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Catalog: | HY-W010388 |
Brand: | MCE |
CAS: | 57-00-1 |
MDL | MFCD00004282 |
---|---|
Molecular Weight | 131.14 |
Molecular Formula | C4H9N3O2 |
SMILES | O=C(O)CN(C)C(N)=N |
Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
Microbial Metabolite
|
Human Endogenous Metabolite
|
NCT Number | Sponsor | Condition | Start Date | Phase |
---|---|---|---|---|
NCT01175616 | University of Utah |
Major Depressive Disorder
|
September 2012 | Phase 4 |
NCT00313417 | Herzog Hospital|Beersheva Mental Health Center |
Major Depressive Disorder
|
January 2007 | Phase 4 |
NCT04290819 | University of Regina |
Performance Enhancing Product Use
|
February 15, 2019 | Not Applicable |
NCT02047864 | University of Saskatchewan |
Osteoporosis|Sarcopenia
|
January 2014 | Not Applicable |
NCT01163370 | University of Sao Paulo |
Osteopenia|Osteoporosis
|
July 2010 | Not Applicable |
NCT03006861 | University of Saskatchewan|University of Guelph|University of Prince Edward Island |
Muscle Weakness
|
December 2016 | Not Applicable |
NCT00355576 | Columbia University|ALS Association|Pfizer |
Amyotrophic Lateral Sclerosis
|
July 2006 | Phase 2 |
NCT03194334 | University Ghent |
Dietary Modification
|
December 2012 | Not Applicable |
NCT00069186 | The Avicena Group |
Amyotrophic Lateral Sclerosis (ALS)
|
June 2003 | Phase 3 |
NCT02062086 | University Hospital, Toulouse |
Sarcopenia
|
June 2014 | Not Applicable |
NCT01655030 | University of Sao Paulo |
Bipolar I Disorder|Current Episode Depressed
|
July 2012 | Not Applicable |
NCT01894737 | Maastricht University Medical Center |
Muscle Loss
|
October 2013 | Not Applicable |
NCT03987217 | University of Utah|National Cancer Institute (NCI) |
Fatigue|Metastatic Prostate Carcinoma|Sedentary Lifestyle|Stage IV Prostate Cancer AJCC (American Joint Committee on Cancer) v8|Stage IVA Prostate Cancer AJCC (American Joint Committee on Cancer) v8|Stage IVB Prostate Cancer AJCC (American Joint Committee on Cancer) v8
|
June 17, 2019 | Early Phase 1 |
NCT00005674 | National Center for Research Resources (NCRR)|Muscular Dystrophy Association |
Amyotrophic Lateral Sclerosis
|
Phase 2 | |
NCT03003988 | Texas A&M University|Nutrabolt |
Dietary Supplementation
|
September 2014 | Not Applicable |
NCT03350282 | University of Novi Sad, Faculty of Sport and Physical Education |
Energy Metabolism
|
December 1, 2016 | Not Applicable |
NCT00018109 | National Center for Research Resources (NCRR)|Children´s National Research Institute |
Muscular Dystrophy, Duchenne
|
Phase 3 | |
NCT00026988 | National Center for Complementary and Integrative Health (NCCIH) |
Huntington´s Disease
|
October 2001 | Phase 1|Phase 2 |
NCT04734626 | Children´s Hospital of Philadelphia |
Mitochondrial Diseases
|
May 25, 2021 | |
NCT05201651 | University of Regina |
Young Healthy Adults (no Medical Condition+Disease)
|
February 10, 2022 | Early Phase 1 |
NCT02356107 | Perry Renshaw|University of Utah |
Major Depressive Disorder
|
April 2015 | Phase 4 |
NCT04498078 | University of Novi Sad, Faculty of Sport and Physical Education |
Autism Spectrum Disorder
|
January 15, 2022 | Not Applicable |
NCT02370212 | University of British Columbia |
Healthy
|
March 2015 | Not Applicable |
NCT02463305 | University of Colorado, Denver |
Colitis, Ulcerative
|
August 2022 | Early Phase 1 |
NCT00348933 | University of California, San Diego|Baylor College of Medicine|Rady Children´s Hospital, San Diego|Boston Children´s Hospital|Greenwood Genetic Center|Rare Diseases Clinical Research Network |
Angelman Syndrome|Nervous System Diseases
