[CAS NO. 615258-40-7] Denosumab

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PRODUCTS SPECIFICATIONS [615258-40-7]

Catalog

HY-P9958

Brand

MCE

CAS

615258-40-7

DESCRIPTION [615258-40-7]

Overview

MDL	-
Molecular Weight	144716.86
Molecular Formula	C6404H9908N1724O2004S50
SMILES	[Denosumab]

For research use only. We do not sell to patients.

Summary

Denosumab is a human monoclonal antibody binding to, and inhibiting, the receptor activator of RANKL (TNFSF11). Denosumab can reduce the risk of vertebral, nonvertebral and hip fractures ^[1] , also has anti-cancer activity ^[2] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02682693	German Breast Group\|Amgen\|Celgene Corporation	Breast Cancer Female NOS\|Tubular Breast Cancer Stage II\|Mucinous Breast Cancer Stage II\|Invasive Ductal Breast Cancer\|HER2 Positive Breast Cancer\|Inflammatory Breast Cancer\|Tubular Breast Cancer Stage III	February 13, 2017	Phase 2
NCT03958565	University of Colorado, Denver	Carcinoma, Non-Small-Cell Lung	April 15, 2019
NCT02753283	Susan L. Greenspan\|National Institutes of Health (NIH)\|National Institute on Aging (NIA)\|University of Pittsburgh	Osteoporosis, Postmenopausal\|Osteoporosis\|Osteoporotic Fractures	June 2016	Phase 4
NCT04034199	Kwong Wah Hospital\|Tung Wah Group of Hospitals	Idiopathic Inflammatory Myopathies\|Osteoporosis, Osteopenia	August 15, 2019	Phase 3
NCT05402865	Shanghai JMT-Bio Inc.	Giant Cell Tumor of Bone	November 10, 2021
NCT04664959	Samsung Bioepis Co., Ltd.	Postmenopausal Osteoporosis	November 26, 2020	Phase 3
NCT01920568	GlaxoSmithKline\|Amgen	Fractures, Bone	August 2013	Phase 3
NCT05203588	Shanghai Changzheng Hospital	Osteoporosis\|Fusion of Spine, Lumbar Region	October 9, 2021	Phase 4
NCT00936897	Amgen	Postmenopausal Osteoporosis	July 2009	Phase 3
NCT01951586	Amgen	Non-Small Cell Lung Cancer	December 31, 2013	Phase 2
NCT01545648	Hope Rugo, MD\|University of California, San Francisco\|Amgen	Early Stage Breast Cancer	November 1, 2012	Phase 2
NCT01799798	University of Cologne	Osteogenesis Imperfecta	February 2013	Phase 2
NCT01630941	Hans Mallmin\|Uppsala University Hospital	Osteoarthritis, Hip\|Ambulation Difficulty	August 7, 2012	Phase 2
NCT00838201	Amgen	Cancer\|Carcinoma\|Castrate-Resistant Prostate Cancer\|Prostate Cancer\|Tumors	February 1, 2009	Phase 3
NCT00523341	Amgen	Osteopenia\|Osteoporosis	August 7, 2007	Phase 3
NCT05091086	National Taiwan University Hospital	Osteoporosis\|Bone Mineral Density	November 20, 2021	Phase 4
NCT03408652	Centre Leon Berard	Metastatic Renal Cell Carcinoma	March 15, 2019	Phase 3
NCT00980174	Amgen	Low Bone Mass\|Low Bone Mineral Density\|Males With Osteoporosis\|Osteopenia\|Osteoporosis	October 1, 2009	Phase 3
NCT03280667	Australian and New Zealand Urogenital and Prostate Cancer Trials Group\|Merck Sharp & Dohme LLC\|Amgen	Renal Cell Carcinoma, Clear Cell\|Metastatic Kidney Cancer	December 12, 2017	Phase 2
NCT01750086	Massachusetts General Hospital	Postmenopausal Osteoporosis	January 2013	Phase 4
NCT05598606	Shenzhen People´s Hospital	Denosumab Allergy\|Zoledronic Acid Allergy	January 12, 2021	Phase 4
NCT04907851	Redx Pharma Plc	Advanced Solid Tumours	December 10, 2021	Phase 2
