[CAS NO. 556803-08-8] TCN 213
PRODUCTS SPECIFICATIONS [556803-08-8]
DESCRIPTION [556803-08-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 376.54 |
| Molecular Formula | C18H24N4OS2 |
| SMILES | O=C(CSC1=NN=C(NCC2=CC=CC=C2)S1)NCC3CCCCC3 |
Summary
TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC 50 s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones [1] [2] .
IC50 & Target
|
GluN1/GluN2A NMDAR 0.55-40 μM (IC 50 ) |
In Vitro
TCN 213 (30 µM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 250 mg/mL ( 663.94 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6558 mL | 13.2788 mL | 26.5576 mL |
| 5 mM | 0.5312 mL | 2.6558 mL | 5.3115 mL |
| 10 mM | 0.2656 mL | 1.3279 mL | 2.6558 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution
References
- [1] McKay, S et al. “Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.” British journal of pharmacology vol. 166,3 (2012): 924-37.
- [2] Edman S, et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9.