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[CAS NO. 6385-02-0] Meclofenamic acid sodium
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1320 |
| Brand: | MCE |
| CAS: | 6385-02-0 |
Overview
| MDL | MFCD00077376 |
|---|---|
| Molecular Weight | 318.13 |
| Molecular Formula | C14H10Cl2NNaO2 |
| SMILES | O=C(O[Na])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl |
3 Publications Citing Use of MCE
Summary
Meclofenamic acid (Meclofenamate) sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor [1] [2] [3] .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02930005 | The University of Texas Health Science Center, Houston |
Psychotic Disorders|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder
|
August 7, 2015 | Phase 2 |
| NCT02429570 | Memorial Sloan Kettering Cancer Center |
Recurrent Brain Metastases|Progressive Brain Metastases
|
April 22, 2015 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 125 mg/mL ( 392.92 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1434 mL | 15.7168 mL | 31.4337 mL |
| 5 mM | 0.6287 mL | 3.1434 mL | 6.2867 mL |
| 10 mM | 0.3143 mL | 1.5717 mL | 3.1434 mL |
References
- [1] Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.
- [2] Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.
- [3] Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.
Synonyms
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