[CAS NO. 56092-82-1] Ionomycincalcium

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [56092-82-1]

Catalog

HY-13434A

Brand

MCE

CAS

56092-82-1

DESCRIPTION [56092-82-1]

Overview

MDL	-
Molecular Weight	747.07
Molecular Formula	C41H70CaO9
SMILES	O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O.[Ca+2]

For research use only. We do not sell to patients.

25 Publications Citing Use of MCE

Summary

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus . Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis . Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) ^[1] ^[2] ^[3] .

IC50 & Target

Calcium ionophore ^[1]

In Vitro

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ^[1] .
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca ²⁺ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment ^[2] .
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03678610	Ibn Sina Hospital\|Banoon IVF Center\|Qena Fertility Center	Infertility	September 25, 2018	Not Applicable

Appearance

Solid

Source

Streptomyces conglobatus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 66.93 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3386 mL	6.6928 mL	13.3856 mL
5 mM	0.2677 mL	1.3386 mL	2.6771 mL
10 mM	0.1339 mL	0.6693 mL	1.3386 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2′R,5S,5′S)-octahydro-5′-[(1R)-1-hydroxyethyl]-2,5′-dimethyl[2,2′-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-

Ionomycin, calcium salt (1:1)

Calcium ionomycin