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[CAS NO. 59-49-4] 2-Benzoxazolinone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W015818 |
| Brand: | MCE |
| CAS: | 59-49-4 |
Overview
| MDL | MFCD00005716 |
|---|---|
| Molecular Weight | 135.12 |
| Molecular Formula | C7H5NO2 |
| SMILES | O=C1OC2=CC=CC=C2N1 |
1 Publications Citing Use of MCE
Summary
2-Benzoxazolinone is an anti-leishmanial agent with an LC 50 of 40 μg/mL against L. donovani [1] . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts [3] . Derivatives as anti-quorum sensing agent [4] .
IC50 & Target
LC50: 40 μg/mL (L. donovani) [1]
In Vitro
2-Benzoxazolinone (0.1-5 mM) induces oxidative stress in mung bean through generation of ROS and upregulation of activities of various scavenging enzymes [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 740.08 mM ; Need ultrasonic)
H 2 O : 3.85 mg/mL ( 28.49 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 7.4008 mL | 37.0041 mL | 74.0083 mL |
| 5 mM | 1.4802 mL | 7.4008 mL | 14.8017 mL |
| 10 mM | 0.7401 mL | 3.7004 mL | 7.4008 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 5 mg/mL (37.00 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (18.50 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (18.50 mM); Clear solution
References
- [1] Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8.
- [2] Batish DR, et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus). Plant Physiology and Biochemistry 44(11-12):819-27
- [3] Krawiecka M, et al. Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives. Acta Pol Pharm. 2013 Mar-Apr;70(2):245-53.
- [4] Miandji AM, et al. Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents. Arzneimittelforschung. 2012 Jul;62(7):330-4.
Synonyms
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