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[CAS NO. 579-13-5] OligomycinA
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-16589 |
| Brand: | MCE |
| CAS: | 579-13-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 791.06 |
| Molecular Formula | C45H74O11 |
| SMILES | O=C(/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@@H]1C)=O)O[C@@]([C@@H]2C)([H])[C@H](C)[C@@]3(CC[C@H](C)[C@H](C[C@H](O)C)O3)O[C@@]2([H])CC[C@@H](CC)/C=C/C=C/C[C@@H](C)[C@H](O)[C@@](C)(O)C1=O |
16 Publications Citing Use of MCE
- [1]Cell Res. 2021 Sep;31(9):980-997.
- [2]Nano Today. 1 June 2022.
- [3]Nat Commun. 2022 Apr 6;13(1):1853.
- [4]Cell Mol Gastroenterol Hepatol. 2023 Jan 24;S2352-345X(23)00004-8.
- [5]Cell Rep. 2021 Sep 21;36(12):109739.
- [6]Clin Transl Med. 2021 Apr;11(4):e395.
- [7]Elife. 2022 Jun 24;11:e74713.
- [8]PLoS Biol. 2021 Apr 27;19(4):e3001197.
- [9]Oxid Med Cell Longev. 2022 Mar 18;2022:2513837.
- [10]Int J Mol Sci. 2022, 23(20), 12354.
- [11]Sci Rep. 2021 Dec 14;11(1):23977.
- [12]J Leukoc Biol. 2021 Dec 20.
- [13]Nutr Cancer. 2020;72(4):696-707.
- [14]Research Square Print. September 9th, 2022.
- [15]SSRN. 15 Sep 2021 .
- [16]Cell Physiol Biochem. 2018;48(6):2318-2336.
Summary
Oligomycin A (MCH 32), created by Streptomyces , acts as a mitochondrial F 0 F 1 -ATPase inhibitor, with a K i of 1 μM; Oligomycin A shows anti-fungal activity.
IC50 & Target
Ki: 1 μM (F 0 F 1 -ATPase) [1]
In Vitro
Oligomycin A is a mitochondrial F 0 F 1 -ATPase inhibitor with a K i of 1 μM. Oligomycin A shows cytotoxic to the NCI-60 cell lines, with GI 50 of 10 nM. Oligomycin A also inhibits the activity of Triton X-100-solubilized ATPase with a K i of 0.1 μM. Furthermore, Oligomycin A has anti-fungal activity [1] . Oligomycin A (2.4 µM) inhibits the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), and also suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) as well as the concomitant peaks of O 2 consumption and ATP levels [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Streptomyces diastatochromogenes
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 126.41 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.2641 mL | 6.3206 mL | 12.6413 mL |
| 5 mM | 0.2528 mL | 1.2641 mL | 2.5283 mL |
| 10 mM | 0.1264 mL | 0.6321 mL | 1.2641 mL |
References
- [1] Salomon AR, et al. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem Biol. 2001 Jan;8(1):71-80.
- [2] Ramió-Lluch L, et al. Oligomycin A-induced inhibition of mitochondrial ATP-synthase activity suppresses boar sperm motility and in vitro capacitation achievement without modifying overall sperm energy levels. Reprod Fertil Dev. 2014;26(6):883-97.
Synonyms
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