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[CAS NO. 57-83-0] Progesterone

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Catalog:	HY-N0437
Brand:	MCE
CAS:	57-83-0

Overview

MDL	-
Molecular Weight	314.46
Molecular Formula	C21H30O2
SMILES	CC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O

For research use only. We do not sell to patients.

13 Publications Citing Use of MCE

[1]Nat Chem Biol. 2022 Aug 18.
[2]Biosens Bioelectron. 12 July 2022, 114548.
[3]Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119.
[4]J Med Chem. 2022 Nov 18.
[5]Hum Reprod. 2019 May 1;34(5):804-812.
[6]Eur J Med Chem. 2022 Apr 20;237:114382.
[7]Eur J Med Chem. 2019 Mar 22;171:265-281.
[8]Acta Pharmacol Sin. 2022 Sep;43(9):2429-2438.
[9]J Anim Sci Biotechnol. 2023 Jan 5;14(1):6.
[10]J Neurosci Methods. 2018 Sep 1;307:240-247.
[11]Exp Ther Med. February 17, 2022.
[12]Patent. US20200129476A1
[13]Patent. US20200078369A1

Summary

Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

IC50 & Target

Human Endogenous Metabolite

In Vivo

Progesterone (Injections; 1 mg; three consecutive daily) stimulates vessel maturation in the mouse endometrium ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult female mice (7-13 wk, 18-28 g) ^[4]
Dosage:	1 mg
Administration:	Injections; three consecutive daily
Result:	Stimulated vessel maturation in the mouse endometrium.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01465373	Fertility Centers of Illinois\|Ferring Pharmaceuticals	Infertility	February 2010	Phase 4
NCT03317548	Chung Shan Medical University	Infertility, Female\|Reproductive Disorder	May 1, 2017
NCT04707430	Sezcan Mumusoglu\|Hacettepe University	Relationship of Progesterone Levels and Pregnancy	August 1, 2020
NCT03088046	Institut Universitari Dexeus	Anovulation\|Polycystic Ovary Syndrome\|Hyperandrogenism	February 2014	Not Applicable
NCT03040830	Mansoura Integrated Fertility Center	Progesterone Luteal Support in ICSI\|Embryo Transfer	November 1, 2015	Phase 4
NCT02316626	Roberta Venturella\|University Magna Graecia	Infertility	December 2014	Phase 4
NCT01177904	Instituto Valenciano de Infertilidad, IVI VALENCIA	All Patients Which Show a Gestational Sac in Their Uterus in the First US Are Included in This Study and Randomized.	January 2009	Phase 4
NCT01249274	Yale University\|National Institute on Drug Abuse (NIDA)	Cocaine Abuse\|Cocaine Dependence	February 2011	Not Applicable
NCT03637062	QH Medical Technology Ltd.	High Risk Pregnancy	December 1, 2023	Not Applicable
NCT01773772	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Female Puberty	February 8, 2005	Phase 1
NCT01428245	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Hyperandrogenemia\|Polycystic Ovary Syndrome	April 22, 2011	Not Applicable
NCT00530582	Max-Planck-Institute of Psychiatry\|Dr. Kade+Besins Pharma GmbH, Rigistr. 2, 12277 Berlin	Healthy\|Postmenopausal	November 2003	Phase 4
NCT00001481	National Institute of Mental Health (NIMH)\|National Institutes of Health Clinical Center (CC)	Postpartum Depression	April 26, 1996	Phase 2
NCT00843570	University of Oxford\|Oxford Fertility Unit	Infertility	November 2009	Phase 4
NCT04777929	Second Affiliated Hospital of Wenzhou Medical University	Phthalate Exposure\|Preeclampsia\|Estrogen\|Progestin	September 1, 2021
NCT03992937	Kocaeli University	Endometrial Hyperplasia Without Atypia	June 20, 2019	Not Applicable
NCT00000176	National Institute on Aging (NIA)	Alzheimer Disease\|Memory Disorders		Phase 3
NCT01293747	Productos Científicos S. A. de C. V.	Menopause	February 2011	Phase 1
NCT00343265	University of Calgary\|Calgary Health Region\|Juniper Pharmaceuticals, Inc.	Preterm Birth	June 2006	Not Applicable
NCT01046708	Universitair Ziekenhuis Brussel	Infertility	September 2008	Not Applicable
NCT02633878	Heilongjiang University of Chinese Medicine	Threatened Miscarriage	September 1, 2017	Phase 2
NCT01081652	Merck KGaA, Darmstadt, Germany	Infertility	May 2004	Phase 3
NCT04248309	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	Progesterone,Hormone Replacement Thawed Embryo Transfer Cycles	March 2020	Not Applicable
NCT01809639	Wake Forest University Health Sciences\|American Medical Society for Sports Medicine (AMSSM) Foundation	Concussion	June 2013	Phase 4
NCT04112368	University of Illinois at Chicago	Suicidal Ideation	September 15, 2020	Phase 4
NCT01112358	Merck KGaA, Darmstadt, Germany	Ovarian Stimulation	December 7, 2005	Phase 2
NCT03740204	Massachusetts General Hospital	Eating Disorders\|Hypoestrogenemia	April 13, 2019	Phase 2
NCT01929083	Indiana University\|American Heart Association	Prolonged QT Interval in EKG and Sudden Death	April 2013	Phase 2
NCT00755963	Medical University of Vienna	Hormone Replacement	May 2009	Phase 4
NCT03701490	IBSA Institut Biochimique SA	Infertility	March 12, 2019	Phase 2
NCT04837768	Cairo University	Serum Progesterone Levels\|Progesterone Supplementation\|Frozen Embryo Transfer\|Clinical Pregnancy Rates\|Ongoing Pregnancy Rates	July 27, 2021	Not Applicable
NCT03251729	Thomas Jefferson University	Premature Birth	September 22, 2017	Not Applicable
NCT02363127	Instituto Bernabeu	Infertility	February 2015	Phase 4
NCT00830765	University of Mississippi Medical Center	Preterm Birth	June 2004	Not Applicable
NCT01464697	University of British Columbia	Hot Flushes\|Night Sweats	October 2011	Phase 3
NCT05091866	Emory University\|National Cancer Institute (NCI)	Gliosarcoma\|Recurrent Glioblastoma	April 11, 2022	Early Phase 1
NCT04997525	Copenhagen University Hospital at Herlev\|Copenhagen University Hospital, Hvidovre	Infertility	April 20, 2021	Phase 4
NCT03729869	Medical University of South Carolina\|National Institutes of Health (NIH)\|National Institute on Drug Abuse (NIDA)	Cannabis Use	January 18, 2019	Phase 2
NCT00702845	Organon and Co	Infertility	December 28, 2006	Phase 3
NCT00271206	Yale University\|National Institute on Drug Abuse (NIDA)	Tobacco Use Disorder	September 2004	Phase 1
NCT03058536	Mario Henrique Burlacchini de Carvalho\|University of Sao Paulo	Preterm Birth\|Twin Pregnancy With Antenatal Problem	February 21, 2017	Phase 2\|Phase 3
NCT04225221	University of North Carolina, Chapel Hill\|National Institute of Mental Health (NIMH)	Bulimia Nervosa	February 24, 2020	Phase 2
NCT01523483	University Medical Centre Ljubljana\|Slovenian Research Agency	Preterm Birth	March 2012	Not Applicable
NCT01959464	Wake Forest University Health Sciences\|Carolinas Medical Center	Infertility\|Pregnancy	November 2008	Phase 4
