[CAS NO. 5631-70-9] 5,7,4'-Trimethoxyflavone

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [5631-70-9]

Catalog

HY-N6818

Brand

MCE

CAS

5631-70-9

DESCRIPTION [5631-70-9]

Overview

MDL	-
Molecular Weight	312.32
Molecular Formula	C18H16O5
SMILES	COC1=C(C(C=C(C2=CC=C(OC)C=C2)O3)=O)C3=CC(OC)=C1

For research use only. We do not sell to patients.

Summary

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis , as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3 , and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner ^[1] .

IC50 & Target

Caspase-3

PARP

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 320.18 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2018 mL	16.0092 mL	32.0184 mL
5 mM	0.6404 mL	3.2018 mL	6.4037 mL
10 mM	0.3202 mL	1.6009 mL	3.2018 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-TrimethoxyflavoneIsolated from Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996.

Synonyms

4H-1-Benzopyran-4-one, 5,7-dimethoxy-2-(4-methoxyphenyl)-

Flavone, 4′,5,7-trimethoxy-

5,7-Dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

4′,5,7-Trimethoxyflavone

Tri-O-methylapigenin

Trimethylapigenin

5,7,4′-Trimethoxyapigenin

5,7,4′-Trimethoxyflavone

5,7-Dimethoxy-2-(4-methoxyphenyl)chromone

5,7-Dimethoxy-4-oxo-2-(4-methoxyphenyl)-4H-1-benzopyran

Apigenin trimethyl ether

5,7,4′-Tri-O-methylapigenin

5,7-Dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

[CAS NO. 5631-70-9] 5,​7,​4'-​Trimethoxyflavone