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[CAS NO. 62201-71-2] 12-O-Methylcarnosic acid
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N7510 |
| Brand: | MCE |
| CAS: | 62201-71-2 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 346.46 |
| Molecular Formula | C21H30O4 |
| SMILES | O=C([C@]12CCCC(C)(C)[C@]1([H])CCC3=C2C(O)=C(OC)C(C(C)C)=C3)O |
Summary
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla , is an active constituent of 5α-reductase inhibition with an IC 50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity [1] [2] .
In Vitro
12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%
[1]
.
12-O-Methylcarnosic acid shows antimicrobial activity against
S. aureus
at 78 μg/mL
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL ( 144.32 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8863 mL | 14.4317 mL | 28.8634 mL |
| 5 mM | 0.5773 mL | 2.8863 mL | 5.7727 mL |
| 10 mM | 0.2886 mL | 1.4432 mL | 2.8863 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution
References
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