NCT05128071	University of Utah	Methamphetamine-dependence\|Postpartum Abstinence	February 4, 2022	Early Phase 1
NCT02470676	Hillel Yaffe Medical Center	Preterm Birth\|Short Cervix	July 2015	Phase 2\|Phase 3
NCT05484193	Shaare Zedek Medical Center	Use of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles	June 8, 2020	Not Applicable
NCT02571296	Ghamra Military Hospital\|Ain Shams Maternity Hospital	Preterm Birth	July 2015	Phase 4
NCT01670929	Woman´s Health University Hospital, Egypt	Abortion, Habitual	September 2012	Phase 4
NCT03834883	Indiana University\|American Heart Association\|Purdue University	Long QT Syndrome\|Abnormalities, Drug-Induced	March 26, 2019	Phase 4
NCT00696111	University of Chicago\|Duke University	Polycystic Ovary Syndrome\|Obstructive Sleep Apnea	December 2007	Not Applicable
NCT01153581	Yale University\|National Heart, Lung, and Blood Institute (NHLBI)	Orthostatic Intolerance	February 2006	Phase 2
NCT00026962	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	Breast Cancer	September 1999	Phase 2
NCT00929006	University of Virginia\|National Institutes of Health (NIH)	Puberty\|Hyperandrogenism	June 2008	Early Phase 1
NCT02460302	Mount Sinai Hospital, Canada	Atrophic Vaginitis\|Menopause\|Vulvovaginal Atrophy	December 2016	Phase 2
NCT02579421	University of Minnesota	Marijuana Dependence	November 2015	Not Applicable
NCT02513940	Indiana University\|American Heart Association\|Purdue University	Long QT Syndrome	May 2016	Phase 4
NCT04722471	Instituto Bernabeu	Luteal Phase Defect	March 3, 2021
NCT00345306	Hadassah Medical Organization	Frozen Thawed Embryo Transfer	March 2007	Phase 4
NCT01441635	AbbVie (prior sponsor, Abbott)\|AbbVie	Heavy Uterine Bleeding\|Uterine Fibroids	September 8, 2011	Phase 2
NCT00919919	Rabin Medical Center\|Ferring Pharmaceuticals	Endometrial Hyperplasia\|Endometrial Cancer	June 2009	Phase 2
NCT01636336	Mclean Hospital	Nicotine Dependence	September 2008	Not Applicable
NCT01356524	Hillel Yaffe Medical Center	Infertility	July 2011	Not Applicable
NCT04087408	Moustafa Mohammed Abouelea\|Assiut University	Effect of Adding GnRHa as Luteal Phase Support in Antagonist ART Cycles	April 1, 2020	Phase 3
NCT00585520	Yale University\|National Institute on Drug Abuse (NIDA)	Cocaine Dependence	September 2007	Phase 1
NCT01428089	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Polycystic Ovary Syndrome\|Hyperandrogenism\|Normal Puberty	March 11, 2011	Phase 1
NCT02779582	University of British Columbia	Perimenopause\|Menstrual Cramps	June 2015	Phase 3
NCT03211338	Hillel Yaffe Medical Center	Obstetric Labor, Premature	July 15, 2017	Not Applicable
NCT03863613	M? ??c Hospital	Preterm Birth\|Twin Pregnancy\|Short Cervix	March 23, 2019	Not Applicable
NCT00206544	The Alfred\|Stanley Medical Research Institute\|National Health and Medical Research Council, Australia	Bipolar Disorder\|Mania\|Schizoaffective Disorder	January 2004	Phase 2
NCT02968342	Bezmialem Vakif University	Menopause\|Sexual Desire Disorder\|Hypoactive Sexual Desire Disorder	July 2016	Phase 4
NCT05112692	Mansoura University	PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries	November 2021	Not Applicable
NCT04426487	Minia University	Traumatic Brain Injury	June 20, 2020	Early Phase 1
NCT02486757	Massachusetts General Hospital	Menstruation Disturbances	April 2015	Early Phase 1
NCT00001322	National Institute of Mental Health (NIMH)\|National Institutes of Health Clinical Center (CC)	Healthy Volunteers	June 9, 1994	Phase 1\|Phase 2
NCT01798394	University of Minnesota\|National Institutes of Health (NIH)\|National Institute on Drug Abuse (NIDA)	Tobacco Use Cessation\|Tobacco Use Disorder	June 2014	Not Applicable
NCT04190927	Women´s Hormone Network	Menopause\|Perimenopausal Disorder\|Menopause Related Conditions	June 1, 2020	Phase 4
NCT02491437	Abbott\|PRA Health Sciences\|Datamap	Female Infertility	July 2015	Phase 3
NCT03130504	Assiut University	Preterm Labor	April 1, 2016	Phase 2
NCT04278508	Hillel Yaffe Medical Center	IVF	March 9, 2020	Not Applicable
NCT01608451	Tata Memorial Hospital	Locally Advanced Breast Cancer and Large Operable Breast Cancer	September 2007	Phase 3
NCT01599494	Organon and Co	Infertility	March 2014	Phase 3
NCT00719537	John Uckele\|William Beaumont Hospitals	Preeclampsia	July 2008	Not Applicable
NCT01057511	Peking Union Medical College Hospital\|Merck Serono International SA	Postmenopausal Endometrium	December 2009	Phase 1\|Phase 2
NCT01046643	University of Michigan\|National Institute on Aging (NIA)	Menopausal Syndrome	May 2010	Not Applicable
NCT03267771	Assiut University	Abortion in First Trimester	October 1, 2017	Phase 4
NCT00594217	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Normal\|PCOS	November 29, 2007	Phase 1
NCT02187224	Yale University\|United States Department of Defense\|Brain & Behavior Research Foundation	Alcohol Dependence\|Post-Traumatic Stress Disorder (PTSD)	September 1, 2016	Phase 2\|Phase 3
NCT03343795	Assiut University	Preterm Labor	July 5, 2017	Phase 4
NCT04733235	Akdeniz University	Infertility\|Female Infertility\|Frozen-thawed Embryo Transfer	July 1, 2020
NCT00294463	Erasmus Medical Center\|Organon	Postmenopause\|Osteoporosis	February 2003	Phase 4
NCT03309709	University Magna Graecia	Endometrial Polyp	October 8, 2017	Phase 3
NCT04597099	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	PCOS\|Polycystic Ovary Syndrome	December 20, 2022	Early Phase 1
NCT03774745	University of California, Davis\|Society of Family Planning	Pregnancy, Unwanted	February 11, 2019	Phase 1\|Phase 2
NCT03948022	Centrum Clinic IVF Center	Implantation; Placenta\|Pregnancy Loss\|Frozen Embryo\|Luteal Support\|Luteal Phase Defect\|Assisted Reproduction	June 30, 2021	Phase 4
NCT00703014	Organon and Co	Pregnancy\|Neonates	July 13, 2006
NCT01143064	BHR Pharma, LLC\|PRA Health Sciences\|Syneos Health	Brain Injuries	June 2010	Phase 3
NCT01546454	Oregon Health and Science University\|Medical Research Foundation, Oregon	Coronary Heart Disease	February 2012	Not Applicable
NCT00218257	University of Minnesota\|National Institute on Drug Abuse (NIDA)	Cocaine Abuse\|Cocaine-Related Disorders	July 2002	Not Applicable
NCT02696694	Instituto Valenciano de Infertilidad, IVI VALENCIA	Pregnancy	February 2016
NCT03519776	ART Fertility Clinics LLC	Progesterone Resistance	May 10, 2018
NCT03120715	Nanfang Hospital of Southern Medical University	Infertility	July 1, 2016	Phase 4
