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[CAS NO. 61281-38-7] Schisandrin A
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-N0693 |
| Brand: | MCE |
| CAS: | 61281-38-7 |
Overview
| MDL | MFCD09026934 |
|---|---|
| Molecular Weight | 416.51 |
| Molecular Formula | C24H32O6 |
| SMILES | C[C@H]1CC2=CC(OC)=C(OC)C(OC)=C2C3=C(OC)C(OC)=C(OC)C=C3C[C@H]1C |
6 Publications Citing Use of MCE
Summary
Schisandrin A inhibits CYP3A activity with an IC 50 of 6.60 μM and K i of 5.83 μM, respectively.
IC50 & Target
|
CYP3A 6.6 μM (IC 50 ) |
Autophagy
|
In Vitro
Schisandrin A (Sch A) strongly inhibits microsomal midazolam 1-hydroxylation catalyzed by CYP3A, with an IC 50 of 6.60 μM. The recovery of enzyme activity in the absence or presence of Schisandrin A is shown in dilution assay plots. The K i value for Schisandrin A is obtained from the Dixon plots and is 5.83 μM. The inactivation of rat liver microsomal midazolam 1-hydroxylation activity by Schisandrin A in the presence of NADPH is found to be time- and concentration-dependent. The K inact and K i are estimated to be 0.134/min and 4.51 μM, respectively for Schisandrin A [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and V max value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent K i value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 120.05 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4009 mL | 12.0045 mL | 24.0090 mL |
| 5 mM | 0.4802 mL | 2.4009 mL | 4.8018 mL |
| 10 mM | 0.2401 mL | 1.2005 mL | 2.4009 mL |
References
Synonyms
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