NCT01952054	M.D. Anderson Cancer Center\|Amgen	Breast Cancer	February 9, 2015	Phase 2
NCT04467983	Felicia Cosman, MD\|Crozer-Keystone Health System\|Radius Health, Inc.\|Osteoporosis Center of Delaware County	Osteoporosis, Postmenopausal	February 1, 2021	Phase 4
NCT01575873	Amgen	Steroid-induced Osteopor, Glucocorticoid-induced Ostepor	March 28, 2012	Phase 3
NCT01558115	Columbia University\|National Institutes of Health (NIH)\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|Amgen	Primary Hyperparathyroidism	January 2012	Phase 4
NCT00680992	Amgen	Cancer\|Giant Cell Tumors\|Giant Cell Tumor of Bone\|Benign Giant Cell Tumors	September 9, 2008	Phase 2
NCT01572545	Aristotle University Of Thessaloniki\|424 General Military Hospital\|251 Hellenic Air Force & VA General Hospital	Postmenopausal Osteoporosis	April 2012	Not Applicable
NCT00089791	Amgen	Osteoporosis	August 1, 2004	Phase 3
NCT00259740	Amgen	Relapsed or Plateau-Phase Multiple Myeloma	November 2005	Phase 2
NCT01358669	Sheffield Teaching Hospitals NHS Foundation Trust\|Amgen\|University of Sheffield	Revision Surgery of Total Hip Arthroplasty	December 14, 2011	Phase 2
NCT02792413	University Hospital, Montpellier	Female With Osteoporosis and Chronic Kidney Disease	November 19, 2018	Phase 4
NCT03164928	Amgen	Evaluate the Safety and Efficacy of Denosumab in Pediatric Subjects With\|Glucocorticoid-induced Osteoporosis	May 7, 2018	Phase 3
NCT00095498	Amgen	Rheumatoid Arthritis	August 11, 2004	Phase 2
NCT03868033	National Taiwan University Hospital	Osteoporosis	April 12, 2019	Phase 4
NCT03358212	Peking University People´s Hospital	Giant Cell Tumor of Bone	March 1, 2018
NCT00043186	Amgen	Low Bone Mineral Density	May 2002	Phase 2
NCT01824342	Amgen	Castrate-resistant Prostate Cancer	January 2011	Phase 3
NCT01983475	James J. Peters Veterans Affairs Medical Center\|Kessler Institute for Rehabilitation	Osteoporosis\|Spinal Cord Injury	January 2015	Phase 4
NCT02014467	GlaxoSmithKline	Osteoporosis, Postmenopausal	January 2014	Phase 3
NCT01734824	Medical University of Vienna	Bone Marrow Oedema Syndrome\|High Turnover Bone Disease\|Quality of Life	May 2012	Phase 4
NCT03923842	Gruppo Oncologico del Nord-Ovest\|Mario Negri Institute for Pharmacological Research	Nasopharyngeal Carcinoma\|EBV Related Carcinoma	June 30, 2019	Phase 2
NCT03382574	National Cancer Institute (NCI)	Ovarian Carcinoma	March 14, 2019	Early Phase 1
NCT00321464	Amgen\|Daiichi Sankyo, Inc.	Bone Metastases	April 1, 2006	Phase 3
NCT02444585	University of Southern California\|Orthopaedic Institute for Children	Arthroplasty, Replacement, Hip	February 28, 2017	Phase 1
NCT02099461	Amgen	Healthy Volunteer, Female, Breast	April 2014	Phase 1
NCT05395091	Alvotech Swiss AG	Osteoporosis, Postmenopausal	August 23, 2022	Phase 3
NCT00091832	Amgen	Breast Cancer\|Metastases\|Bone Metastases in Subjects With Advanced Breast Cancer	September 2004	Phase 2
NCT04241211	Seoul National University Bundang Hospital	Spine Deformity	January 1, 2014	Phase 4
NCT05106517	Shenzhen People´s Hospital	Denosumab vs Zoledronate	September 8, 2021	Phase 2\|Phase 3
