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Catalog: | HY-12884 |
Brand: | MCE |
CAS: | 6019-39-2 |
MDL | MFCD03055811 |
---|---|
Molecular Weight | 236.27 |
Molecular Formula | C15H12N2O |
SMILES | O=C(NC1=CC2=C(NC=C2)C=C1)C3=CC=CC=C3 |
OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.
Octamer-binding transcription factor 4 (Oct4) is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of differentiation. It is the only factor that cannot be substituted by other members of the same protein family to induce pluripotency [1] . Oct4 has been shown to be an essential regulator of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. OAC2 is a structural analog of OAC1. OAC2 activates both Oct4 and Nanog reporters to a similar extent as OAC1. OAC1 and its two structural analogs OAC2 and OAC3 enhances reprogramming efficiency fourfold, up to as high as 2.75%, and accelerates the appearance of iPSC colonies 3 to 4 d when used in combination with the four reprogramming factors, Oct4, Sox2, Klf4, and c-Myc [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : ≥ 100 mg/mL ( 423.24 mM )
Ethanol : 25 mg/mL ( 105.81 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
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1 mM | 4.2324 mL | 21.1622 mL | 42.3245 mL |
5 mM | 0.8465 mL | 4.2324 mL | 8.4649 mL |
10 mM | 0.4232 mL | 2.1162 mL | 4.2324 mL |
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (10.58 mM); Suspended solution; Need ultrasonic
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution
Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (10.58 mM); Suspended solution; Need ultrasonic
Add each solvent one by one: 10% EtOH >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution
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