[CAS NO. 584-28-1] Aspidin BB

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PRODUCTS SPECIFICATIONS [584-28-1]

Catalog

HY-108164

Brand

MCE

CAS

584-28-1

DESCRIPTION [584-28-1]

Overview

MDL	-
Molecular Weight	460.52
Molecular Formula	C25H32O8
SMILES	CCCC(C1=C(C(C)(C)C(O)=C(CC2=C(O)C(C(CCC)=O)=C(OC)C(C)=C2O)C1=O)O)=O

For research use only. We do not sell to patients.

Summary

Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii . Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells ^[1] ^[2] .

IC50 & Target

Bcl-2

Bax

Caspase-3

In Vitro

Aspidin BB (0-100 μM, 24-72 h) significantly inhibits HO-8910 cell proliferation in a dose- and time-dependent manner. The IC ₅₀ values are 15.02, 25.79 and 68.81 μM after 72, 48 and 24 h treatment, respectively ^[1] .
Aspidin BB suppresses Bcl-2 expression and enhances Bax expression to desintegrate the outer mitochondrial membrane, then causes cytochrome c release which leads to the activation of effector caspase-3, and further cleaves the poly ADP-ribose polymerase (PARP) in the nucleus, finally induces cell apoptosis ^[1] .
Aspidin BB provokes S phase arrest in HO-8910 cells with up-regulation of pRb, E2F1, CDK2, cyclin E and cyclin A proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.