[CAS NO. 55916-51-3] Polyphyllin VI

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PRODUCTS SPECIFICATIONS [55916-51-3]

Catalog

HY-N0816

Brand

MCE

CAS

55916-51-3

DESCRIPTION [55916-51-3]

Overview

MDL	-
Molecular Weight	738.90
Molecular Formula	C39H62O13
SMILES	O[C@]1([C@@]2([H])O[C@]3(CC[C@@H](C)CO3)[C@H]1C)[C@]([C@@]4([H])C2)(CC[C@@]5([H])[C@@]4([H])CC=C6[C@@]5(CC[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]7O)([H])[C@@H]7O[C@@](O[C@@H](C)[C@H](O)[C@H]8O)([H])[C@@H]8O)C6)C)C

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Mediators Inflamm. 2022 Apr 21;2022:8007078.

Summary

Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis ^[1] ^[2] . Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[3] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 135.34 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3534 mL	6.7668 mL	13.5336 mL
5 mM	0.2707 mL	1.3534 mL	2.7067 mL
10 mM	0.1353 mL	0.6767 mL	1.3534 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (1.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (1.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (1.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-

(3β,25R)-17-Hydroxyspirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

Pennogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside

Polygonatoside B³

Polyphyllin VI

Paris VI

Saponin Tb

17-Hydroxyparis V

Paris saponin VI

Pennogenin-3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucoside