[CAS NO. 65-49-6] 4-Aminosalicylic acid

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PRODUCTS SPECIFICATIONS [65-49-6]

Catalog

HY-I0447

Brand

MCE

CAS

65-49-6

DESCRIPTION [65-49-6]

Overview

MDL	MFCD00007789
Molecular Weight	153.14
Molecular Formula	C7H7NO3
SMILES	O=C(O)C1=CC=C(N)C=C1O

For research use only. We do not sell to patients.

Summary

4-Aminosalicylic acid (ASA) is an orally active antibiotic and has the potential to treat tuberculosis ^[1] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00417690	Jacobus Pharmaceutical	Crohn´s Disease	January 2007	Phase 2
NCT00495521	Jacobus Pharmaceutical	Crohn´s Disease	June 2007	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 653.00 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5300 mL	32.6499 mL	65.2997 mL
5 mM	1.3060 mL	6.5300 mL	13.0599 mL
10 mM	0.6530 mL	3.2650 mL	6.5300 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (16.32 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (16.32 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (16.32 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Vânia André, et al. Crystal Forms of the Antibiotic 4-Aminosalicylic Acid: Solvates and Molecular Salts with Dioxane, Morpholine, and Piperazine. Cryst. Growth Des. 2009, 9, 12, 5108-5116.

Synonyms

Benzoic acid, 4-amino-2-hydroxy-

Salicylic acid, 4-amino-

4-Amino-2-hydroxybenzoic acid

Apacil

Apas

Deapasil

Pamacyl

Para-Pas

Parasal

Parasalicil

Parasalindon

PAS (acid)

Pasara

Pasem

Pasmed

Pasnodia

Propasa

Rezipas

PASK

2-Hydroxy-4-aminobenzoic acid

Para-aminosalicylic acid

Pasolac

Sanipirol-4

3-Hydroxy-4-carboxyaniline

Paramycin

Gabbropas

Amino-PAS

Osacyl

Pasalon

Entepas

Pasa

PAS

p-Aminosalicylic acid

4-Aminosalicylic acid

4-ASA

4-Carboxy-3-hydroxyaniline

Pamisyl

NSC 2083

NSC 211698

Monopass

Paser

Euteropas

Granupas