NCT00896454	Amgen	Breast Cancer\|Hypercalcemia of Malignancy\|Colon Cancer\|Endocrine Cancer\|Head and Neck Cancer\|Kidney Cancer\|Lung Cancer\|Lymphoma\|Metastatic Cancer\|Multiple Myeloma\|Parathyroid Neoplasms\|Renal Cancer\|Thyroid Cancer\|Hodgkin´s Lymphoma\|Non-Hodgkin´s Lymphoma\|Non-Small Cell Lung Cancer	November 16, 2009	Phase 2
NCT02135640	GlaxoSmithKline	Osteoporosis	July 17, 2014	Phase 1
NCT05278338	Shanghai JMT-Bio Inc.	Postmenopausal Osteoporosis	April 21, 2022	Phase 2
NCT02051218	Swiss Group for Clinical Cancer Research	Metastatic Breast Cancer\|Metastatic Prostate Cancer\|Bone Metastases	July 16, 2014	Phase 3
NCT03457818	Mishaela Rubin\|Columbia University	Diabetes Mellitus, Type 2\|Osteoporosis	November 7, 2018	Phase 2
NCT02833610	Massachusetts General Hospital\|Amgen\|Emory University\|University of Rochester\|University Hospitals Cleveland Medical Center	Multiple Myeloma	August 2016	Phase 2
NCT03839459	University of Rochester\|Amgen	Smoldering Multiple Myeloma	April 19, 2019	Phase 2
NCT01864798	Jules Bordet Institute\|Melbourne Health	Breast Neoplasms	July 2013	Phase 2
NCT03027557	Peter Vestergaard\|Aalborg University\|Aalborg University Hospital	Primary Hyperparathyroidism\|Parathyroid Adenoma\|Parathyroid Hyperplasia	March 1, 2017	Phase 3
NCT01464931	Amgen	Renal Impairment	November 2011	Phase 1
NCT03070002	Northwestern University\|Amgen\|National Cancer Institute (NCI)	Breast Carcinoma Metastatic in the Bone\|Circulating Tumor Cell Count\|Estrogen Receptor Positive\|HER2+Neu Negative\|Progesterone Receptor Positive\|Stage IV Breast Cancer	October 19, 2017	Phase 2
NCT05058443	Shenzhen People´s Hospital	Osteoporotic Vertebral Compression Fracture	January 6, 2020	Phase 2\|Phase 3
NCT03623633	Massachusetts General Hospital	Osteoporosis, Postmenopausal\|Osteoporosis	November 30, 2018	Phase 4
NCT05419050	National Institute of Dental and Craniofacial Research (NIDCR)\|National Institutes of Health Clinical Center (CC)	Fibrous Dysplasia	October 12, 2022	Phase 2
NCT03270020	Hellenic Society for the Study of Bone Metabolism	Langerhans Cell Histiocytosis	September 7, 2017	Phase 2
NCT00896532	Amgen	Low Bone Mineral Density\|Postmenopausal Osteoporosis	June 3, 2009	Phase 2
NCT03415477	Peking University People´s Hospital	Bone Cyst Aneurysmal\|Pathological Fracture\|Recurrent Disease\|Refractory Tumor	January 1, 2014	Phase 1\|Phase 2
NCT04232657	VA Office of Research and Development\|Kessler Institute for Rehabilitation	Spinal Cord Injury (=3 Years)\|Sublesional Bone Loss Secondary to SCI	October 28, 2020	Phase 2
NCT03822078	Amgen	Osteoporosis	September 30, 2003	Phase 1
NCT04085419	University Medical Centre Ljubljana	Primary Hyperparathyroidism\|Osteoporosis	May 8, 2019	Phase 4
NCT00293813	Amgen	Postmenopausal Osteoporosis	May 2006	Phase 2
NCT02352753	Amgen	Osteogenesis Imperfecta	June 24, 2015	Phase 3
NCT02900469	NYU Langone Health	Breast Cancer	October 2016	Early Phase 1
NCT03401060	Assistance Publique - Hôpitaux de Paris\|CEREMAST	Osteoporosis\|Systemic Mastocytosis	March 5, 2018	Phase 3
NCT02299817	Olof Skoldenberg\|Danderyd Hospital	Osteolysis	August 2015	Phase 2
NCT00286091	Amgen	Hormone Refractory Prostate Cancer	January 24, 2006	Phase 3
NCT04231682	Albert Einstein Healthcare Network\|Amgen	Osteoporosis	July 1, 2020	Phase 2
