[CAS NO. 62499-27-8]  Gastrodin

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PRODUCTS SPECIFICATIONS [62499-27-8]

Catalog
HY-N0115
Brand
MCE
CAS
62499-27-8

DESCRIPTION [62499-27-8]

Overview

MDLMFCD00272169
Molecular Weight286.28
Molecular FormulaC13H18O7
SMILESO[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2

For research use only. We do not sell to patients.


Summary

Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.


In Vitro

Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm 2 and 201.9±43.1 cells/mm 2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 349.31 mM )

H 2 O : 100 mg/mL ( 349.31 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4931 mL 17.4654 mL 34.9308 mL
5 mM 0.6986 mL 3.4931 mL 6.9862 mL
10 mM 0.3493 mL 1.7465 mL 3.4931 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (349.31 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

  • 4.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl
4-(Hydroxymethyl)phenyl β-D-glucopyranoside
Gastrodin
4-(β-D-Glucopyranosyloxy)benzyl alcohol
4-Hydroxybenzyl alcohol 4-O-β-D-glucopyranoside
4-(β-D-Glucopyranosyl)-benzylalcohol
Gastrodine