[CAS NO. 56238-63-2]  Cefuroxime sodium

Cefuroxime sodium is highly active against S. aureus (MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is against Staphylococcus aureus methicillin susceptible; S. aureus , methicillin resistant, Streptococcus pyogenes , S. pneumoniae , S. viridans , S. faecalis , and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively ^[1] .
Cefuroxime sodium (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains of S. aureus , but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.