NCT01377467	Rudolf Wuethrich\|University of Zurich	Osteoporosis\|Chronic Kidney Disease	June 2011	Phase 3
NCT00680953	Daiichi Sankyo Co., Ltd.\|Daiichi Sankyo, Inc.	Osteoporosis	May 2008	Phase 3
NCT02559648	Ersi Voskaridou\|Laikο General Hospital, Athens	Thalassemia Major\|Osteoporosis	September 2014	Phase 2
NCT00396279	Amgen	GCT\|Giant Cell Tumor of Bone	July 10, 2006	Phase 2
NCT02053753	Amgen	Healthy Volunteer	February 2014	Phase 1
NCT05126784	Alvotech Swiss AG	Healthy Male Subjects	June 29, 2022	Not Applicable
NCT05493761	Aristotle University Of Thessaloniki\|424 General Military Hospital	Nonalcoholic Fatty Liver\|Osteoporosis, Postmenopausal	September 2022	Phase 4
NCT02613416	Alison Stopeck\|Amgen\|Stony Brook University	Breast Cancer	November 2015	Phase 2
NCT02721433	Ottawa Hospital Research Institute	Breast Cancer\|Prostate Cancer\|Metastasis	August 2016	Phase 4
NCT04702204	Nigde Omer Halisdemir University	Postmenopausal Osteoporosis	July 1, 2020
NCT02520362	Amgen\|Aarhus University Hospital\|Optum, Inc.\|University of Alabama at Birmingham	Osteoporosis	May 31, 2010
NCT01652690	Amgen\|One Amgen Center Drive\|THOUSAND OAKS\|CA\|91320-1799\|USA	Osteoporosis, Postmenopausal	June 26, 2012
NCT01345019	Amgen\|Daiichi Sankyo, Inc.	Cancer\|Hematologic Malignancies\|Multiple Myeloma\|Oncology\|Bone Metastases\|Multiple Myeloma Bone Lesions	May 17, 2012	Phase 3
NCT00925600	Amgen	Cancer\|Cataract\|Low Bone Mineral Density\|Osteopenia\|Osteoporosis\|Prostate Cancer	November 30, 2009	Phase 3
NCT02554695	Mayo Clinic	Bone Loss\|Aging	October 20, 2015	Early Phase 1
NCT01978483	Innovaderm Research Inc.	Ultraviolet Rays\|Immunosuppression\|Hypersensitivity, Delayed\|Immune Tolerance+Drug Effects	November 2013	Phase 1
NCT03301857	Amgen	Giant Cell Tumor of Bone	November 13, 2017	Phase 4
NCT00890981	Amgen	Low Bone Mass\|Low Bone Mineral Density\|Osteoporosis\|Postmenopausal Osteoporosis	July 2009	Phase 3
NCT02677246	St. Justine´s Hospital	Disorder Related to Bone Marrow Transplantation	December 2016	Phase 1
NCT03040765	Hamad Medical Corporation	Thalassemia Majors (Beta-Thalassemia Major)\|Osteoporosis	May 14, 2018	Phase 3
NCT00926380	Massachusetts General Hospital\|Amgen	Osteoporosis	June 2009	Phase 2
NCT03792763	Arbeitsgemeinschaft medikamentoese Tumortherapie\|Amgen\|Assign Data Management and Biostatistics GmbH	Multiple Myeloma	September 30, 2019	Phase 2
NCT05212337	Martin Blomberg Jensen\|Rigshospitalet, Denmark	Infertility, Male	January 1, 2022	Phase 2
NCT01495000	GlaxoSmithKline	Osteoporosis, Postmenopausal	January 2012	Phase 3
NCT03732495	Centre Leon Berard	Thyroid Cancer Metastatic	July 26, 2019	Phase 2
NCT02499237	424 General Military Hospital\|251 Hellenic Air Force & VA General Hospital\|Leiden University Medical Center	Postmenopausal Osteoporosis	July 2015	Phase 4
NCT05435768	Second Affiliated Hospital of Soochow University	Metastatic Solid Tumor	August 16, 2022
NCT00556374	Amgen\|Austrian Breast and Colorectal Cancer Study Group	Breast Cancer	December 18, 2006	Phase 3
NCT03638128	Amgen	Osteogenesis Imperfecta (OI)	July 26, 2018	Phase 3
NCT02422108	Martin Blomberg Jensen\|Rigshospitalet, Denmark	Testis\|Infertility\|Sperm	May 2015	Phase 2
