[CAS NO. 570390-00-0] A2ti-1
PRODUCTS SPECIFICATIONS [570390-00-0]
DESCRIPTION [570390-00-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 382.48 |
| Molecular Formula | C20H22N4O2S |
| SMILES | O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3CC |
Summary
IC50 & Target
IC50: 24 μM (A2t) [1]
In Vitro
A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker
[1]
.
A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner
[2]
.
A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [2]
| Cell Line: | HeLa cells |
| Concentration: | 100 μM |
| Incubation Time: | For 72 hours |
| Result: | Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 653.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6145 mL | 13.0726 mL | 26.1452 mL |
| 5 mM | 0.5229 mL | 2.6145 mL | 5.2290 mL |
| 10 mM | 0.2615 mL | 1.3073 mL | 2.6145 mL |
References
- [1] Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.
- [2] Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90.