[CAS NO. 649748-23-2]  PPACK II diTFA

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PRODUCTS SPECIFICATIONS [649748-23-2]

Catalog
HY-122543
Brand
MCE
CAS
649748-23-2

DESCRIPTION [649748-23-2]

Overview

MDL-
Molecular Weight729.07
Molecular FormulaC29H35ClF6N6O7
SMILESO=C(O)C(F)(F)F.O=C(O)C(F)(F)F.N=C(N)NCCC[C@@H](C(CCl)=O)NC([C@@H](NC([C@H](N)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O

For research use only. We do not sell to patients.

Summary

PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor [1] .


In Vitro

PPACK II (0.62-50 μg/mL) diTFA significantly inhibits B-type natriuretic peptide (BNP) proteolysis [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 342.90 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3716 mL 6.8581 mL 13.7161 mL
5 mM 0.2743 mL 1.3716 mL 2.7432 mL
10 mM 0.1372 mL 0.6858 mL 1.3716 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (2.85 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.85 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.85 mM); Clear solution

* All of the co-solvents are available by MCE.