NCT02470091	Children´s Oncology Group\|National Cancer Institute (NCI)	Metastatic Osteosarcoma\|Recurrent Osteosarcoma\|Refractory Osteosarcoma\|Stage IV Osteosarcoma AJCC v7\|Stage IVA Osteosarcoma AJCC v7\|Stage IVB Osteosarcoma AJCC v7	November 9, 2015	Phase 2
NCT01077154	Amgen\|Daiichi Sankyo, Inc.	Breast Cancer	June 2, 2010	Phase 3
NCT03029442	James J. Peters Veterans Affairs Medical Center\|Kessler Institute for Rehabilitation	Secondary Osteoporosis\|Spinal Cord Injury	April 1, 2017	Phase 4
NCT04907539	Redx Pharma Plc	Colorectal Cancer	November 8, 2021	Phase 2
NCT03620019	UNC Lineberger Comprehensive Cancer Center\|Amgen	Melanoma Stage Iii\|Melanoma Stage Iv\|Melanoma\|Melanoma (Skin)\|Cutaneous Melanoma	September 25, 2018	Phase 2
NCT01753856	Eli Lilly and Company	Osteoporosis	January 2013	Phase 4
NCT05101018	James J. Peters Veterans Affairs Medical Center\|Kessler Institute for Rehabilitation	Osteoporosis\|Spinal Cord Injuries	November 1, 2021	Phase 4
NCT01624766	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Advanced Malignant Neoplasm\|Metastatic Malignant Neoplasm\|Recurrent Malignant Neoplasm\|Refractory Malignant Neoplasm	June 19, 2012	Phase 1
NCT05010590	Massachusetts General Hospital	Postmenopausal Osteoporosis	March 24, 2022	Phase 4
NCT03620149	European Organisation for Research and Treatment of Cancer - EORTC\|Amgen	Bone Giant Cell Tumor	September 26, 2019	Phase 2
NCT03293108	AryoGen Pharmed Co.	Osteoporosis	April 29, 2017	Phase 3
NCT03030196	Martin Blomberg Jensen\|Rigshospitalet, Denmark	Infertility, Male	January 2017	Phase 2
NCT03691311	Institut Català d´Oncologia\|Amgen	Breast Neoplasm Female\|Stage I Breast Cancer\|Stage II Breast Cancer\|Hormone Receptor Negative Neoplasm\|Hormone Receptor Positive Tumor	July 5, 2018	Early Phase 1
NCT03571191	National Institute of Dental and Craniofacial Research (NIDCR)\|National Institutes of Health Clinical Center (CC)	Bone Diseases\|Pain	June 13, 2019	Phase 2
NCT02132026	University of Edinburgh\|British Heart Foundation\|NHS Lothian	Calcific Aortic Stenosis	November 12, 2014	Phase 2
NCT02157948	Amgen	Postmenopausal Osteoporosis	May 2014	Phase 3
NCT03005678	Tuen Mun Hospital	Osteoporosis	April 1, 2017	Phase 4
NCT03925532	Roswell Park Cancer Institute\|Amgen	Allogeneic Hematopoietic Stem Cell Transplantation Recipient\|Osteopenia\|Osteoporosis	December 19, 2019	Phase 2
NCT01770106	Chinese University of Hong Kong	Rheumatoid Arthritis	December 2012	Phase 4
NCT03960554	Thomas Nickolas, MD MS\|Columbia University	Osteoporosis\|Renal Osteodystrophy\|Kidney Transplant; Complications	January 16, 2020	Phase 2
NCT02176382	Massachusetts General Hospital	Postmenopausal Osteoporosis	August 2014	Phase 4
NCT05065164	Shenzhen People´s Hospital	Denosumab and Screw Internal Fixation of Osteoporotic Vertebral Compression Fracture	September 14, 2021	Phase 2\|Phase 3
NCT02491515	Tomidahama Hospital	Osteoporosis	July 2012
NCT00887965	Amgen	Low Bone Mass\|Low Bone Mineral Density\|Osteoporosis\|Postmenopausal Osteoporosis	June 2009	Phase 2
NCT01575834	Amgen	Postmenopausal Osteoporosis	March 15, 2012	Phase 3
NCT00515463	Amgen	Low Bone Mineral Density\|Osteopenia\|Osteoporosis	May 2007	Phase 3
NCT03259152	Hebei Medical University Third Hospital	Giant Cell Tumor of Bone	May 1, 2016	Phase 3
