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[CAS NO. 6119-47-7] Quininehydrochloridedihydrate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B0433A |
| Brand: | MCE |
| CAS: | 6119-47-7 |
Overview
| MDL | MFCD00151248 |
|---|---|
| Molecular Weight | 396.91 |
| Molecular Formula | C20H29ClN2O4 |
| SMILES | COC1=CC2=C(N=CC=C2[C@H]([C@@]3([H])[N@](C[C@@H]4C=C)CC[C@@]4([H])C3)O)C=C1.Cl.O.O |
2 Publications Citing Use of MCE
Summary
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K Ca 5.1) channel currents evoked by voltage pulses to +100 mV with an IC 50 of 169 μM [1] [2] .
In Vitro
Quinine hydrochloride dihydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line
[1]
.
Quinine hydrochloride dihydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | Human hepatocarcinoma cell line(HepG2) |
| Concentration: | 150 μM |
| Incubation Time: | 30 min |
| Result: | Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner. |
In Vivo
Quinine hydrochloride dihydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice
[2]
.
Quinine hydrochloride dihydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Swiss albino mice 7-8-weeks (weighing 24 g) [2] |
| Dosage: | Swiss albino mice 7-8-weeks (weighing 24 g) [2] |
| Administration: | Oral gavage; every week; 16 weeks |
| Result: | Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02630472 | University of Pennsylvania |
Rhinitis|Sinusitis
|
October 2015 | Phase 1|Phase 2 |
| NCT00785213 | Mutual Pharmaceutical Company, Inc.|Cetero Research, San Antonio |
Healthy
|
September 2008 | Phase 1 |
| NCT00785551 | Mutual Pharmaceutical Company, Inc. |
Healthy|Renal Impairment
|
November 2007 | Phase 1 |
| NCT00727272 | Mutual Pharmaceutical Company, Inc. |
Healthy
|
February 2004 | Phase 1 |
| NCT00726895 | Mutual Pharmaceutical Company, Inc. |
Healthy
|
May 2004 | Phase 1 |
| NCT00806078 | Mutual Pharmaceutical Company, Inc. |
Healthy
|
July 2007 | Phase 1 |
| NCT00000706 | National Institute of Allergy and Infectious Diseases (NIAID) |
HIV Infections
|
Not Applicable | |
| NCT00785486 | Mutual Pharmaceutical Company, Inc. |
Healthy
|
March 2007 | Phase 1 |
| NCT00785980 | Mutual Pharmaceutical Company, Inc. |
Healthy
|
September 2008 | Phase 1 |
| NCT00726414 | Mutual Pharmaceutical Company, Inc. |
Healthy
|
December 2005 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 251.95 mM )
H 2 O : 20 mg/mL ( 50.39 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5195 mL | 12.5973 mL | 25.1946 mL |
| 5 mM | 0.5039 mL | 2.5195 mL | 5.0389 mL |
| 10 mM | 0.2519 mL | 1.2597 mL | 2.5195 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 2.6 mg/mL (6.55 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.
- [2] Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.
- [3] Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-
- [4] White, N.J., et al., Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med, 1982. 73(4): p. 564-72.
Synonyms
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