consortium USA|FRALLE France|Hong Kong|MD Anderson USA|NOPHO Scandinavian countries|PINDA, Chile|PPLLSG Poland|Seattle USA|SJCRH USA|UKCCSG United Kingdom |
Leukemia
|
January 2006 | Not Applicable |
| NCT00521430 | Asan Medical Center|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Nonmalignant Neoplasm|Unspecified Adult Solid Tumor, Protocol Specific
|
April 2004 | Not Applicable |
| NCT00740467 | Institut Paoli-Calmettes|National Cancer Institute (NCI) |
Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Precancerous Condition
|
January 2008 | Phase 2 |
| NCT00304018 | University of California, San Francisco|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
October 2002 | Phase 1 |
| NCT00003816 | Roswell Park Cancer Institute |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases|Nonmalignant Neoplasm|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
|
October 19, 1998 | Phase 2|Phase 3 |
| NCT03792815 | Soonchunhyang University Hospital |
Non-Hodgkin´s Lymphoma
|
October 2009 | Phase 2 |
| NCT05457556 | Children´s Oncology Group |
Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome
|
November 23, 2022 | Phase 3 |
| NCT04127721 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Allogeneic Stem Cell Transplant Recipient|Hematologic and Lymphocytic Disorder|Hematopoietic and Lymphoid Cell Neoplasm
|
September 22, 2020 | Phase 2 |
| NCT01384513 | Sidney Kimmel Cancer Center at Thomas Jefferson University|Thomas Jefferson University |
Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Aplastic Anemia|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Myelodysplastic Syndromes|Chronic Eosinophilic Leukemia|Chronic Myelomonocytic Leukemia|Chronic Neutrophilic Leukemia|Essential Thrombocythemia|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Juvenile Myelomonocytic Leukemia|Mastocytosis|Myelodysplastic+Myeloproliferative Neoplasm, Unclassifiable|Nodal Marginal Zone B-cell Lymphoma|Polycythemia Vera|Previously Treated Myelodysplastic Syndromes|Primary Myelofibrosis|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent+Refractory Childhood Hodgkin Lymphoma|Refractory Anemia|Refractory Anemia With Ringed Sideroblasts|Refractory Hairy Cell Leukemia|Refractory Multiple Myeloma|Secondary Myelodysplastic Syndromes|Splenic Marginal Zone Lymphoma|T-cell Large Granular Lymphocyte Leukemia|Waldenström Macroglobulinemia
|
August 4, 2011 | Phase 2 |
| NCT02506959 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Plasma Cell Leukemia|Plasmacytoma|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
|
September 14, 2015 | Phase 2 |
| NCT02349906 | medac GmbH|Celerion|Venn Life Sciences|Syneos Health |
Primary Immunodeficiencies|Inborn Errors of Metabolism|Haemoglobinopathies|Bone Marrow Failure Syndromes
|
April 2015 | Phase 2 |
| NCT01168219 | National Cancer Institute (NCI) |
Acute Myeloid Leukemia|Adult Acute Megakaryoblastic Leukemia|Adult Acute Monoblastic Leukemia|Adult Acute Monocytic Leukemia|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With Maturation|Adult Acute Myeloid Leukemia With Minimal Differentiation|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-MLL|Adult Acute Myeloid Leukemia Without Maturation|Adult Acute Myelomonocytic Leukemia|Adult Erythroleukemia|Adult Pure Erythroid Leukemia|Alkylating Agent-Related Acute Myeloid Leukemia|de Novo Myelodysplastic Syndrome|Myelodysplastic Syndrome|Myelodysplastic Syndrome With Excess Blasts|Recurrent Adult Acute Myeloid Leukemia|Secondary Myelodysplastic Syndrome
|
July 15, 2010 | Phase 2 |
| NCT01176006 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) |
DOCK8 Deficiency
|
October 5, 2010 | Phase 2 |
| NCT01701986 | M.D. Anderson Cancer Center|National Cancer Institute (NCI) |
Hematopoietic Cell Transplantation Recipient|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Hodgkin Lymphoma|Refractory T-Cell Non-Hodgkin Lymphoma
|
October 25, 2012 | Phase 1|Phase 2 |
| NCT00863148 | Nantes University Hospital |
MDS|AML|ALL|BAL
|
October 2009 | Phase 2 |
| NCT01135329 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
Lymphoma|Leukemia|Myelodysplastic Syndrome
|
August 2010 | Phase 2 |
| NCT00002868 | Eastern Cooperative Oncology Group|National Cancer Institute (NCI) |
Leukemia
|
January 1996 | Phase 3 |
| NCT00705120 | St. Jude Children´s Research Hospital |
Osteogenesis Imperfecta
|
November 1995 | Phase 1 |
| NCT04282174 | Baptist Health South Florida |
Hematologic Diseases|Hematologic Malignancy|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Chronic Myelogenous Leukemia|Chronic Lymphocytic Leukemia