NCT04206618	424 General Military Hospital\|Beth Israel Deaconess Medical Center	Osteoporosis, Postmenopausal	June 1, 2019
NCT01973569	Daiichi Sankyo, Inc.	Rheumatoid Arthritis	October 2013	Not Applicable
NCT03292146	Massachusetts General Hospital\|Amgen	Bone Density\|Bone Loss\|Anorexia Nervosa\|Eating Disorder\|Atypical Anorexia Nervosa	October 25, 2017	Phase 3
NCT01294397	Amgen	Postmenopausal\|Osteopenia\|Rheumatoid Arthritis\|Osteoporosis	March 2011	Phase 1
NCT04087096	Massachusetts General Hospital\|University of California, San Francisco\|San Francisco VA Health Care System	Bariatric Surgery Candidate\|Bone Loss	August 24, 2020	Phase 4
NCT02567279	University Hospital, Montpellier\|University Hospital, Lille\|Nantes University Hospital\|University Hospital, Paris\|University Hospital, Rouen	Anorexia Nervosa	June 1, 2016	Phase 3
NCT03605199	Leiden University Medical Center\|Amgen	Aneurysmal Bone Cysts\|Giant Cell Granuloma\|Osteoblastoma\|Chondroblastoma\|Chondromyxoid Fibroma	June 18, 2018	Phase 2
NCT02304887	Toshihiko Kono\|Tomidahama Hospital	Osteoporosis	January 2006
NCT04608630	Australian and New Zealand Intensive Care Research Centre	Critical Illness\|Osteoporosis	July 15, 2021	Phase 2
NCT05180032	James J. Peters Veterans Affairs Medical Center\|Kessler Institute for Rehabilitation	Osteoporosis\|Spinal Cord Injuries	March 1, 2021	Phase 4
NCT04547348	Ole Lander Svendsen\|Bispebjerg Hospital	Charcot Foot\|Diabetes Mellitus	November 1, 2020	Phase 3
NCT02156960	Shinshu University	Osteoporosis	May 2014	Phase 4
NCT01419717	Amgen	Bone Metastases in Men With Hormone-Refractory Prostate Cancer\|Bone Metastases in Subjects With Advanced Breast Cancer	November 22, 2011	Phase 3
NCT04711109	Alliance for Clinical Trials in Oncology\|National Cancer Institute (NCI)\|Austrian Breast & Colorectal Cancer Study Group (ABCSG)	BRCA1 Mutation\|Breast Cancer\|Breast Diseases\|Breast Neoplasms\|Breast Carcinoma\|Neoplasms	February 23, 2022	Phase 3
NCT01465568	Tuen Mun Hospital	Osteoporosis	December 2011	Phase 4
NCT02321280	University of Manitoba\|University of Toronto\|McMaster University	Crohn Disease	February 2015	Phase 1\|Phase 2
NCT04169698	Ain Shams University\|Nahda University	Osteoporosis, Osteopenia\|Renal Transplant Recipient	October 17, 2019	Phase 2\|Phase 3
NCT01732770	Amgen	Post Menopausal Osteoporosis	November 7, 2012	Phase 4
NCT02435147	HealthEast Care System\|Amgen	Osteoporosis\|Bone Fracture	April 2015
NCT00089661	Amgen	Breast Cancer\|Low Bone Mineral Density\|Osteopenia	October 1, 2004	Phase 3
NCT00330759	Amgen	Bone Metastases	June 1, 2006	Phase 3
NCT00518531	Amgen	Osteoporosis	September 1, 2007	Phase 3
NCT00321620	Amgen	Bone Metastases	April 1, 2006	Phase 3
NCT04067726	Washington University School of Medicine\|National Institutes of Health (NIH)	Dense Breasts	August 27, 2019	Phase 2
NCT03239080	Chinese University of Hong Kong	Rheumatoid Arthritis	June 19, 2017	Phase 2
NCT03324932	Kyoto Prefectural University of Medicine	Breast Cancer	September 25, 2017	Phase 3
NCT00377819	Amgen	Postmenopausal Osteoporosis	September 2006	Phase 3
NCT02771860	University Hospital, Ghent\|Amgen	Hand Osteoarthritis	March 2016	Phase 2