|
July 2006 | Not Applicable |
NCT04665804 | Foundation University Islamabad |
Knee Osteoarthritis
|
June 10, 2020 | Not Applicable |
NCT00729755 | Ewha Womans University |
Major Depressive Disorder
|
August 2008 | Not Applicable |
NCT02948244 | Murdoch Childrens Research Institute |
Facio-Scapulo-Humeral Dystrophy|FSHD2|FSHD1
|
October 31, 2017 | Not Applicable |
NCT03941678 | University of Saskatchewan|University of Regina |
Stroke
|
May 30, 2019 | Not Applicable |
NCT03530202 | University of Regina |
Sarcopenia
|
January 1, 2018 | Phase 2 |
NCT05562232 | Psychiatric Research Unit, Region Zealand, Denmark|University of Southern Denmark |
Mild Traumatic Brain Injury|Concussion, Brain
|
October 1, 2022 | Not Applicable |
NCT01472393 | University of Sao Paulo|AlzChem AG |
Postmenopausal Women
|
November 2011 | Not Applicable |
NCT01164020 | University of Sao Paulo |
Cognition|Aging
|
August 2010 | Not Applicable |
NCT01367717 | Beth Israel Medical Center |
Acute Kidney Injury
|
May 2009 | Not Applicable |
NCT03678857 | Brandon University |
Healthy
|
September 15, 2018 | Not Applicable |
NCT05451498 | Rocky Mountain University of Health Professions|Lindenwood University|Mayo Clinic|Western Michigan University |
Healthy
|
February 9, 2022 | Not Applicable |
NCT05109039 | University of Idaho |
Creatine
|
September 27, 2021 | Not Applicable |
NCT02290275 | University of Manitoba |
Osteoarthritis, Knee
|
January 2015 | Not Applicable |
NCT03039829 | Texas A&M University|Nutrabolt |
Nutritional Supplements
|
January 2016 | Not Applicable |
NCT00851006 | University of Utah|AlzChem, LLC |
Major Depressive Disorder
|
April 2009 | Phase 2 |
NCT00749983 | University of Sao Paulo |
Knee Osteoarthritis|Fibromyalgia
|
June 2009 | Not Applicable |
NCT05272969 | LMU Klinikum |
Pompe Disease (Late-onset)|Inclusion Body Myositis|Spinal Muscular Atrophy Type 3|FSHD
|
March 31, 2022 | |
NCT00484627 | National Center for Complementary and Integrative Health (NCCIH) |
HIV Infections
|
August 2001 | Phase 2 |
NCT00592995 | Massachusetts General Hospital |
Huntington Disease
|
December 2007 | Phase 2 |
NCT04471792 | Florida State University |
Peripheral Arterial Disease
|
May 12, 2020 | Phase 2 |
NCT01213719 | University of Sao Paulo |
Healthy Subjects
|
October 2010 | Not Applicable |
NCT02374112 | Center for Health, Exercise and Sport Sciences, Serbia |
Chronic Fatigue Syndrome
|
January 2016 | Not Applicable |
NCT00992043 | University of Sao Paulo |
Diabetes|Renal Function
|
October 2009 | Not Applicable |
NCT04298840 | Texas Tech University|Legion Athletics, Inc |
Dihydrotestosterone|Testosterone|Hair Loss
|
April 2020 | Not Applicable |
NCT04504253 | University of Utah |
Major Depressive Disorder
|
August 3, 2020 | Phase 3 |
NCT03433651 | Mike O´Callaghan Military Hospital |
Depression
|
January 1, 2019 | Phase 4 |
NCT01057680 | University of Saskatchewan |
Osteoporosis|Sarcopenia
|
January 2010 | Phase 3 |
NCT02188849 | University of Chile |
Muscle Weakness
|
October 2014 | Phase 3 |
NCT02094781 | GlaxoSmithKline |
Nutritional Status
|
December 2013 | Phase 1 |
NCT01725503 | The Cleveland Clinic |
Creatine Synthesis in Healthy Subjects
|
January 2010 | Not Applicable |
NCT01381354 | University of Iowa|Direct MS Canada|DJO Incorporated|Pinnaclife Inc.|TZ Press, LLC |
Multiple Sclerosis
|
October 2010 | Phase 1 |
NCT01803230 | University of Sao Paulo |
Healthy
|
February 2013 | Not Applicable |
NCT00551434 | Boston University |
Coronary Artery Disease
|
August 2002 | Not Applicable |
NCT00797407 | The Cleveland Clinic |
Hypercholesterolemia|Aches|Cramps|Weakness