|
September 2022 | Phase 2 |
| NCT03515707 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Acute Myeloid Leukemia|Minimal Residual Disease Negativity
|
July 10, 2018 | Phase 2 |
| NCT00040469 | Baylor College of Medicine|The Methodist Hospital Research Institute|Center for Cell and Gene Therapy, Baylor College of Medicine |
Sickle Cell Anemia|Hemoglobinopathy|Thalassemia
|
August 2000 | Phase 2 |
| NCT04786002 | The First Affiliated Hospital of Soochow University|Children´s Hospital Of Soochow University|Children´s Hospital of Fudan University|Fujian Medical University Union Hospital|Guangzhou Women and Children´s Medical Center|West China Second University Hospital|Beijing Children´s Hospital|Shenzhen Children´s Hospital|The First Affiliated Hospital of Zhengzhou University |
Hematopoietic Stem Cell Transplantation
|
November 1, 2020 | |
| NCT00836628 | Ann & Robert H Lurie Children´s Hospital of Chicago |
Refractory Brain Tumors
|
July 2008 | Phase 1 |
| NCT00623077 | Masonic Cancer Center, University of Minnesota |
Brain and Central Nervous System Tumors|Kidney Cancer|Liver Cancer|Retinoblastoma|Sarcoma
|
August 2005 | Phase 1 |
| NCT00301912 | University of California, San Francisco|National Cancer Institute (NCI) |
Anemia|Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Diseases
|
January 2002 | Phase 2 |
| NCT00806767 | Institut Paoli-Calmettes|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
March 2007 | Phase 2 |
| NCT01118013 | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) |
Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms
|
December 2010 | Phase 2 |
| NCT00003875 | Fred Hutchinson Cancer Center|National Cancer Institute (NCI) |
Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Childhood Acute Myeloid Leukemia in Remission|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia
|
October 13, 1998 | Phase 2 |
| NCT00667927 | St. Jude Children´s Research Hospital |
Acute Myeloid Leukemia
|
March 1991 | Phase 1 |
| NCT00002592 | Abramson Cancer Center of the University of Pennsylvania|National Cancer Institute (NCI) |
Leukemia
|
June 1993 | Phase 2 |
| NCT00852163 | Baylor Research Institute|Genzyme, a Sanofi Company |
Leukemia|Myelodysplastic Syndrome
|
March 2007 | Phase 2 |
| NCT01380990 | Great Ormond Street Hospital for Children NHS Foundation Trust|Orchard Therapeutics |
Adenosine Deaminase Deficiency|Severe Combined Immunodeficiencies (SCID)
|
November 15, 2012 | Phase 1|Phase 2 |
| NCT00296023 | University of California, San Francisco|National Cancer Institute (NCI) |
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
|
January 1999 | Not Applicable |
| NCT00427765 | M.D. Anderson Cancer Center |
Multiple Myeloma|Lymphoma
|
December 2004 | Phase 2 |
| NCT02544425 | Samsung Medical Center |
Extranodal NK-T-Cell Lymphoma
|
February 21, 2016 | Phase 2 |
| NCT02784561 | Chinese PLA General Hospital|309th Hospital of Chinese People´s Liberation Army|Beijing Naval General Hospital|Space Center Hospital, Peking University |
Leukemia
|
July 2016 | Phase 4 |
| NCT00070135 | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) |
Adult Acute Myeloid Leukemia in Remission|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
|
January 2004 | Phase 2 |
| NCT01959477 | Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
Adult Grade III Lymphomatoid Granulomatosis|Adult Nasal Type Extranodal NK+T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Grade III Lymphomatoid Granulomatosis|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK+T-cell Lymphoma|Contiguous Stage II Adult Burkitt Lymphoma|Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Contiguous Stage II Adult Lymphoblastic Lymphoma|Contiguous Stage II Grade 1 Follicular Lymphoma|Contiguous Stage II Grade 2 Follicular Lymphoma|Contiguous Stage II Grade 3 Follicular Lymphoma|Contiguous Stage II Mantle Cell Lymphoma|Contiguous Stage II Marginal Zone Lymphoma|Contiguous Stage II Small Lymphocytic Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncontiguous Stage II Adult Burkitt Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Grade 3 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia+Lymphoma|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides+Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent+Refractory Childhood Hodgkin Lymphoma|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage I Adult Burkitt Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Mixed Cell Lymphoma|Stage I Adult Diffuse Small Cleaved Cell Lymphoma|Stage I Adult Hodgkin Lymphoma|Stage