[CAS NO. 62201-71-2] 12-O-Methylcarnosic acid

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PRODUCTS SPECIFICATIONS [62201-71-2]

Catalog

HY-N7510

Brand

MCE

CAS

62201-71-2

DESCRIPTION [62201-71-2]

Overview

MDL	-
Molecular Weight	346.46
Molecular Formula	C21H30O4
SMILES	O=C([C@]12CCCC(C)(C)[C@]1([H])CCC3=C2C(O)=C(OC)C(C(C)C)=C3)O

For research use only. We do not sell to patients.

Summary

12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla , is an active constituent of 5α-reductase inhibition with an IC ₅₀ value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity ^[1] ^[2] .

In Vitro

12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7% ^[1] .
12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 144.32 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8863 mL	14.4317 mL	28.8634 mL
5 mM	0.5773 mL	2.8863 mL	5.7727 mL
10 mM	0.2886 mL	1.4432 mL	2.8863 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

* All of the co-solvents are available by MCE.