[CAS NO. 550-24-3] Embelin
PRODUCTS SPECIFICATIONS [550-24-3]
DESCRIPTION [550-24-3]
Overview
| MDL | MFCD00016369 |
|---|---|
| Molecular Weight | 294.39 |
| Molecular Formula | C17H26O4 |
| SMILES | O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O |
3 Publications Citing Use of MCE
Summary
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor ( IC 50 =4.1 μM), inhibits cell growth, induces apoptosis , and activates caspase-9 in prostate cancer cells with high levels of XIAP . Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells [1] [2] [3] .
IC50 & Target
|
XIAP 4.1 μM (IC 50 ) |
In Vitro
Embelin (Embelic acid) has a minimal effect on normal prostate epithelial and fibroblast cells with low levels of XIAP [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 169.84 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3969 mL | 16.9843 mL | 33.9685 mL |
| 5 mM | 0.6794 mL | 3.3969 mL | 6.7937 mL |
| 10 mM | 0.3397 mL | 1.6984 mL | 3.3969 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.49 mM); Clear solution
References
- [1] Nikolovska-Coleska Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47(10):
- [2] Ahn KS, et al. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol.
- [3] Lee YJ, et al. XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017;32(11):2371-2378.
Synonyms