NCT00565916	Washington University School of Medicine\|National Heart, Lung, and Blood Institute (NHLBI)\|Robert Wood Johnson Foundation	Postmenopausal Syndrome	August 2004	Not Applicable
NCT01972464	Yale University\|National Institute on Drug Abuse (NIDA)	Tobacco Use Disorder	November 2013	Phase 2
NCT01058382	Charles Coddington\|Mayo Clinic	Frozen Embryo Pregnancy Rate	February 2010
NCT00108238	US Department of Veterans Affairs\|VA Office of Research and Development	Healthy	April 2003	Phase 4
NCT00696800	Organon and Co	In Vitro Fertilization	June 27, 2006	Phase 3
NCT03003949	University of North Carolina, Chapel Hill\|National Institute of Mental Health (NIMH)	Perimenopausal Disorder\|Stress, Emotional	January 24, 2017	Phase 4
NCT04170517	CARE Fertility UK	Infertility\|Infertility, Female\|IVF	January 2, 2020
NCT03202186	BHR Pharma, LLC	Menopause Related Conditions	August 1, 2017	Phase 3
NCT00805935	Ferring Pharmaceuticals	Polycystic Ovarian Syndrome\|Infertility	January 2009	Phase 4
NCT00079248	Institute of Cancer Research, United Kingdom\|National Cancer Institute (NCI)	Breast Cancer\|Hot Flashes\|Menopausal Symptoms\|Osteoporosis	March 2002	Not Applicable
NCT01425541	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Hyperandrogenemia\|Polycystic Ovary Syndrome (PCOS)	April 2000	Not Applicable
NCT00536003	begoña Martinez de Tejada\|Centre Hospitalier Universitaire Vaudois\|University Hospital Inselspital, Berne\|Basel Women´s University Hospital\|University of Zurich\|Kantonsspital Graubuenden\|Cantonal Hospital of St. Gallen\|Luzerner Kantonsspital\|Kantonsspital Winterthur KSW\|Besins Laboratory, Belgium\|Hospital Bernardino Rivadavia Buenos Aires\|Hospital Carlos G. Durand Buenos Aires\|CEMIC Buenos Aires\|Hospital Donación Francisco Santojanni\|Hospital General de Agudos Dr. Cosme Argerich\|Hospital Dr. T. Alvarez Buenos Aires\|Hospital Italiano de Buenos Aires\|Hospital J. M. Penna Buenos Aires\|Hospital Materno Infantil Ramón Sardá\|Hospital Interzonal Alberto Antranik Eurnekian, provincia Buenos Aires\|Hospital Municipal Materno Infantil Comodoro Hugo Cesar Meisner, provincia Buenos Aires\|Hospital Comunal de Tigre, provincia Buenos Aires\|Hospital Dr. Arturo Oñativia, provincia Buenos Aires\|Hospital Dr. Carlos Bocalandro, provincia Buenos Aires\|Hospital Héroes de Malvinas, provincia Buenos Aires\|Hospital Provincial Magdalena V. de Martínez\|Hospital Mariano y Luciano de la Vega, provincia Buenos Aires\|Hospital Municipal Ostaciana B. de Lavignolle, provincia Buenos Aires\|Hospital Materno Infantil de San Isidro, provincia Buenos Aires\|Hospital Virgen del Carmen, provincia Buenos Aires\|Hospital J. B. Iturraspe, Santa Fe\|Hospital Maternidad Nuestra Señora De Las Mercedes, Tucumán\|Hospital Materno Infantil San Roque, Entre Ríos\|Hospital Villa Dolores, Córdoba\|University Hospital, Geneva	Preterm Delivery\|Morbidity\|Perinatal Mortality	July 2006	Phase 3
NCT03781674	Aswan University Hospital	Twin; Pregnancy, Affecting Fetus or Newborn	January 1, 2019	Not Applicable
NCT02772120	Brigham and Women´s Hospital	Infertility		Phase 4
NCT02623881	Vietnam National University\|M? ??c Hospital	Pregnancy	March 4, 2016	Not Applicable
NCT04846218	Ain Shams University	Infertility, Female	December 2016	Not Applicable
NCT02109900	Acibadem University	Infertility\|Assisted Reproductive Technology	February 2014
NCT05062135	University of Sao Paulo General Hospital	Polycystic Ovary\|Progesterone Resistance	February 10, 2014	Not Applicable
NCT03998761	M? ??c Hospital	Infertility	June 26, 2019	Not Applicable
NCT05276531	Bezmialem Vakif University	Progesterone	April 1, 2022	Not Applicable
NCT02078869	Toronto Centre for Advanced Reproductive Technology	In Vitro Fertilization\|Embryo Transfer\|Drug Effects	March 2014	Not Applicable
NCT01353846	Instituto Valenciano de Infertilidad, IVI VALENCIA	Infertility	May 2011	Phase 4
NCT03484611	Cairo University	Invitro Fertilizaion	January 2013	Not Applicable
NCT03779451	Aswan University Hospital	Placenta Previa	January 1, 2019	Not Applicable
NCT00702234	Organon and Co	Pregnancy\|Neonates	February 15, 2007
NCT02224313	Intira Sriprasert\|TherapeuticsMD\|Eastern Virginia Medical School	Menopause	December 2015	Phase 3
NCT04128436	Hacettepe University\|Anatolia IVF and Women´s Health Center	Luteal Phase Progesterone Levels	January 1, 2019	Not Applicable
NCT03269591	Cairo University	Electromagnetic Field\|Dysmenorrhea	February 1, 2016	Not Applicable
NCT03018366	Cedars-Sinai Medical Center	Estrogen Deficiency\|Cardiovascular Disease (CVD)\|Hypothalamic Amenorrhea	January 1, 2017	Phase 2
NCT00828191	IBSA Institut Biochimique SA	In Vitro Fertilization	December 2008	Phase 3
NCT01381016	University of Colorado, Denver	Obesity\|Infertility	June 2011	Not Applicable
NCT03619707	American University of Beirut Medical Center	Sterility\|Infertility	August 1, 2018	Phase 4
NCT03725904	Peter Humaidan\|Boston IVF\|Regionshospitalet Viborg, Skive	Infertility, Female	October 24, 2018	Not Applicable
NCT02567552	IVI Barcelona	Reproductive Techniques, Assisted	May 2015	Phase 4
NCT03395665	Institut Universitari Dexeus	Infertility\|Preimplantation Genetic Diagnosis+Screening\|Miscarriage	January 2014
NCT03633175	Ain Shams University	Placenta Previa	July 5, 2018	Phase 2
NCT01811225	University of Minnesota	Nicotine Dependence\|Contraception	December 2012	Phase 2
NCT03457233	Cairo University	Invitro Fertilization	January 3, 2015	Not Applicable
NCT01589068	Mclean Hospital	Nicotine Dependence	January 2007	Not Applicable
NCT02032797	Universitair Ziekenhuis Brussel	Cryopreservation\|Embryo Implantation\|Progesteron	November 2012	Phase 4
NCT01744574	University of Minnesota\|National Institute on Drug Abuse (NIDA)	Tobacco Cessation	December 2012	Not Applicable
NCT00928213	Ben-Gurion University of the Negev\|Diagnostic Technologies Ltd.\|Perkin Elmer Inc.\|Medical University of Graz	Preeclampsia	August 2009	Phase 2\|Phase 3
NCT01927029	Universidad del Desarrollo\|Hospital Padre Hurtado\|Hospital San Borja-Arriaran	Pregnancies	August 2013	Phase 4
NCT01269450	HaEmek Medical Center, Israel	Antepartum Bleeding\|Preterm Birth	March 2011	Not Applicable
NCT03642665	Universitaire Ziekenhuizen KU Leuven\|GZA Ziekenhuizen Campus Sint-Augustinus\|Imelda Hospital, Bonheiden\|Jessa Hospital	Embryo Transfer	September 25, 2018	Phase 4
NCT01909141	Cairo University	Polycystic Ovary Syndrome\|Infertility	August 2013	Early Phase 1
