[CAS NO. 6415-59-4] Sedanolide
PRODUCTS SPECIFICATIONS [6415-59-4]
DESCRIPTION [6415-59-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 194.27 |
| Molecular Formula | C12H18O2 |
| SMILES | O=C1OC(CCCC)C2CCCC=C21 |
Summary
In Vitro
Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Sedanolide increases the activity of glutathione-S-transferase (GST) in the liver, small intestinal mucosa, and forestomach of A/J mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 514.75 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.1475 mL | 25.7374 mL | 51.4748 mL |
| 5 mM | 1.0295 mL | 5.1475 mL | 10.2950 mL |
| 10 mM | 0.5147 mL | 2.5737 mL | 5.1475 mL |
References
- [1] J A Woods, et al. Sedanolide, a Natural Phthalide From Celery Seed Oil: Effect on Hydrogen Peroxide and Tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 and CaCo-2 Human Cell Lines. In Vitr Mol Toxicol. Fall 2001;14(3):233-40.
- [2] Shu-Ling Hsieh, et al. Sedanolide Induces Autophagy Through the PI3K, p53 and NF-κB Signaling Pathways in Human Liver Cancer Cells. Int J Oncol. 2015 Dec;47(6):2240-6.
Synonyms