NCT03161756	Melanoma and Skin Cancer Trials Limited\|Peter MacCallum Cancer Centre, Australia\|Amgen\|Bristol-Myers Squibb	Melanoma Stage Iv\|Melanoma Stage Iii\|Melanoma	December 7, 2017	Phase 1\|Phase 2
NCT04621318	Samsung Bioepis Co., Ltd.	Healthy	October 19, 2020	Phase 1
NCT00330460	Amgen	Osteoporosis\|Osteopenia	May 2006	Phase 3
NCT02853539	Stanley Dudrick´s Memorial Hospital	Metabolic Bone Disease	January 2011	Phase 4
NCT02129699	ETOP IBCSG Partners Foundation\|European Organisation for Research and Treatment of Cancer - EORTC\|Amgen	Lung Cancer Non-small Cell Stage IV	January 6, 2015	Phase 3
NCT02418273	Indiana University	Osteoporosis\|Juvenile Rheumatoid Arthritis\|Dermatomyositis\|Polyarthritis\|Systemic Lupus Erythematosis\|Vasculitis\|Glucocorticoid-induced Osteoporosis	August 1, 2019	Phase 1\|Phase 2
NCT02903446	University of Alabama at Birmingham\|University of Auckland, New Zealand	Gout	February 1, 2017	Phase 2
NCT00919711	Amgen	Osteoporosis	September 1, 2009	Phase 3
NCT03921060	University of Texas Southwestern Medical Center	Cystic Fibrosis	September 2, 2021	Phase 4
NCT01869686	Amgen	Healthy Volunteer	June 2013	Phase 1
NCT01457950	GlaxoSmithKline	Osteoporosis, Postmenopausal	November 2011	Phase 3
NCT03520231	University Health Network, Toronto\|Amgen	Urothelial Carcinoma\|Kidney Cancer\|Ureter Cancer\|Bladder Cancer	September 4, 2018	Phase 2
NCT05419427	Lambda Therapeutic Research Ltd.\|Intas Pharmaceutical Limited (Biopharma Division)	Osteoporosis, Postmenopausal	November 11, 2021	Phase 3
NCT05559268	The Affiliated Hospital of Qingdao University	Osteoarthritis, Knee	October 1, 2022	Phase 4
NCT02366130	M.D. Anderson Cancer Center\|Bayer	Breast Cancer	February 11, 2015	Phase 2
NCT03174366	Western University of Health Sciences	Charcot Joint of Foot	May 16, 2017	Phase 3
NCT03629717	Washington University School of Medicine	Breast Cancer Prevention\|Mammographic Density	June 1, 2018	Early Phase 1
NCT04800367	Columbia University\|Amgen	Premenopausal Idiopathic Osteoporosis	March 12, 2021	Phase 2
NCT05415657	Shenzhen People´s Hospital	Osteopenia\|Spine Fusion\|Denosumab Allergy	January 12, 2020	Not Applicable
NCT02758132	University of Hawaii	Prostate Cancer	March 1, 2016	Phase 2
NCT05096195	Western University, Canada\|ICES\|Academic Medical Organization of Southwestern Ontario\|Western University\|The Kidney Foundation of Canada	Kidney Diseases\|Dialysis; Complications\|Fragility Fracture\|Chronic Kidney Disease-Mineral and Bone Disorder	May 2022	Phase 4
NCT02101164	Amgen	Solid Tumor\|Metastatic Bone Disease	November 2014	Phase 4
NCT02049866	Elizabeth Shane\|Creighton University\|Columbia University	Adult Idiopathic Generalized Osteoporosis	November 19, 2014	Phase 2
NCT04026256	Massachusetts General Hospital	Postmenopausal Osteoporosis	September 2, 2019	Phase 4
NCT02632916	Children´s Hospital of Eastern Ontario	Osteoporosis	August 2016	Phase 2
NCT03532087	Borstkanker Onderzoek Groep\|Amgen	Breast Neoplasms	February 2018	Phase 2
NCT01221727	Amgen	Postmenopausal Osteoporosis	November 2010	Phase 1
NCT02760979	Fundació Institut de Recerca de l´Hospital de la Santa Creu i Sant Pau	Bone Resorption	January 2013	Phase 4

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