NCT00702273	Organon and Co	In Vitro Fertilization	April 19, 2006
NCT04783857	University of Minnesota\|University of Arizona\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Smoking\|Smoking Cessation\|Smoking Reduction	April 14, 2022	Phase 4
NCT03860636	University of Nottingham	Infertility, Subfertility	November 26, 2018
NCT01780610	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	Infertility	January 2012	Not Applicable
NCT03720847	University of North Carolina, Chapel Hill\|National Institute of Mental Health (NIMH)	Suicidal Ideation	December 31, 2016	Phase 4
NCT05286554	Alexandria University	Female Infertility	March 17, 2022	Phase 4
NCT03430050	Medical University of South Carolina\|National Institute on Drug Abuse (NIDA)\|National Institutes of Health (NIH)	Cannabis Use Disorder\|Cannabis Withdrawal	October 16, 2017	Early Phase 1
NCT03620838	Uludag University	Ovarian Reserve\|Endometrioma	March 1, 2019
NCT02969590	Oregon Health and Science University\|Society of Family Planning	Fertility\|Contraception	March 29, 2015	Phase 4
NCT02913495	Thomas Jefferson University\|Baystate Medical Center\|George Washington University\|Vriginia Commonwealth University\|Ohio State University	Premature Birth	September 2016	Phase 4
NCT03930212	Tanta University	Threatened Abortion\|Progesterone Resistance	January 1, 2018	Phase 4
NCT01762943	University of North Carolina, Chapel Hill\|Foundation of Hope, North Carolina\|North Carolina Translational and Clinical Sciences Institute\|National Institutes of Health (NIH)\|National Alliance for Research on Schizophrenia and Depression\|National Institute of Mental Health (NIMH)	Postpartum Depression	August 2013	Not Applicable
NCT01888744	Universitair Ziekenhuis Brussel	Reproductive Endocrinology\|Fertility\|Optimal Stimulation Protocol	September 2010	Phase 4
NCT00455962	Massachusetts General Hospital\|National Institutes of Health (NIH)\|National Institute on Aging (NIA)	Premenopause\|Healthy	January 2005	Phase 1\|Phase 2
NCT02019589	TherapeuticsMD	Secondary Amenorrhea	January 20, 2014	Phase 3
NCT04665232	San Carlo Public Hospital, Potenza, Italy	Autoimmune Diseases\|Infertility	April 2014
NCT01178788	University of Modena and Reggio Emilia	Preterm Delivery\|Neonatal Complications	February 2010	Phase 3
NCT02655146	Chong Qing Reproducive and Genetic Institute	Infertility	December 2015	Phase 4
NCT00247169	Medical University of Vienna	Cervical Intraepithelial Neoplasia	August 2004	Phase 2
NCT00000466	National Heart, Lung, and Blood Institute (NHLBI)\|National Institute on Aging (NIA)\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Bone Diseases\|Cardiovascular Diseases\|Coronary Disease\|Diabetes Mellitus\|Heart Diseases\|Hypercholesterolemia\|Hypertension\|Myocardial Ischemia\|Osteoporosis\|Thrombosis\|Postmenopause	September 1987	Phase 3
NCT00946192	Massachusetts General Hospital\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Exercise-related Amenorrhea	May 2009	Phase 3
NCT05586724	Angelica Lindén Hirschberg\|Karolinska University Hospital	Menopausal Symptoms	February 25, 2022	Phase 3
NCT02304237	Ewha Womans University Mokdong Hospital\|Samsung Medical Center\|Han Wha Pharma Co., Ltd.\|Ministry of Health & Welfare, Korea	Premature Birth	December 2014	Phase 3
NCT03440359	Eastern Virginia Medical School\|Watson Pharmaceuticals	Polycystic Ovary Syndrome	July 6, 2012	Phase 2\|Phase 3
NCT04108039	Institut Universitari Dexeus	Infertility\|IVF\|Preimplantation Diagnosis	September 25, 2019	Not Applicable
NCT03181685	Andros Day Surgery Clinic	Infertility\|In Vitro Fertilization	December 20, 2016	Phase 4
NCT02254577	Shady Grove Fertility Reproductive Science Center\|Ferring Pharmaceuticals	Infertility	October 2014	Phase 4
NCT01780558	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	Infertility	January 2010	Not Applicable
NCT01031017	University of Sao Paulo	Preterm Delivery	June 2007	Phase 4
NCT02133573	Children´s Hospital of Philadelphia	Congenital Heart Disease\|Periventricular Leucomalacia\|Brain Development\|Cardiac Surgery\|Neurodevelopmental Disability\|Fetal Neuroprotection	May 2014	Phase 2
NCT01796522	Instituto de Investigacion Sanitaria La Fe	Preterm Delivery.	March 2013	Phase 3
NCT01126255	University Hospital Inselspital, Berne\|University of Bern	Vulvar Lichen Sclerosus	March 2011	Phase 2
NCT02524561	Brigham and Women´s Hospital\|National Cancer Institute (NCI)\|Kronos Longevity Research Institute\|Albert Einstein College of Medicine\|Columbia University\|Mayo Clinic\|University of California, San Francisco\|University of Utah\|University of Washington\|Yale University	Mammographic Density\|Abnormal Mammogram	September 2005	Not Applicable
NCT01602679	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Female Reproductive Physiology	May 2012	Phase 1
NCT05312190	Peking Union Medical College Hospital\|Sichuan University West China Second University Hospital\|Chongqing Medical University No.1 Affiliated Hospital\|The Second Hospital of Hebei Medical University\|Second Affiliated Hospital of Nanchang University\|Southeast University Affiliated Zhongda Hospital\|Hubei Maternal and Child Health Hospital\|Liuzhou Maternity and Child Healthcare Hospital\|Zhejiang University Medical College Affiliated Hangzhou First People´s Hospital\|Guangzhou Women and Children´s Medical Center	Menstrual Disorders	March 15, 2022	Not Applicable
NCT02114645	Zekai Tahir Burak Women´s Health Research and Education Hospital	Infertility	April 2014	Not Applicable
NCT01406197	St. Joseph´s Hospital and Medical Center, Phoenix	Preterm Labor	July 2011	Not Applicable
NCT04839627	Hospital St. Joseph, Marseille, France	Infertility	June 16, 2021
NCT02518594	The George Washington University Biostatistics Center\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Short Cervical Length	November 13, 2015	Phase 3
NCT00377923	IBSA Institut Biochimique SA	Healthy	August 2005	Phase 1
NCT04104984	Assiut University	Preterm Labour	February 15, 2020	Early Phase 1
NCT00696878	Organon and Co	In Vitro Fertilization	September 26, 2006	Phase 3
NCT05189145	Alexandria University	Female Infertility	October 1, 2019	Not Applicable
NCT02685072	Yale University\|National Cancer Institute (NCI)	Smoking Cessation	April 7, 2016	Phase 4
NCT00006399	National Center for Research Resources (NCRR)\|Alzheimer´s Association\|Pfizer\|Eisai Inc.\|National Institute on Aging (NIA)	Alzheimer Disease	September 1999	Phase 2
NCT00702546	Organon and Co	In Vitro Fertilization	December 2006