I Adult Immunoblastic Large Cell Lymphoma|Stage I Adult Lymphoblastic Lymphoma|Stage I Adult T-cell Leukemia+Lymphoma|Stage I Childhood Anaplastic Large Cell Lymphoma|Stage I Childhood Hodgkin Lymphoma|Stage I Childhood Large Cell Lymphoma|Stage I Childhood Lymphoblastic Lymphoma|Stage I Childhood Small Noncleaved Cell Lymphoma|Stage I Cutaneous T-cell Non-Hodgkin Lymphoma|Stage I Grade 1 Follicular Lymphoma|Stage I Grade 2 Follicular Lymphoma|Stage I Grade 3 Follicular Lymphoma|Stage I Mantle Cell Lymphoma|Stage I Marginal Zone Lymphoma|Stage I Small Lymphocytic Lymphoma|Stage IA Mycosis Fungoides+Sezary Syndrome|Stage IB Mycosis Fungoides+Sezary Syndrome|Stage II Adult Hodgkin Lymphoma|Stage II Adult T-cell Leukemia+Lymphoma|Stage II Childhood Anaplastic Large Cell Lymphoma|Stage II Childhood Hodgkin Lymphoma|Stage II Childhood Large Cell Lymphoma|Stage II Childhood Lymphoblastic Lymphoma|Stage II Childhood Small Noncleaved Cell Lymphoma|Stage II Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IIA Mycosis Fungoides+Sezary Syndrome|Stage IIB Mycosis Fungoides+Sezary Syndrome|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Mixed Cell Lymphoma|Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Stage III Adult Hodgkin Lymphoma|Stage III Adult Immunoblastic Large Cell Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Adult T-cell Leukemia+Lymphoma|Stage III Childhood Anaplastic Large Cell Lymphoma|Stage III Childhood Hodgkin Lymphoma|Stage III Childhood Large Cell Lymphoma|Stage III Childhood Lymphoblastic Lymphoma|Stage III Childhood Small Noncleaved Cell Lymphoma|Stage III Cutaneous T-cell Non-Hodgkin Lymphoma|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IIIA Mycosis Fungoides+Sezary Syndrome|Stage IIIB Mycosis Fungoides+Sezary Syndrome|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia+Lymphoma|Stage IV Childhood Anaplastic Large Cell Lymphoma|Stage IV Childhood Hodgkin Lymphoma|Stage IV Childhood Large Cell Lymphoma|Stage IV Childhood Lymphoblastic Lymphoma|Stage IV Childhood Small Noncleaved Cell Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Stage IVA Mycosis Fungoides+Sezary Syndrome|Stage IVB Mycosis Fungoides+Sezary Syndrome|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenström Macroglobulinemia
|
March 2014 | Early Phase 1 |
| NCT00253487 | Children´s Hospital Medical Center, Cincinnati|National Cancer Institute (NCI) |
Brain and Central Nervous System Tumors
|
August 2005 | Not Applicable |
| NCT00458250 | Tehran University of Medical Sciences |
Leukemia, Myeloid, Acute|Leukemia, Lymphoblastic, Acute
|
September 2006 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL ( 203.00 mM ; Need ultrasonic)
H 2 O : 1 mg/mL ( 4.06 mM ; ultrasonic and warming and heat to 80°C)
Preparing
Stock Solutions
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0601 mL | 20.3004 mL | 40.6009 mL |
| 5 mM | 0.8120 mL | 4.0601 mL | 8.1202 mL |
| 10 mM | 0.4060 mL | 2.0300 mL | 4.0601 mL |
*
Please refer to the solubility information to select the appropriate solvent.
In Vivo:
*
All of the co-solvents are available by MCE.
References
- [1] Probin V, et al. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65. Epub 2007 Mar 31.
- [2] Mattan Levi, et al. Treosulfan induces distinctive gonadal toxicity compared with busulfan. Oncotarget. 2018 Apr 10;9(27):19317-19327.
- [3] Janka Reimer, et al. Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis. Eur J Clin Pharmacol. 2012 Jun;68(6):923-35.
- [4] Choi YJ, et al. Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner. FEBS Lett. 2004 Sep 24;575(1-3):41-51.
- [5] Yoshida M, et al. Reduction of primordial follicles caused by maternal treatment with busulfan promotes endometrial adenocarcinoma development in donryu rats. J Reprod Dev. 2005 Dec;51(6):707-14. Epub 2005 Sep 22.
Synonyms
1,4-Butanediol, 1,4-dimethanesulfonate
1,4-Butanediol, dimethanesulfonate
Methanesulfonic acid, tetramethylene ester
GT 41
NSC 750
CB 2041
1,4-Bis(methanesulfonoxy)butane
Busulphan
1,4-Dimethanesulfonoxybutane
1,4-Dimethylsulfonyloxybutane
Mablin
Mitostan
Myelosan
Myleran
Tetramethylene bis[methanesulfonate]
Busulfan
Misulban
Mielosan
Mileran
Milecitan
Sulfabutin
1,4-Bis(methanesulfonyloxy)butane
Leucosulfan
Mylecytan
Mielucin
1,4-Butanediol dimesylate
Glyzophrol
Butane-1,4-diyl bis(methanesulfonate)
1,4-Dibutanediol dimethanesulfonate
Busulfex
GT 2041
Myeloleukon
X 149
Sulphabutin
2041CB
AN 33501
Mielevcin
NCI C01592
Citosulfan
Busilvex
Myran
4-Methylsulfonyloxybutyl methanesulfonate
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