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[CAS NO. 61301-33-5] Schisandrin C
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-N0690 |
| Brand: | MCE |
| CAS: | 61301-33-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 384.42 |
| Molecular Formula | C22H24O6 |
| SMILES | [H][C@@]([C@](C)([H])C1)(C)CC2=CC3=C(C(OC)=C2C4=C1C=C5OCOC5=C4OC)OCO3 |
2 Publications Citing Use of MCE
Summary
Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis [1] . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer , alzheimer’s disease, and liver diseases research [2] [3] . Schisandrin C induces cell apoptosis [1] .
In Vitro
Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells
[2]
.
Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells
[1]
.
Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Decreased the expression of apoptosis related proteins. |
Apoptosis Analysis [1]
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced cell apoptosis. |
Cell Cycle Analysis [1]
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced growth inhibition and G1 arrest of U937 cells. |
In Vivo
Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Aβ1-42-induced Alzheimer’s disease mice [3] |
| Dosage: | 15-150 μg/kg |
| Administration: | Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days |
| Result: | Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 8.33 mg/mL ( 21.67 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6013 mL | 13.0066 mL | 26.0132 mL |
| 5 mM | 0.5203 mL | 2.6013 mL | 5.2026 mL |
| 10 mM | 0.2601 mL | 1.3007 mL | 2.6013 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 0.83 mg/mL (2.16 mM); Clear solution
References
- [1] Park C, et al. Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells. Int J Mol Med. 2009 Oct;24(4):495-502.
- [2] Oh SY, et al. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem. 2010;74(2):285-91.
- [3] Xin Mao, et al.Schisandrin C Ameliorates Learning and Memory Deficits by Aβ 1-42 -induced Oxidative Stress and Neurotoxicity in Mice. Phytother Res. 2015 Sep;29(9):1373-1380.
- [4] Uehara T, et, al. Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat Chem Biol. 2017 Jun;13(6):675-680.
Synonyms
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