NCT00455741	Massachusetts General Hospital\|National Institute on Aging (NIA)	Postmenopause\|Aging	November 2000	Phase 1\|Phase 2
NCT03202836	Chulalongkorn University	Preterm Labor	June 29, 2017	Not Applicable
NCT03498313	University of Illinois at Chicago\|National Institute of Mental Health (NIMH)	Suicidal Ideation	July 27, 2018	Phase 4
NCT04549116	IBSA Institut Biochimique SA	Infertility	October 12, 2022	Phase 3
NCT02736032	Cairo University\|Nile Ivf Center, Cairo, Egypt\|Kamal Shaeer center of infertility	Infertility	March 2016	Phase 3
NCT04748562	Ain Shams University	Twin Pregnancy With Antenatal Problem	January 1, 2020	Phase 4
NCT05232344	University Hospital, Montpellier	Infertility	April 13, 2022	Not Applicable
NCT02338830	Mohamed Sayed Abdelhafez\|Mansoura University	Premature Labour	June 2012	Phase 4
NCT04143880	Second Affiliated Hospital, School of Medicine, Zhejiang University\|Korea University Anam Hospital\|Seoul National University Hospital\|Lishui Country People´s Hospital\|Jinhua Central Hospital\|Huizhou Municipal Central Hospital\|The Affiliated Hospital of Hangzhou Normal University	Stroke	February 1, 2020	Phase 4
NCT05481684	Bezmialem Vakif University	Infertility\|IVF\|Progesterone	August 8, 2022	Not Applicable
NCT02989519	Sanpasitthiprasong Hospital	Preterm Delivery	August 2015	Phase 3
NCT01980680	Peter Humaidan\|Regionshospitalet Viborg, Skive	Infertility	December 2014	Phase 4
NCT03068910	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Hyperandrogenism\|Polycystic Ovary Syndrome\|Puberty	July 21, 2016	Early Phase 1
NCT01790282	Mansoura Integrated Fertility Center	IVF\|Infertility	March 2013	Not Applicable
NCT01418209	Fred Hutchinson Cancer Center\|National Institute on Aging (NIA)\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|National Center for Complementary and Integrative Health (NCCIH)\|Office of Research on Women´s Health (ORWH)	Hot Flashes\|Menopause\|Vasomotor Disturbance	November 2011	Not Applicable
NCT01428193	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Polycystic Ovary Syndrome\|Hyperandrogenism	September 2006	Not Applicable
NCT02846909	Assiut University	Abortion	April 1, 2017	Phase 2
NCT02255175	University of North Carolina, Chapel Hill\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|National Institute of Mental Health (NIMH)	Perimenopausal Depression	October 1, 2015	Phase 4
NCT02697331	Ain Shams University	Preterm Birth\|Twin Dichorionic Diamniotic Placenta	April 5, 2016	Phase 3
NCT05125627	Joint Stock Company Farmak	Pharmacokinetics	August 28, 2019	Phase 1
NCT04675788	Indiana University\|Purdue University\|National Heart, Lung, and Blood Institute (NHLBI)\|Harvard University\|Cedars-Sinai Medical Center	Long QT Syndrome\|Abnormalities, Drug-Induced	September 2, 2021	Phase 4
NCT02841137	IBSA Institut Biochimique SA	Menopause	June 2016	Phase 2
NCT03366025	Institut Universitari Dexeus	Controlled Ovarian Stimulation\|Progesterone Variation on Trigger Day\|Circadian Rhythm\|Oocyte Donors	November 1, 2017
NCT03687021	Peking Union Medical College Hospital	Endometrial Receptivity;RNA; Progesterone	October 10, 2018	Early Phase 1
NCT03677336	CRG UZ Brussel\|Universitätsklinikum Hamburg-Eppendorf\|Abbott\|KU Leuven	Infertility, Female\|Infertility\|Genital Diseases, Male\|Genital Diseases, Female\|Progesterone\|Dydrogesterone\|Hormones\|Hormones, Hormone Substitutes, and Hormone Antagonists\|Physiological Effects of Drugs\|Progestins	May 1, 2019	Phase 4
NCT04758871	CRG UZ Brussel	Frozen Embryo Transfer\|Hormone Replacement Therapy\|Dydrogesterone\|Infertility, Female	March 1, 2021	Phase 4
NCT04114500	Al Baraka Fertility Hospital	Frozen Embryo Transfer	April 3, 2018
NCT04537078	El Shatby University Hospital for Obstetrics and Gynecology	Infertility, Female	September 1, 2020	Phase 3
NCT03537287	Ain Shams University	Preterm Labor	July 2016	Phase 2
NCT02788097	Antalya IVF	Progesterone Induced Endometrial Receptivity	May 2016	Not Applicable
NCT02511574	University of Sao Paulo	Preterm Labor\|Premature Birth	June 2014	Phase 4
NCT02350231	Assiut University\|Sohag University	Preterm Birth	February 1, 2014	Phase 2\|Phase 3
NCT00579553	University of Oklahoma	Infant, Premature\|Premature Birth	October 2006	Not Applicable
NCT01500863	IVI Madrid	Ovarian Hyperstimulation Syndrome	November 2011	Phase 4
NCT04300322	M? ??c Hospital\|My Duc Phu Nhuan Hospital HCMC, Vietnam\|Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam	Preterm Birth\|Short Cervix	May 1, 2020	Not Applicable
NCT03023514	Lo.Li.Pharma s.r.l	Women Infertility	March 2015	Phase 4
NCT01176175	Productos Científicos S. A. de C. V.	Infertility	August 2010	Phase 1
NCT05388656	University of North Carolina, Chapel Hill\|National Institute of Mental Health (NIMH)	Menopause\|Irritable Mood	June 15, 2022	Phase 4
NCT05125640	Joint Stock Company Farmak	Pharmacokinetics	December 13, 2019	Phase 1
NCT00656201	Brigham and Women´s Hospital\|EMD Serono	Infertility	July 2003	Phase 4
NCT04365127	Sara Ghandehari\|IBSA Institut Biochimique SA\|Cedars-Sinai Medical Center	COVID-19\|Sars-CoV2	April 27, 2020	Phase 1
NCT03340701	Thomas Jefferson University	Progesterone	November 6, 2017	Phase 1
NCT01432028	Denusa Wiltgen\|Hospital de Clinicas de Porto Alegre\|Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.\|Conselho Nacional de Desenvolvimento Científico e Tecnológico\|Federal University of Rio Grande do Sul	Postmenopause	March 2007	Not Applicable
NCT00646802	Hospital Clinic of Barcelona	Threatened Premature Labor	June 2008	Phase 4
NCT05024604	Samuel Gendy\|Assiut University	Women Health\|Contraception	September 1, 2021
NCT00000601	National Heart, Lung, and Blood Institute (NHLBI)	Angina, Unstable\|Cardiovascular Diseases\|Coronary Disease\|Heart Diseases\|Postmenopause	July 1995	Phase 3
NCT04414761	ShangHai Ji Ai Genetics & IVF Institute	IVF\|GnRH Antagonist\|PPOS	April 17, 2020	Phase 3
NCT00135902	The George Washington University Biostatistics Center\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Preterm Birth	February 2005	Phase 3
NCT03077633	Mednax Center for Research, Education, Quality and Safety	Preterm Birth\|Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2\|Cervical Incompetence\|Cervical Shortening	October 1, 2017	Phase 2\|Phase 3
NCT03565211	Ferring Pharmaceuticals	Progesterone Supplementation in Women Undergoing ART	July 26, 2018	Phase 3
