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[CAS NO. 58880-19-6] TrichostatinA

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Catalog:	HY-15144
Brand:	MCE
CAS:	58880-19-6

Overview

MDL	MFCD03848392
Molecular Weight	302.37
Molecular Formula	C17H22N2O3
SMILES	CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C

For research use only. We do not sell to patients.

77 Publications Citing Use of MCE

[1]Cell Metab. 2021 May 4;33(5):988-1000.e7.
[2]Nat Immunol. 2023 Jan;24(1):162-173.
[3]Nat Biomed Eng. 2018 Aug;2(8):578-588.
[4]Circ Res. 2022 Aug 19;131(5):456-472.
[5]Nat Commun. 2022 Oct 26;13(1):6350.
[6]Nat Commun. 2022 May 13;13(1):2672.
[7]Nat Commun. 2021 Sep 20;12(1):5548.
[8]Nat Commun. 2021 Jul 9;12(1):4227.
[9]Nat Commun. 2021 Feb 23;12(1):1237.
[10]Nucleic Acids Res. 2020 May 21;48(9):4858-4876.
[11]Cancer Res. 2021 Jan 25;canres.2808.2020.
[12]Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9967-76.
[13]Kidney Int. 2017 Sep;92(3):669-679.
[14]ACS Appl Mater Interfaces. 2022 Aug 1.
[15]Theranostics. 2019 Apr 13;9(9):2424-2438.
[16]Oncogene. 2020 Mar;39(11):2437-2449.
[17]Cancer Lett. 2022 Nov 30;216028.
[18]Cancer Lett. 2021 Jul 30;S0304-3835(21)00382-7.
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Summary

Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II , with an IC ₅₀ value of 1.8 nM for HDAC ^[1] .

IC50 & Target

HDAC

1.8 nM (IC ₅₀ )

In Vitro

Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC ₅₀ value of 1.8 nM for HDAC. Trichostatin A (TSA) inhibits proliferation of eight breast carcinoma cell lines with mean±SD IC ₅₀ of 124.4±120.4 nM (range, 26.4-308.1 nM). HDAC inhibitory activity of Trichostatin A is similar in all cell lines with mean IC ₅₀ of 2.4±0.5 nM (range, 1.5-2.9 nM) ^[1] . Trichostatin A (330 nM) increases Gαs protein expression in human myometrial cells, but does not increase Gαs mRNA levels ^[2] . Trichostatin A (20-75 nM) induces minimal cytotoxicity to adipose-derived stem cells (ADSCs), and enhances the osteogenic differentiation capacity of ADSCs ^[3] . In addition, Trichostatin A (0, 10, 100, 500 nM) dose-dependently decreases HDAC class I/II activity ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trichostatin A (500 μg/kg, s.c.) pronounces antitumor activity without causing any measurable toxicity in doses of up to 5 mg/kg by s.c. injection, in randomized controlled efficacy studies using the N-methyl-N-nitrosourea carcinogen-induced rat mammary carcinoma model ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 82.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3072 mL	16.5360 mL	33.0721 mL
5 mM	0.6614 mL	3.3072 mL	6.6144 mL
10 mM	0.3307 mL	1.6536 mL	3.3072 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (8.27 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution
3.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: 2.5 mg/mL (8.27 mM); Suspended solution; Need ultrasonic
4.

Add each solvent one by one: 5% DMSO >> 95% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001 Apr;7(4):971-6.
[2] Karolczak-Bayatti M, et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A.,Reprod Sci. 2012 Aug 8.
[3] Hu X, et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner.,Stem Cells Dev. 2012 Aug 8.
[4] Azechi T, et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20(6):538-47.

Synonyms

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [R-(E,E)]-

(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Trichostatin A

(R)-Trichostatin A

TSA

(R)-(+)-Trichostatin A

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