[CAS NO. 573-40-0] Rapanone

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PRODUCTS SPECIFICATIONS [573-40-0]

Catelog

HY-N8213

Brand

MCE

CAS

573-40-0

DESCRIPTION [573-40-0]

Overview

MDL	MFCD00075883
Molecular Weight	322.44
Molecular Formula	C19H30O4
SMILES	O=C1C(O)=C(CCCCCCCCCCCCC)C(C(O)=C1)=O

For research use only. We do not sell to patients.

Summary

Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA ₂ inhibitor, with an IC ₅₀ of 2.6 μM ^[1] ^[2] ^[3] ^[4] .

IC50 & Target

PLA2

2.6 μM (IC ₅₀ )

In Vitro

Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC ₅₀ s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively ^[1] .
Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells ^[1] .
Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 77.53 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1014 mL	15.5068 mL	31.0135 mL
5 mM	0.6203 mL	3.1014 mL	6.2027 mL
10 mM	0.3101 mL	1.5507 mL	3.1014 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.75 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-tridecyl-

p-Benzoquinone, 2,5-dihydroxy-3-tridecyl-

Rapanone

2,5-Dihydroxy-3-tridecyl-2,5-cyclohexadiene-1,4-dione

Ropanone

NSC 340285