NCT00048646	David Wright\|National Institute of Neurological Disorders and Stroke (NINDS)\|Emory University	Traumatic Brain Injury	May 2002	Phase 1\|Phase 2
NCT01741376	University of Minnesota	Cocaine Dependence\|Nicotine Dependence	November 2012	Not Applicable
NCT00676026	University of Pennsylvania	Healthy	May 2005	Not Applicable
NCT03540225	Chiu Yee Liona Poon\|Chinese University of Hong Kong	Premature Birth\|Twin Pregnancy	April 2020	Phase 3
NCT02329535	HaEmek Medical Center, Israel	Premature Birth	January 2015	Not Applicable
NCT00422526	King´s College Hospital NHS Trust	Preterm Birth\|Pregnancy Trimester, Second	September 2003	Phase 3
NCT04558268	Soroka University Medical Center	Recurrent Pregnancy Loss(RPL)\|Recurrent Miscarriage	December 2020	Phase 2\|Phase 3
NCT05555121	Clinique Ovo\|Ferring Pharmaceuticals	Fertility Issues\|Embryo Implantation\|Frozen Embryo Transfer	October 15, 2022	Phase 2
NCT03152942	St Stephens Aids Trust\|Action Medical Research	Premature Obstetric Labor	October 5, 2017	Phase 1
NCT01643980	Dra.Cristina Martinez Payo\|Puerta de Hierro University Hospital	Early Onset of Delivery Before 37 Weeks	August 2012	Phase 4
NCT05365464	Wake Forest University Health Sciences	Recurrent Pregnancy Loss Without Current Pregnancy	May 2022	Phase 2
NCT02406690	Reproductive Medicine Associates of New Jersey	Endometrial Dysfunction	July 31, 2015
NCT01812239	Obstetrix Medical Group\|Mednax Center for Research, Education, Quality and Safety	Premature Birth	March 2014	Phase 2\|Phase 3
NCT00685009	National Heart, Lung, and Blood Institute (NHLBI)\|Wake Forest University Health Sciences	Dementia Syndromes	January 1996
NCT01942668	TherapeuticsMD	Menopause	August 5, 2013	Phase 3
NCT00000555	National Heart, Lung, and Blood Institute (NHLBI)	Cardiovascular Diseases\|Coronary Arteriosclerosis\|Coronary Disease\|Heart Diseases\|Myocardial Ischemia\|Postmenopause	August 1996	Phase 3
NCT00802360	Ferring Pharmaceuticals	Infertility	December 2008	Phase 4
NCT04531943	Emory University\|National Institute of Allergy and Infectious Diseases (NIAID)	HIV Prevention	October 1, 2020
NCT01286246	University of Calgary	Obstetric Labor, Premature	January 2011	Phase 4
NCT03071172	GeneScience Pharmaceuticals Co., Ltd.\|Peking University Third Hospital\|The First Affiliated Hospital with Nanjing Medical University\|Women´s Hospital School Of Medicine Zhejiang University\|Xiangya Hospital of Central South University\|Sixth Affiliated Hospital, Sun Yat-sen University\|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University\|The First Affiliated Hospital of Anhui Medical University	Ovarian Hyperstimulation Syndrome	March 2017	Phase 3
NCT04725864	Vastra Gotaland Region\|Göteborg University	Infertility\|Embryo Transfer	May 1, 2021	Phase 4
NCT02970552	University of North Carolina, Chapel Hill\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	PreTerm Birth	July 1, 2017	Phase 4
NCT02272647	Mayo Clinic	Healthy	December 2014	Phase 1
NCT03734770	Universita di Verona	Progesterone\|Luteal Phase Support\|In Vitro Fertilization	January 1, 2019	Not Applicable
NCT05211583	Turgut Ayd?n\|Acibadem University	Subfertility, Female\|Ovulation Disorder	December 10, 2021
NCT00117468	Duramed Research\|Teva Branded Pharmaceutical Products R&D, Inc.	Infertility	June 2005	Phase 2
NCT02950935	IBSA Institut Biochimique SA	Threatened Abortion in First Trimester	April 4, 2017	Phase 3
NCT00822900	David Wright\|Medical University of South Carolina\|Neurological Emergencies Treatment Trials Network (NETT)\|Emory University	Traumatic Brain Injury	March 2010	Phase 3
NCT04938011	Nanjing University	Infertility	July 2021	Phase 2
NCT00029536	Beth Israel Deaconess Medical Center\|Brigham and Women´s Hospital\|Columbia University\|Dartmouth-Hitchcock Medical Center\|Emory University\|Johns Hopkins University\|Montreal Neurological Institute and Hospital\|Ohio State University\|Thomas Jefferson University\|University of Maryland\|University of Southern California\|University of Virginia\|Weill Medical College of Cornell University\|Minnesota Comprehensive Epilepsy Program	Epilepsy	October 2000	Phase 3
NCT01123538	University Hospital of North Norway	Pharmacogenomics\|Systems Biology	December 2008	Phase 4
NCT04161989	Assiut University	Small for Gestational Age at Delivery	May 1, 2020	Not Applicable
NCT00329914	Rigshospitalet, Denmark\|The Danish Medical Research Council\|The Danish Medical Society in Copenhagen\|AP Moeller Foundation	Preterm Delivery	June 2006	Phase 2
NCT03737656	Grünenthal GmbH\|Grünenthal, S.A.	Pharmacokinetics	November 1, 2018	Phase 1
NCT00946088	Stanford University	Pregnancy Complications	October 2009	Phase 2\|Phase 3
NCT01941875	University of Alberta	Infertility	July 2014	Phase 3
NCT00001259	National Institute of Mental Health (NIMH)\|National Institutes of Health Clinical Center (CC)	Premenstrual Syndrome\|Menstruation Disturbances	August 11, 1992	Phase 1
NCT00480402	Instituto Valenciano de Infertilidad, IVI VALENCIA	Preterm Birth	January 2006	Phase 3
NCT00700492	University Hospital, Gasthuisberg	Subfertility	May 2004	Not Applicable
NCT03272412	Instituto Valenciano de Infertilidad, IVI VALENCIA	Ongoing Pregnancy Rate	September 8, 2017
NCT04209543	Estetra\|ICON Clinical Research	Vasomotor Symptoms\|Menopausal Symptoms	December 30, 2019	Phase 3
NCT05061641	Caixia Liu\|Shengjing Hospital	Preterm Birth	May 1, 2021	Phase 4
NCT02372942	University of Padova	Preterm Delivery	February 2014	Phase 4
NCT00708539	Nordica Fertility Clinic\|Merck Serono International SA	IVF - Luteal Phase Support After Embryo Transfer	April 2006	Phase 4
NCT04051320	University of North Carolina, Chapel Hill\|National Institute of Mental Health (NIMH)	Perinatal Depression\|Post Partum Depression\|Depression, Postpartum\|Depression	January 2, 2020	Phase 2
NCT04507022	Rahem Fertility Center	Infertility\|Infertility, Female\|Infertility, Male	August 12, 2020	Phase 4
NCT04046185	Shanghai First Maternity and Infant Hospital	Endometrial Cancer Stage I	October 1, 2019	Early Phase 1
NCT01698164	Peking Union Medical College Hospital	Menopausal Syndrome\|Cardiovascular Disease\|Osteoporosis\|Breast Cancer	December 2008	Phase 4
NCT00152438	University of British Columbia	Menopause	September 2005	Phase 2
NCT00805207	Washington University School of Medicine	Polycystic Ovary Syndrome (PCOS)\|Obstructive Sleep Apnea\|Obesity	September 2007	Not Applicable
NCT00615550	Juniper Pharmaceuticals, Inc.\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Preterm Delivery\|Short Cervix\|Short Uterine Cervical Length	March 2008	Phase 3
