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[CAS NO. 60-99-1] Levomepromazine

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Catalog:	HY-B1693
Brand:	MCE
CAS:	60-99-1

Overview

MDL	-
Molecular Weight	328.47
Molecular Formula	C19H24N2OS
SMILES	COC1=CC=C2SC3=C(N(C2=C1)C[C@@H](CN(C)C)C)C=CC=C3

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Br J Pharmacol. 2022 Jul;179(14):3675-3692.

Summary

Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors ^[1] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02374567	Hannover Medical School	Dementia\|Depression\|Schizophrenia\|Psychosomatic Disorders\|Anxiety Disorders	January 2015	Phase 3

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL ( 126.86 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0444 mL	15.2221 mL	30.4442 mL
5 mM	0.6089 mL	3.0444 mL	6.0888 mL
10 mM	0.3044 mL	1.5222 mL	3.0444 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.43 mg/mL (4.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.43 mg/mL (4.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.43 mg/mL (4.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015 Nov 2;(11):CD009420.
[2] Sivaraman P, et al. Levomepromazine for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007779.

Synonyms

10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (βR)-

Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-, (-)-

10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (R)-

(βR)-2-Methoxy-N,N,β-trimethyl-10H-phenothiazine-10-propanamine

Levomepromazine

Levopromazine

Levoprome

Levopromethazine

Nozinan

Sinogan

Mepromazine

Levomepromazin

Methotrimeprazine

Nozinane

SKF 5116

7044 R.P.

2-Methoxytrimeprazine

Levomeprazine

Sinogan-Debil

Nirvan

Tisercin

Neozine

RP 7044

CL 36467

CL 39743

Hirnamin

Levotomin

XP 03

NSC 226516

(2R)-3-(2-Methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine

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