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[CAS NO. 56741-95-8] Bropirimine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W008634 |
| Brand: | MCE |
| CAS: | 56741-95-8 |
Overview
| MDL | MFCD00813905 |
|---|---|
| Molecular Weight | 266.09 |
| Molecular Formula | C10H8BrN3O |
| SMILES | O=C1NC(N)=NC(C2=CC=CC=C2)=C1Br |
Summary
Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7) . Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract [1] [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 187.91 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7581 mL | 18.7906 mL | 37.5813 mL |
| 5 mM | 0.7516 mL | 3.7581 mL | 7.5163 mL |
| 10 mM | 0.3758 mL | 1.8791 mL | 3.7581 mL |
References
- [1] Suzuki H, et al. Bropirimine inhibits osteoclast differentiation through production of interferon-β. Biochem Biophys Res Commun. 2015;467(1):146‐151.
- [2] Sarosdy MF, et al. Oral bropirimine immunotherapy of bladder carcinoma in situ after prior intravesical bacille Calmette-Guérin. Urology. 1998;51(2):226‐231.
Synonyms
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