[CAS NO. 5784-74-7] Salsolidine
PRODUCTS SPECIFICATIONS [5784-74-7]
DESCRIPTION [5784-74-7]
Overview
| MDL | MFCD00694774 |
|---|---|
| Molecular Weight | 207.27 |
| Molecular Formula | C12H17NO2 |
| SMILES | CC1NCCC2=C1C=C(OC)C(OC)=C2 |
Summary
Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.
IC50 & Target
MAO A [1]
In Vitro
Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (K
i
=6 μM and 186 μM, respectively)
[1]
.
Salsolidine weakly inhibits the binding of δ-receptor, with a K
i
of >100 μM
[2]
.
Salsolidine has the potential of inhibiting Acetylcholinestearse and butyrylcholinesterase
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
bovine liver
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 241.23 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.8246 mL | 24.1231 mL | 48.2462 mL |
| 5 mM | 0.9649 mL | 4.8246 mL | 9.6493 mL |
| 10 mM | 0.4825 mL | 2.4123 mL | 4.8246 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution
References
- [1] Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52.
- [2] Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5.
- [3] Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24.