[CAS NO. 645-05-6] Altretamine

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PRODUCTS SPECIFICATIONS [645-05-6]

Catelog

HY-B0181

Brand

MCE

CAS

645-05-6

DESCRIPTION [645-05-6]

Overview

MDL	MFCD00549245
Molecular Weight	210.28
Molecular Formula	C9H18N6
SMILES	CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Mol Med (Berl). 2019 Aug;97(8):1183-1193.

Summary

Altretamine is an alkylating antineoplastic agent.

In Vitro

Altretamine is an antineoplastic agent ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00002936	Roswell Park Cancer Institute\|National Cancer Institute (NCI)	Lymphoma\|Sarcoma	July 1996	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL ( 39.61 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7556 mL	23.7778 mL	47.5556 mL
5 mM	0.9511 mL	4.7556 mL	9.5111 mL
10 mM	0.4756 mL	2.3778 mL	4.7556 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kelner MJ, et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.

Synonyms

1,3,5-Triazine-2,4,6-triamine, N²,N²,N⁴,N⁴,N⁶,N⁶-hexamethyl-

Melamine, hexamethyl-

1,3,5-Triazine-2,4,6-triamine, N,N,N′,N′,N′′,N′′-hexamethyl-

N²,N²,N⁴,N⁴,N⁶,N⁶-Hexamethyl-1,3,5-triazine-2,4,6-triamine

NSC 13875

ENT 50852

Hemel

Hexamethylmelamine

HMM

2,4,6-Tris(dimethylamino)-s-triazine

2,4,6-Tris(dimethylamino)-1,3,5-triazine

Altretamine

1,3,5-Tris(dimethylamino)-s-triazine

Hexalen

Hexylen

2-N,2-N,4-N,4-N,6-N,6-N-Hexamethyl-1,3,5-triazine-2,4,6-triamine