[CAS NO. 58546-34-2] Cucurbitacin IIa

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PRODUCTS SPECIFICATIONS [58546-34-2]

Catalog

HY-N1988

Brand

MCE

CAS

58546-34-2

DESCRIPTION [58546-34-2]

Overview

MDL	MFCD07781419
Molecular Weight	562.73
Molecular Formula	C32H50O8
SMILES	C[C@@]([C@@](CC=C1[C@@]2([H])C[C@H](O)[C@@H](O)C1(C)C)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(CCC(C)(C)OC(C)=O)=O)[C@@]4(C3)C

For research use only. We do not sell to patients.

Summary

Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin , reduces phospho-Histone H3 and increases cleaved PARP in cancer cells ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 44.43 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7771 mL	8.8853 mL	17.7705 mL
5 mM	0.3554 mL	1.7771 mL	3.5541 mL
10 mM	0.1777 mL	0.8885 mL	1.7771 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Boykin C, et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer. 2011 Mar 1;104(5):781-9.

Synonyms

19-Norlanost-5-ene-11,22-dione, 25-(acetyloxy)-2,3,16,20-tetrahydroxy-9-methyl-, (2β,3α,9β,10α,16α)-

(2β,3α,9β,10α,16α)-25-(Acetyloxy)-2,3,16,20-tetrahydroxy-9-methyl-19-norlanost-5-ene-11,22-dione

Cucurbitacin II_a

Dihydrocucurbitacin F 25-O-acetate

25-Acetoxy-23,24-dihydrocucurbitacin F

25-O-Acetyl-23,24-dihydrocucurbitacin F

Dihydrocucurbitacin Q1

23,24-Dihydrocucurbitacin F-25-O-acetate

Hemslecin A

23,24-Dihydrocucurbitacin F 25-acetate