[CAS NO. 60755-80-8] O-DesmethylGalanthamine

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PRODUCTS SPECIFICATIONS [60755-80-8]

Catalog

HY-131413

Brand

MCE

CAS

60755-80-8

DESCRIPTION [60755-80-8]

Overview

MDL	-
Molecular Weight	273.33
Molecular Formula	C16H19NO3
SMILES	OC1=CC=C2C3=C1O[C@@]4([H])C[C@@H](O)C=C[C@@]34CCN(C)C2

For research use only. We do not sell to patients.

Summary

O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC ₅₀ 1.83 μM ^[1] .

IC50 & Target

AChE ^[1]

Appearance

Powder

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 365.86 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6586 mL	18.2929 mL	36.5858 mL
5 mM	0.7317 mL	3.6586 mL	7.3172 mL
10 mM	0.3659 mL	1.8293 mL	3.6586 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.15 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.15 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.15 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Seydou Ka, et al. Gigantelline, gigantellinine and gigancrinine, cherylline- and crinine-type alkaloids isolated from Crinum jagus with anti-acetylcholinesterase activity. Phytochemistry. 2020 Jul;175:112390.

Synonyms

6H-Benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol, 4a,5,9,10,11,12-hexahydro-11-methyl-, (4aS,6R,8aS)-

Galanthamine, O-demethyl-

(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol

6H-Benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol, 4a,5,9,10,11,12-hexahydro-11-methyl-, [4aS-(4aα,6β,8aR*)]-

O-Demethylgalanthamine

Sanguinine