[CAS NO. 55854-43-8] ES9-17
PRODUCTS SPECIFICATIONS [55854-43-8]
DESCRIPTION [55854-43-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 318.21 |
| Molecular Formula | C10H8BrNO2S2 |
| SMILES | O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O |
Summary
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain ( CHC ). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants . ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings [1] [2] .
IC50 & Target
In Vitro
ES9-17 (0-100 μM; 30 min) inhibits the uptake of the lipophilic styryl endocytic tracer dye (FM4-64), with an EC
50
value of 13 μM
[1]
.
ES9-17 (30 μM; 30 min) doesn’t deplete cellular ATP
[1]
.
ES9-17 (30 μM; 30 min) also reduces the uptake of transferrin in HeLa cells
[1]
.
ES9-17 targets to CHC and mediates transport of materials among organelles without causing cytoplasmic acidification
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15(6):641-649.
- [2] Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113.