NCT00086177	Juniper Pharmaceuticals, Inc.	Pregnancy	April 2004	Phase 3
NCT04865029	Tulane University	Covid19	July 22, 2021	Phase 2
NCT03470610	Thor Haahr\|Regionshospitalet Viborg, Skive	Infertility	February 1, 2018
NCT02225353	Grünenthal GmbH\|Laboratorios Andromaco S.A.	Preterm Birth	September 2, 2013	Phase 2
NCT00005108	National Heart, Lung, and Blood Institute (NHLBI)\|National Institutes of Health Clinical Center (CC)	Atherosclerosis\|Healthy\|Vascular Disease	April 2000	Phase 2
NCT00954811	Universitair Ziekenhuis Brussel\|Merck Serono International SA	Pregnancy\|Pregnancy Loss	September 2005	Phase 4
NCT05184777	Instituto Valenciano de Infertilidad, IVI VALENCIA\|MINT DIAGNOSTICS	Infertility, Female\|Reproductive Sterility	February 3, 2022	Not Applicable
NCT00632099	New York State Psychiatric Institute\|National Institute on Drug Abuse (NIDA)	Cocaine Dependence	February 2008	Phase 2\|Phase 3
NCT04008966	Cairo University	Assisted Reproduction	July 20, 2016	Phase 4
NCT03976544	CRG UZ Brussel	Miscarriage\|Frozen Embryo Transfer\|Natural Cycle\|Hormone Replacement Therapy Cycle\|Preimplantation Genetic Screening\|Euploid Embryos	May 25, 2019	Phase 4
NCT04499131	Instituto Valenciano de Infertilidad, IVI VALENCIA	Infertility, Female\|ENDOMETRIAL RECEPTIVITY	December 9, 2021	Phase 4
NCT04769401	Bezmialem Vakif University	Infertility\|IVF\|Progesterone	February 1, 2021	Not Applicable
NCT00702624	Organon and Co	Pregnancy\|Neonates	April 2007
NCT00809939	Meir Medical Center	Pregnancy	December 2010	Phase 3
NCT02467673	University Potiguar\|InBios International, Inc.\|Federal University of São Paulo	Menopausal Syndrome	January 2012	Phase 2
NCT01940653	Universitair Ziekenhuis Brussel	Progesterone Supplementation	November 2012	Phase 4
NCT01180296	Fetal Medicine Foundation	Preterm Birth	November 2006	Phase 3
NCT01850030	Abbott\|Quintiles, Inc.	Female Infertility	August 2013	Phase 3
NCT01810601	Ain Shams Maternity Hospital	Infertility	September 2009	Not Applicable
NCT02492451	Zeynep Kamil Maternity and Pediatric Research and Training Hospital	Pregnancy	June 2015	Not Applicable
NCT01954966	University of Pennsylvania\|National Institute on Drug Abuse (NIDA)	Nicotine Dependence\|Nicotine Withdrawal	November 2010	Phase 4
NCT02145767	Sir Mortimer B. Davis - Jewish General Hospital\|Canadian Institutes of Health Research (CIHR)	Miscarriage\|Preterm Birth	December 2014	Phase 2
NCT01206998	University of Rochester\|Juniper Pharmaceuticals, Inc.	Labor, Premature	July 2010	Not Applicable
NCT00732693	University of Edinburgh	Premature Ovarian Failure	February 2002	Phase 4
NCT04124913	Memorial Sisli Hospital, Istanbul	Infertility, Female\|Infertility, Male\|Embryo Transfer\|Fertilization in Vitro\|Drug Effect\|Reproductive Techniques, Assisted\|Progesterone\|Dydrogesterone	January 2, 2019	Phase 4
NCT05161338	Instituto Valenciano de Infertilidad, IVI VALENCIA	Infertility, Female	February 15, 2022	Not Applicable
NCT01225835	Ferring Pharmaceuticals\|Ferring Arzneimittel GmbH	Infertility	October 2010	Phase 4
NCT02323347	Institut Universitari Dexeus	Progesterone\|Fertilization in Vitro\|Infertility\|Pregnancy	January 2009
NCT03463252	West China Second University Hospital	Endometrial Cancer\|Atypical Endometrial Hyperplasia	April 1, 2018	Phase 2\|Phase 3
NCT02673359	Mohamed Sayed Abdelhafez\|Mansoura University	Premature Labour	February 2016	Phase 4
NCT00000295	National Institute on Drug Abuse (NIDA)\|University of Minnesota	Tobacco Use Disorder	April 1999	Phase 2
NCT05282277	University of North Carolina, Chapel Hill\|National Institute of Mental Health (NIMH)	Depression\|Psychosis\|Anhedonia	April 1, 2022	Phase 4
NCT05080569	UMC Utrecht	Pregnancy Related\|Fertility Issues\|Luteal Phase Defect\|Infertility Unexplained	December 2022	Phase 4
NCT00775242	Centro A.F. de Estudios Tecnologicos, S.A.	Menopause	April 2007	Phase 2\|Phase 3
NCT00563472	Pantarhei Bioscience	Healthy	November 2007	Phase 2
NCT02677259	One Fertility	IVF	May 2016	Phase 2
NCT03740568	Institut Universitari Dexeus\|Fundación Santiago Dexeus Font\|Dexeus Clinic Woman	Infertility\|Progesterone\|Frozen Embryo Transfer\|Euploid Embryo Transfer\|Pregnancy Outcome\|Artificial Cycle\|Ongoing Pregnancy	November 15, 2018	Not Applicable
NCT02601898	Azienda USL Ferrara	Subchorionic Hematoma in the First Trimester Pregnancy\|Miscarriage	January 2015	Phase 4
NCT04753957	Thomas Jefferson University	Pregnancy Related	January 7, 2022	Phase 1
NCT04342585	National University of Malaysia	Preterm Birth	January 1, 2023	Phase 3
NCT01147770	Universitair Ziekenhuis Brussel	Infertility	September 2008	Phase 1\|Phase 2
NCT01589081	Mclean Hospital	Nicotine Dependence	September 2008	Not Applicable
NCT04259996	Instituto Valenciano de Infertilidad, IVI VALENCIA	Infertility, Female	February 19, 2020
NCT00302731	Jeanne Drisko, MD, CNS, FACN\|Private Foundation through KU Endowment\|University of Kansas\|University of Kansas Medical Center	Menopause	February 2006	Phase 2
NCT01237535	Rabin Medical Center	Unexplained Infertility\|Mild Male Factor	November 2011	Phase 4
NCT01504139	Regionshospitalet Viborg, Skive	Progesterone Levels\|Infertility	January 2012	Phase 4
NCT03309735	Besins Healthcare\|Clinical Research Laboratory, CRO, Russia	Threatened Miscarriage	October 16, 2017
NCT02430233	HaEmek Medical Center, Israel	Preterm Labor	December 19, 2018	Phase 4
NCT02950948	IBSA Institut Biochimique SA	Luteal Phase Defect	May 3, 2017	Phase 3
NCT03781466	Aswan University Hospital	Twin; Pregnancy, Affecting Fetus or Newborn	January 1, 2019	Not Applicable
NCT04897269	Tu Du Hospital	Assisted Reproductive Technology	May 20, 2021	Phase 3
NCT00827983	IBSA Institut Biochimique SA	In Vitro Fertilization	January 2009	Phase 3
NCT01427595	University of Virginia\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Polycystic Ovary Syndrome\|Hyperandrogenism	February 18, 2009	Not Applicable
NCT02086032	Chiang Mai University	Menopausal and Postmenopausal Disorders	January 2014	Not Applicable
NCT04534881	St. Louis University	Transgender Persons	October 20, 2020	Phase 2
NCT02092571	Teva Branded Pharmaceutical Products R&D, Inc.	Pharmacokinetics	February 2014	Phase 1
NCT01840228	Washington University School of Medicine\|Thrasher Research Fund	Premature Birth\|Obstetric Labor, Premature	May 2013	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 79.50 mM ; Need ultrasonic)

