[CAS NO. 64183-27-3] 2′-Deoxy-2′-fluoroadenosine
PRODUCTS SPECIFICATIONS [64183-27-3]
DESCRIPTION [64183-27-3]
Overview
| MDL | MFCD09750859 |
|---|---|
| Molecular Weight | 269.23 |
| Molecular Formula | C10H12FN5O3 |
| SMILES | NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](O)[C@@H](CO)O3 |
Summary
2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL ( 185.71 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7143 mL | 18.5715 mL | 37.1430 mL |
| 5 mM | 0.7429 mL | 3.7143 mL | 7.4286 mL |
| 10 mM | 0.3714 mL | 1.8571 mL | 3.7143 mL |