[CAS NO. 60314-89-8]  Geissoschizine methyl ether

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PRODUCTS SPECIFICATIONS [60314-89-8]

Catalog
HY-N2411
Brand
MCE
CAS
60314-89-8

DESCRIPTION [60314-89-8]

Overview

MDLMFCD30725476
Molecular Weight366.45
Molecular FormulaC22H26N2O3
SMILESCOC(/C([C@H]1C[C@@]2([H])C3=C(CCN2C/C1=C/C)C4=CC=CC=C4N3)=C\OC)=O

For research use only. We do not sell to patients.

Summary

Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT 1A receptor agonist [1] [2] .


IC50 & Target

5-HT 1A Receptor


Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 272.89 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7289 mL 13.6444 mL 27.2889 mL
5 mM 0.5458 mL 2.7289 mL 5.4578 mL
10 mM 0.2729 mL 1.3644 mL 2.7289 mL
* Please refer to the solubility information to select the appropriate solvent.


Synonyms

Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αZ,2S,3E,12bS)-
Corynan-16-carboxylic acid, 16,17,19,20-tetradehydro-17-methoxy-, methyl ester, (16Z,19E)-
Geissoschizine methyl ether
Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, [2S-[2α(Z),3E,12bβ]]-
O-Methyl-16Z-geissoschizine