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[CAS NO. 632-85-9] Wogonin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N0400 |
| Brand: | MCE |
| CAS: | 632-85-9 |
Overview
| MDL | MFCD00017736 |
|---|---|
| Molecular Weight | 284.26 |
| Molecular Formula | C16H12O5 |
| SMILES | O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13 |
9 Publications Citing Use of MCE
- [1]Pharmacol Res. 2020 May;155:104751.
- [2]Transl Stroke Res. 2020 Sep 12.
- [3]Oxid Med Cell Longev. 22 Jun 2021.
- [4]J Cell Mol Med. 2021 Jun;25(12):5782-5798.
- [5]Exp Cell Res. 2020 Aug 1;393(1):112054.
- [6]J Immunol Res. 2020 Jun 1;2020:3032425.
- [7]Eur J Pharmacol. 2019 Apr 5;848:121-130
- [8]Curr Issues Mol Biol. 2023, 45(1), 555-570.
- [9]Xenobiotica. 2020 Aug;50(8):906-912.
Summary
IC50 & Target
|
CDK8
|
In Vitro
Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8 [1] . Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 µM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells [2] . Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model [1] . Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 62.5 mg/mL ( 219.87 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5179 mL | 17.5895 mL | 35.1791 mL |
| 5 mM | 0.7036 mL | 3.5179 mL | 7.0358 mL |
| 10 mM | 0.3518 mL | 1.7590 mL | 3.5179 mL |
-
1.
Add each solvent one by one: 0.5% CMC-Na /saline water
Solubility: 24 mg/mL (84.43 mM); Suspended solution; Need ultrasonic
-
2.
References
- [1] He L, et al. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology. 2013 Oct 4;312:36-47.
- [2] Yang L, et al. Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. Biochem Cell Biol. 2009 Dec;87(6):933-42.
- [3] Li HD, et al. Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. Int Immunopharmacol. 2017 Sep;50:95-106.
Synonyms
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