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[CAS NO. 5536-17-4] Vidarabine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B0277 |
| Brand: | MCE |
| CAS: | 5536-17-4 |
Overview
| MDL | MFCD00065471 |
|---|---|
| Molecular Weight | 267.24 |
| Molecular Formula | C10H13N5O4 |
| SMILES | NC1=C(N=CN2[C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O3)C2=NC=N1 |
5 Publications Citing Use of MCE
Summary
IC50 & Target
|
HSV-2 11.3 μg/mL (IC 50 ) |
HSV-1 9.3 μg/mL (IC 50 ) |
In Vitro
Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00000985 | National Institute of Allergy and Infectious Diseases (NIAID) |
Herpes Simplex|HIV Infections
|
Phase 3 |
Appearance
Solid
Source
Streptomyces
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 187.10 mM ; Need ultrasonic)
H 2 O : 0.67 mg/mL ( 2.51 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7420 mL | 18.7098 mL | 37.4195 mL |
| 5 mM | 0.7484 mL | 3.7420 mL | 7.4839 mL |
| 10 mM | 0.3742 mL | 1.8710 mL | 3.7420 mL |
References
- [1] Whitley, R., et al., Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs, 1980. 20(4): p. 267-82.
- [2] Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006;72(2):157-161.
- [3] Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.
Synonyms
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