|
August 2006 | Not Applicable |
NCT02993874 | State University of Maringá|Fundação de Amparo à Pesquisa do Estado do Amazonas |
Intermittent Claudication
|
June 26, 2017 | Not Applicable |
NCT05148208 | University Medical Center Groningen |
Dialysis; Complications
|
January 1, 2022 | Not Applicable |
NCT01147575 | Medical University of Vienna |
Rett Syndrome
|
January 2005 | Not Applicable |
NCT00140192 | Beersheva Mental Health Center|National Alliance for Research on Schizophrenia and Depression |
Schizophrenia
|
September 2004 | Phase 3 |
NCT02134808 | Perry Renshaw|University of Utah |
Major Depressive Disorder
|
November 21, 2014 | Phase 4 |
NCT02099357 | Universidade do Porto |
Spinal Cord Injuries
|
September 2014 | Not Applicable |
NCT04007731 | Zala Jenko Praznikar|University of Primorska |
Muscle Mass|Inflammation|Regeneration Muscle
|
July 1, 2019 | Not Applicable |
NCT01217320 | University of Sao Paulo |
Juvenile Systemic Lupus Erythematosus|Juvenile Dermatomyositis
|
January 2011 | Not Applicable |
NCT01601210 | Perry Renshaw|University of Utah |
Major Depressive Disorder
|
June 2012 | Early Phase 1 |
NCT05329480 | Radford University |
Cardiac Function and Hemodynamics
|
February 9, 2022 | Not Applicable |
NCT03062683 | RWTH Aachen University |
Syncope|Lactate Blood Increase
|
January 1, 2017 | |
NCT05383833 | University of Kansas Medical Center|Alzheimer´s Association |
Alzheimer´s Disease
|
November 30, 2022 | Not Applicable |
NCT01502813 | Deborah Yurgelun-Todd|University of Utah |
Cognitive Benefits
|
February 1, 2012 | Not Applicable |
NCT04423887 | Foundation University Islamabad |
Knee Osteoarthritis
|
June 10, 2020 | Not Applicable |
NCT04207359 | The University of Texas Health Science Center at San Antonio|The Claude D. Pepper Older Americans Independence Centers |
Breast Cancer|Chemotherapy Effect|Muscle Weakness|Muscle Loss|Exercise
|
September 30, 2020 | Not Applicable |
NCT01411150 | Massachusetts General Hospital|National Institutes of Health (NIH) |
Huntington´s Disease
|
May 2009 | Phase 2 |
NCT00465140 | University of Sao Paulo |
Renal Insufficiency
|
January 2004 | Not Applicable |
NCT00070993 | National Center for Complementary and Integrative Health (NCCIH)|Office of Dietary Supplements (ODS) |
Amyotrophic Lateral Sclerosis
|
December 2002 | Phase 2 |
NCT02519751 | GlaxoSmithKline |
Sports Nutritional Sciences
|
October 2014 | Not Applicable |
NCT02058654 | GlaxoSmithKline |
Nutritional Status
|
December 1, 2013 | Phase 1 |
NCT00473902 | Hamilton Health Sciences Corporation|McMaster University |
Sarcopenia
|
August 2003 | Not Applicable |
NCT00712426 | Massachusetts General Hospital|University of Rochester|National Center for Complementary and Integrative Health (NCCIH) |
Huntington´s Disease
|
September 2009 | Phase 3 |
NCT03000582 | Texas A&M University|Nutrabolt |
Dietary Modification
|
June 2014 | Not Applicable |
NCT01890382 | University of Sao Paulo |
Frail Elderly Syndrome
|
October 1, 2015 | Not Applicable |
NCT01411163 | Massachusetts General Hospital|National Institutes of Health (NIH) |
Huntington´s Disease
|
April 2010 | Phase 2 |
NCT03224780 | Beni-Suef University |
Placenta Accreta
|
June 1, 2017 | |
NCT01050556 | Columbia University|National Cancer Institute (NCI) |
High Blood Arsenic Due to Chronic Arsenic Exposure
|
September 2010 | Phase 4 |
NCT05014659 | Florida State University |
Endothelial Dysfunction|Oxidative Stress
|
October 17, 2020 | Not Applicable |
NCT01514630 | Perry Renshaw|University of Utah |
Depression|Substance Abuse|Substance Use|Neuroimaging|Dual Diagnosis
