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[CAS NO. 566203-88-1] AZD2098
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-U00064 |
| Brand: | MCE |
| CAS: | 566203-88-1 |
Overview
| MDL | MFCD31382158 |
|---|---|
| Molecular Weight | 334.18 |
| Molecular Formula | C11H9Cl2N3O3S |
| SMILES | O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O |
3 Publications Citing Use of MCE
Summary
IC50 & Target
|
CCR4
|
In Vitro
AZD2098 potently inhibits chemokine-induced cellular responses, with pIC
50
of 7.5 and 6.3 against CCL22-induced Ca
2+
influx in hCCR4-expressing CHO cells and CCL17- or CCL22-induced chemotaxis of primary human Th2 cells respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AZD2098 (73.5-5.0 μg/kg; p.o.; BID; twice a day; 1 hour before and every 12 hours after antigen challenge) exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats, and the changes are first visible at a dose of 0.22 µmol/kg and maximal at 7.5 µmol/kg
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Brown-Norway rats [1] |
| Dosage: | 73.5 µg/kg, 250.6 µg/kg, 735.2 µg/kg, 1.0 mg/kg, 2.5 mg/kg, 5.0 mg/kg |
| Administration: | Oral administration; twice a day; 1 hour before and every 12 hours after antigen challenge |
| Result: | Exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 299.24 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9924 mL | 14.9620 mL | 29.9240 mL |
| 5 mM | 0.5985 mL | 2.9924 mL | 5.9848 mL |
| 10 mM | 0.2992 mL | 1.4962 mL | 2.9924 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution
References
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