[CAS NO. 579-38-4] Diloxanide
PRODUCTS SPECIFICATIONS [579-38-4]
DESCRIPTION [579-38-4]
Overview
| MDL | MFCD00592507 |
|---|---|
| Molecular Weight | 234.08 |
| Molecular Formula | C9H9Cl2NO2 |
| SMILES | O=C(C(Cl)Cl)N(C)C1=CC=C(C=C1)O |
Summary
Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147) [1] .
IC50 & Target
|
Amebae |
In Vivo
Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate
[1]
.
Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 142.39 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.2720 mL | 21.3602 mL | 42.7204 mL |
| 5 mM | 0.8544 mL | 4.2720 mL | 8.5441 mL |
| 10 mM | 0.4272 mL | 2.1360 mL | 4.2720 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (10.68 mM); Clear solution
References
Synonyms