H ₂ O : 0.1 mg/mL ( 0.32 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1801 mL	15.9003 mL	31.8005 mL
5 mM	0.6360 mL	3.1801 mL	6.3601 mL
10 mM	0.3180 mL	1.5900 mL	3.1801 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 50% PEG300 >> 50% saline

Solubility: 20 mg/mL (63.60 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.61 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2003 Dec 10;46 Suppl 1:S7-S16.
[2] Zava DT, et al. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998 Mar;217(3):369-78.
[3] Komesaroff PA, et al. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001 Jun;4(2):144-50.
[4] Girling JE, et al. Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology. 2007 Nov;148(11):5433-41. Epub 2007 Aug 9.

Synonyms

Pregn-4-ene-3,20-dione

Progesterone

Corlutin

Corlutina

Corluvite

Corporin

Corpus luteum hormone

Flavolutan

Fologenon

Gestone

Gestormone

Glanducorpin

Hormoflaveine

Hormoluton

Luteal Hormone

Luteinique

Luteodyn

Luteogan

Luteohormone

Luteosan

Luteostab

Luteovis

Lutex

Lutidon

Lutocyclin

Lutocyclin M

Lutocylin

Lutoform

Lutogyl

Lutren

Lutromone

Piaponon

Primolut

Progekan

Progesterol

Progestin

Progestone

Prolidon

Luteol

Syntolutan

Proluton

Agolutin

Lucorteum Sol

Gestron

Percutacrine Luteinique

Lipo-Lutin

Nalutron

Progestron

Luteopur

Bio-luton

Gynlutin

Gynolutone

Gesterol

Luteocrin normale

Syngestrets

Prolets

Lutin

Lutociclina

Protormone

Progestasert

Vitarrine

Δ⁴-Pregnene-3,20-dione

Utrogestan

Luteum

U 3672

Crinone

Progestogel

Lugesteron

Prontogest

Prometrium

Utrogest

Cyclogest

Syngesterone

Progestol

Gestiron

Lutocuclin M

Progeston

NSC 64377

NSC 9704

Progeffik

Progestan

Duraprogen

CIDR

Estima

Prochieve

Endometrin

Minagest

Microgest

Lugesterone

EAZI-BREED CIDR

4-Pregnene-3,20-dione

Luteosterone

Sincrogest

Lutinus

Cue-Mate

Progeffik 200

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