|
January 2013 | Phase 4 |
NCT00081250 | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) |
Anorexia|Cachexia|Unspecified Adult Solid Tumor, Protocol Specific|Weight Changes
|
December 2004 | Phase 3 |
NCT03186053 | Chinese Academy of Medical Sciences, Fuwai Hospital |
Heart Valve Diseases
|
June 15, 2017 | Not Applicable |
NCT02961972 | National Institute of Cardiology, Laranjeiras, Brazil |
Endothelial Dysfunction|Hyperhomocysteinemia
|
January 2015 | Not Applicable |
NCT02661334 | David Grant U.S. Air Force Medical Center |
Physical Fitness
|
August 1, 2015 | Not Applicable |
NCT01817673 | University of Sao Paulo |
Healthy Persons
|
July 2011 | Not Applicable |
NCT04058002 | University of Sao Paulo General Hospital |
Knee Osteoarthritis
|
August 15, 2019 | Not Applicable |
NCT02568878 | Montana State University |
Depression|Anxiety|Methamphetamine Dependence
|
November 2015 | Phase 3 |
NCT02945241 | Mayo Clinic |
Methicillin-resistant Staphylococcus Aureus|Sepsis|Critical Illness
|
April 2014 | Phase 1 |
NCT03202095 | University of Utah |
Major Depressive Disorder
|
August 1, 2017 | Phase 4 |
NCT04286178 | The Hospital for Sick Children |
Myositis, Juvenile
|
April 6, 2021 | Not Applicable |
NCT01767844 | Bangor University |
Rheumatoid Arthritis
|
January 2013 | Not Applicable |
NCT02192931 | Perry Renshaw|University of Utah |
Depression|Dual Diagnosis|Drug Addiction
|
September 2014 | Phase 4 |
NCT05589064 | Universite de Moncton|New Brunswick Health Research Foundation |
Brain Injury Traumatic Mild
|
October 2022 | Not Applicable |
NCT01025518 | Danish Head and Neck Cancer Group|Danish Center for Interventional Research in Radiation Oncology (CIRRO) |
Head and Neck Neoplasms
|
September 2009 | Not Applicable |
NCT00449865 | University of Rochester|National Institute of Neurological Disorders and Stroke (NINDS) |
Parkinson´s Disease
|
March 2007 | Phase 3 |
NCT00016653 | Cooperative International Neuromuscular Research Group |
Muscular Dystrophy, Duchenne
|
June 2000 | Phase 2|Phase 3 |
NCT04395183 | University of Utah |
Major Depressive Disorder
|
March 1, 2021 | Phase 2 |
NCT04086381 | Maastricht University |
Diet-induced Thermogenesis|Brown Adipose Tissue Activation
|
May 1, 2018 | Not Applicable |
NCT01257581 | Nazem Atassi|ALS Therapy Alliance|State University of New York - Upstate Medical University|Massachusetts General Hospital |
Amyotrophic Lateral Sclerosis
|
March 2011 | Phase 2 |
NCT00063193 | University of Rochester|National Institute of Neurological Disorders and Stroke (NINDS) |
Parkinson´s Disease
|
May 2003 | Phase 2 |
NCT04423432 | Foundation University Islamabad|Isra University |
Knee Osteoarthritis
|
January 1, 2020 | Not Applicable |
NCT01412151 | Massachusetts General Hospital |
Huntington´s Disease (HD)
|
April 2005 | Phase 2 |
NCT02189915 | Perry Renshaw|University of Utah |
Depression|Dual Diagnosis|Substance Use
|
January 2012 | Not Applicable |
NCT02922725 | Brent Michael Kious, MD, PhD|University of Utah |
Major Depressive Disorder
|
November 2016 | Phase 4 |
NCT03352128 | Vrije Universiteit Brussel |
Healthy|Creatine Supplementation
|
September 10, 2018 | Not Applicable |
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
H 2 O : 6.25 mg/mL ( 47.66 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 7.6254 mL | 38.1272 mL | 76.2544 mL |
5 mM | 1.5251 mL | 7.6254 mL | 15.2509 mL |
10 mM | 0.7625 mL | 3.8127 mL | 7.6254 mL |
Add each solvent one by one: PBS
Solubility: 20 mg/mL (152.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
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