MDL | MFCD00272169 |
---|---|
Molecular Weight | 286.28 |
Molecular Formula | C13H18O7 |
SMILES | O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2 |
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm 2 and 201.9±43.1 cells/mm 2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : ≥ 100 mg/mL ( 349.31 mM )
H 2 O : 100 mg/mL ( 349.31 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.4931 mL | 17.4654 mL | 34.9308 mL |
5 mM | 0.6986 mL | 3.4931 mL | 6.9862 mL |
10 mM | 0.3493 mL | 1.7465 mL | 3.4931 mL |
Add each solvent one by one: PBS
Solubility: 100 mg/mL (349.31 mM); Clear solution; Need ultrasonic
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution