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[CAS NO. 65271-80-9] Mitoxantrone

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Catalog:	HY-13502
Brand:	MCE
CAS:	65271-80-9

Overview

MDL	MFCD00242942
Molecular Weight	444.48
Molecular Formula	C22H28N4O6
SMILES	O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O

For research use only. We do not sell to patients.

14 Publications Citing Use of MCE

[1]Cancers. 2020 Aug 4;12(8):2169.
[2]Cell Oncol. 2020 Dec;43(6):1099-1116.
[3]Acta Pharmacol Sin. 2022 Aug 31.
[4]Drug Deliv. 2022 Dec;29(1):2561-2578.
[5]Int J Biol Sci. 2022 Mar 21;18(6):2568-2582.
[6]J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
[7]Exp Cell Res. 2020 Aug 1;393(1):112054.
[8]BMC Cancer. 2021 Oct 13;21(1):1101.
[9]Med Oncol. 2020 Nov 19;37(12):116.
[10]J Pharm Pharmacol. 2022 Jan 5;74(1):41-56.
[11]J Pharm Pharmacol. 23 November 2021.
[12]Pharm Dev Technol. 2021 Apr 30;1-9.
[13]bioRxiv. 2023 Jan 13.
[14]Research Square Print. November 28th, 2022.

Summary

Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C ( PKC ) activity with an IC ₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity ^[1] ^[2] ^[3] ^[4] . Mitoxantrone also has anti- orthopoxvirus activity with EC ₅₀ s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively ^[5] .

IC50 & Target

PKC

8.5 μM (IC ₅₀ )

Topoisomerase II

In Vitro

Mitoxantrone inhibits PKC in a competitive manner with respect to histone H1, and its K _i value is 6.3 μM and in a non-competitive manner with respect to phosphatidylserine and ATP ^[1] .
Mitoxantrone (0.5 μg/mL, 48 h) induces a decrease in B-CLL cells. Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), demonstrating that the cytotoxic effect of Mitoxantrone is due to induction of apoptosis ^[2] .
Mitoxantrone shows cytotoxicity to human breast carcinoma cell lines MDA-MB-231 and MCF-7 with IC ₅₀ values of 18 and 196 nM, respectively ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mitoxantrone (IP, 0-3.2 mg/kg/day) produces a statistically significant number of 60-day survivors at 1.6 mg/kg in mice with IP implanted L1210 leukemia ^[4] .
Mitoxantrone (IV, 0-3.2 mg/kg/day) shows effective antitumor activities and produces a 60% ILS (increase in lifespan) at 3.2 mg/kg in SC implanted Lewis lung carcinoma ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00003893	University Hospital Birmingham\|National Cancer Institute (NCI)	Breast Cancer	July 1998	Phase 3
NCT00003183	Hope Cancer Institute, Inc.\|National Cancer Institute (NCI)	Prostate Cancer	March 1997	Phase 1\|Phase 2
NCT00002819	Gynecologic Oncology Group\|National Cancer Institute (NCI)\|Eastern Cooperative Oncology Group\|Southwest Oncology Group\|Cancer and Leukemia Group B\|GOG Foundation	Ovarian Cancer	November 1996	Phase 3
NCT05495100	Second Affiliated Hospital, School of Medicine, Zhejiang University\|Ningbo No. 1 Hospital\|Jinhua Central Hospital\|Huizhou Municipal Central Hospital	Peripheral T Cell Lymphoma	August 11, 2022	Phase 2
NCT00458848	Gruppo Italiano Malattie EMatologiche dell´Adulto	Leukemia	October 2004	Phase 2
NCT00002719	European Organisation for Research and Treatment of Cancer - EORTC\|Gruppo Italiano Malattie EMatologiche dell´Adulto	Leukemia\|Neutropenia	December 1995	Phase 3
NCT01065727	Rennes University Hospital	Multiple Sclerosis	February 2010	Not Applicable
NCT00274807	The Cleveland Clinic\|National Cancer Institute (NCI)	Leukemia	June 2001	Phase 2
NCT05100329	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Pancreatic Cancer	November 2021	Phase 2
NCT00003407	Rush University Medical Center\|National Cancer Institute (NCI)	Drug+Agent Toxicity by Tissue+Organ\|Leukemia\|Myelodysplastic Syndromes\|Neutropenia	April 1998	Phase 2
NCT00278213	German CLL Study Group	Prolymphocytic Leukemia	September 2002	Phase 2
NCT02573363	University of Chicago\|National Cancer Institute (NCI)	Acute Myeloid Leukemia	October 7, 2015	Phase 1
NCT00004197	University of Nebraska\|National Cancer Institute (NCI)	Lymphoma	June 1999	Phase 2
NCT05458180	Tianjin Medical University Cancer Institute and Hospital\|CSPC Ouyi Pharmaceutical Co., Ltd.	Peripheral T-cell Lymphoma	July 7, 2022	Phase 1
NCT01627938	PD Dr. Andrew Chan\|Ruhr University of Bochum	Multiple Sclerosis	April 2012	Phase 2
NCT01830777	Massachusetts General Hospital	Acute Myelogenous Leukemia	May 2013	Phase 1
NCT00774046	University of Chicago	Myelodysplastic Syndrome\|Acute Myeloid Leukemia	December 2002	Phase 2
NCT00656084	US Oncology Research\|Eli Lilly and Company	Relapsed or Refractory Mantle Cell Lymphoma (MCL)	December 2004	Phase 2
NCT01144403	Hoffmann-La Roche	Diffuse Large B-Cell Lymphoma	June 2010	Phase 2
NCT04196010	University of Washington	Myeloid Neoplasm\|Recurrent Acute Myeloid Leukemia\|Refractory Acute Myeloid Leukemia	May 8, 2020	Phase 1
NCT01249430	National Cancer Institute (NCI)	Recurrent Adult Acute Myeloid Leukemia\|Refractory Acute Myeloid Leukemia	January 20, 2011	Phase 1
NCT00609739	Masonic Cancer Center, University of Minnesota	Leukemia	June 1999	Phase 1\|Phase 2
NCT01729845	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Previously Treated Myelodysplastic Syndrome\|Recurrent Adult Acute Myeloid Leukemia	December 20, 2012	Phase 1\|Phase 2
NCT04024241	Shenzhen People´s Hospital	Acute Myelogenous Leukemia\|Chemotherapy	September 1, 2017
NCT00193479	SCRI Development Innovations, LLC\|Genentech, Inc.\|Amgen	Non-Hodgkins Lymphoma	April 2003	Phase 2
NCT00002835	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Lymphoma	October 30, 1995	Phase 3
NCT00002565	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Lymphoma	May 25, 1994	Phase 3
NCT05441761	Peking Union Medical College Hospital\|CSPC Ouyi Pharmaceutical Co., Ltd.	Treatment\|Peripheral T-cell Lymphoma	May 1, 2022	Phase 1\|Phase 2
NCT00627354	Groupe D´Etude des Tumeurs Uro-Genitales\|National Cancer Institute (NCI)	Prostate Cancer	September 2006	Phase 2
NCT01681537	Massachusetts General Hospital	Acute Myelogenous Leukemia	September 2012	Phase 1
NCT04668690	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Peripheral T Cell Lymphoma	January 1, 2021	Phase 3
NCT00556127	Gruppo Italiano Multiregionale per lo studio dei Linfomi e delle Leucemie	Diffuse Large B-Cell Lymphoma\|POOR PROGNOSIS	June 2002	Phase 2
NCT01342887	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Recurrent Adult Acute Myeloid Leukemia	April 2011	Phase 1\|Phase 2
NCT01154439	Gruppo Italiano Malattie EMatologiche dell´Adulto	Leukemia	October 2010	Phase 1
NCT00079105	Newcastle-upon-Tyne Hospitals NHS Trust	Lymphoma	January 2004	Phase 2
NCT00002766	Memorial Sloan Kettering Cancer Center\|National Cancer Institute (NCI)	Leukemia\|Lymphoma	March 1996	Phase 3
NCT00003602	Riverside Haematology Group\|National Cancer Institute (NCI)	Leukemia\|Myelodysplastic Syndromes	March 1998	Phase 3
NCT02021825	Xuanwu Hospital, Beijing	Neuromyelitis Optica\|Neuromyelitis Optica Spectrum Disorders	March 2009	Phase 4
NCT00059631	M.D. Anderson Cancer Center\|Millennium Pharmaceuticals, Inc.\|National Cancer Institute (NCI)	Prostate Cancer	March 20, 2003	Phase 1
NCT02937285	Rennes University Hospital	Multiple Sclerosis	November 2010	Phase 3
NCT00661492	US Oncology Research\|Eli Lilly and Company\|Oregon Health and Science University	Androgen-independent Prostate Cancer	May 2008	Phase 2
NCT02518750	St. Jude Children´s Research Hospital\|Novartis Pharmaceuticals\|Spectrum Pharmaceuticals, Inc	Acute Lymphoblastic Leukemia\|Lymphoma, Non-Hodgkin´s\|Leukemia, T-Cell\|Leukemia, B-Cell	November 23, 2016	Phase 2
NCT00032149	Lymphoma Trials Office\|National Cancer Institute (NCI)	Lymphoma	October 2001	Phase 1\|Phase 2
NCT00795002	National Cancer Institute (NCI)	Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome\|Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia	November 2008	Phase 2
NCT02597387	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Relapsed DLBCL and PT+NKCLs	August 2015	Phase 2
NCT01564784	Pfizer\|UCB Pharma	Acute Lymphoblastic Leukemia	August 2, 2012	Phase 3
NCT00003633	Herbert Irving Comprehensive Cancer Center\|National Cancer Institute (NCI)	Prostate Cancer	August 1998	Phase 1
NCT03012672	University of Washington\|National Cancer Institute (NCI)	Acute Leukemia of Ambiguous Lineage\|Acute Myeloid Leukemia\|Myeloid Neoplasm	December 30, 2016	Phase 2
NCT00268242	The Cleveland Clinic\|National Cancer Institute (NCI)\|Duke University	Leukemia	January 2006	Phase 2
NCT02462265	Oshadi Drug Administration	Acute Myeloid Leukemia\|Lymphoid Leukemia	January 2017	Phase 2
NCT02688140	Technische Universität Dresden\|Gruppo Italiano Malattie EMatologiche dell´Adulto\|Groupe Francophone des Myelodysplasies\|HOVON - Dutch Haemato-Oncology Association\|Programa para el Tratamiento de Hemopatías Malignas\|German Federal Ministry of Education and Research\|Teva Pharmaceuticals Europe	Acute Promyelocytic Leukemia	June 2016	Phase 3
NCT05496894	CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.	Relapsing Multiple Sclerosis	August 2022	Phase 2
NCT00004237	Royal Marsden NHS Foundation Trust\|National Cancer Institute (NCI)	Breast Cancer	October 1998	Phase 2
NCT02521493	Children´s Oncology Group\|National Cancer Institute (NCI)	Acute Myeloid Leukemia\|Down Syndrome\|Myelodysplastic Syndrome\|Myeloid Leukemia Associated With Down Syndrome\|Myeloproliferative Neoplasm	November 23, 2015	Phase 3
NCT03591510	Novartis Pharmaceuticals\|Novartis	FLT3-mutated Acute Myeloid Leukemia	March 13, 2019	Phase 2
NCT00003650	UNICANCER	Lymphoma	February 1997	Phase 3
NCT00028899	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia\|Myelodysplastic Syndromes	July 2002	Phase 1
NCT00016016	National Cancer Institute (NCI)	Recurrent Adult Acute Lymphoblastic Leukemia\|Recurrent Adult Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Lymphoblastic Leukemia\|Untreated Adult Acute Myeloid Leukemia	February 2001	Phase 1\|Phase 2
NCT02687386	Dr David Ziegler\|Engeneic Pty Limited\|Sydney Children´s Hospitals Network	Solid Tumours\|CNS Tumours	February 8, 2016	Phase 1
NCT01260714	National Cancer Institute (NCI)	Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome\|Adult Acute Basophilic Leukemia\|Adult Acute Eosinophilic Leukemia\|Adult Acute Megakaryoblastic Leukemia\|Adult Acute Monoblastic Leukemia\|Adult Acute Monocytic Leukemia\|Adult Acute Myeloid Leukemia in Remission\|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11\|Adult Acute Myeloid Leukemia With Maturation\|Adult Acute Myeloid Leukemia With Minimal Differentiation\|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1\|Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL\|Adult Acute Myeloid Leukemia Without Maturation\|Adult Acute Myelomonocytic Leukemia\|Adult Erythroleukemia\|Adult Pure Erythroid Leukemia\|Alkylating Agent-Related Acute Myeloid Leukemia\|Recurrent Adult Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia	December 2010	Phase 1
NCT05551598	CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.	Neuromyelitis Optica Spectrum Disorder	November 15, 2022	Phase 2
NCT00003436	Medical Research Council\|National Cancer Institute (NCI)	Leukemia\|Myelodysplastic Syndromes	July 1998	Phase 3
NCT00003297	Georgetown University\|National Cancer Institute (NCI)	Ovarian Cancer	December 1997	Phase 1\|Phase 2
NCT02339740	Children´s Oncology Group\|National Cancer Institute (NCI)	Acute Promyelocytic Leukemia With PML-RARA	June 29, 2015	Phase 3
NCT00003068	University of Arizona\|National Cancer Institute (NCI)	Breast Cancer\|Drug+Agent Toxicity by Tissue+Organ	June 1997	Phase 2
NCT00003003	Dartmouth-Hitchcock Medical Center\|National Cancer Institute (NCI)	Leukemia	September 1996	Phase 1
NCT00002544	Arbeitsgemeinschaft fur Internistische Onkologie\|National Cancer Institute (NCI)	Breast Cancer	May 1993	Phase 3
NCT05299164	Institute of Hematology & Blood Diseases Hospital\|CSPC Ouyi Pharmaceutical Co., Ltd.	Non Hodgkin Lymphoma	May 15, 2022	Phase 1
NCT05575973	Jianfeng Zhou\|CSPC Ouyi Pharmaceutical Co., Ltd.\|Huazhong University of Science and Technology	Diffuse Large B-cell Lymphoma	October 10, 2022	Phase 2
NCT02419755	St. Jude Children´s Research Hospital	Mixed Lineage Acute Leukemia\|Acute Myeloid Leukemia\|Acute Lymphoid Leukemia	April 14, 2015	Phase 2
NCT00840684	Institut Paoli-Calmettes\|National Cancer Institute (NCI)	Leukemia	January 2009	Phase 1\|Phase 2
NCT00058084	National Cancer Institute (NCI)	Adenocarcinoma of the Prostate\|Recurrent Prostate Cancer\|Stage IV Prostate Cancer	March 2003	Phase 2
NCT00853008	PETHEMA Foundation	Acute Lymphoblastic Leukemia	January 2003	Phase 4
NCT02200978	South China Children´s Leukemia Group	Childhood Acute Promyelocytic Leukemia	September 2011	Phase 4
NCT00004124	Southwest Oncology Group\|National Cancer Institute (NCI)\|Cancer and Leukemia Group B	Prostate Cancer	October 1999	Phase 3
NCT00199069	Johann Wolfgang Goethe University Hospital\|Deutsche Krebshilfe e.V., Bonn (Germany)	Adult Acute Lymphocytic Leukemia	April 1993	Phase 4
NCT00546377	Memorial Sloan Kettering Cancer Center\|National Cancer Institute (NCI)	Leukemia\|Lymphoma	July 2005	Phase 1\|Phase 2
NCT00882076	Milton S. Hershey Medical Center	Leukemia	March 2009	Phase 1
NCT05522192	Hui Zeng\|CSPC Ouyi Pharmaceutical Co., Ltd.\|First Affiliated Hospital of Jinan University	Relapsed or Refractory Acute Myeloid Leukemia	July 21, 2022	Phase 1\|Phase 2
NCT00107354	Fred Hutchinson Cancer Center	Leukemia\|Myelodysplastic Syndromes	December 1998	Phase 1
NCT02400281	Arog Pharmaceuticals, Inc.	Acute Myeloid Leukemia	September 2015	Phase 1\|Phase 2
NCT04331743	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Hepatocellular Carcinoma	June 5, 2021	Phase 1
NCT05313958	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University\|Third Affiliated Hospital, Sun Yat-Sen University\|Maternal and Child Health Hospital of Foshan\|The First Affiliated Hospital of Guangzhou Medical University\|Second Xiangya Hospital of Central South University\|Jiangxi Province Children´s Hospital\|Southern Medical University, China\|The First Affiliated Hospital of Nanchang University\|Guangzhou First People´s Hospital\|First Affiliated Hospital of Shantou University Medical College	Leukemia, Monocytic, Acute\|Pediatric AML	December 1, 2021	Phase 2\|Phase 3
NCT03776279	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Relapsed or Refractory Peripheral T-cell and NK+T-cell Lymphoma	April 2, 2018	Phase 2
NCT00562965	Pfizer\|UCB Pharma	Lymphoma, Follicular	November 2007	Phase 3
NCT00906945	Washington University School of Medicine	Leukemia, Myeloid, Acute	February 2011	Phase 1\|Phase 2
NCT04293562	Children´s Oncology Group\|National Cancer Institute (NCI)	Acute Myeloid Leukemia	July 20, 2020	Phase 3
NCT01483690	Therapeutic Advances in Childhood Leukemia Consortium	Acute Lymphoblastic Leukemia\|Precursor B-Cell Lymphoblastic Leukemia\|Precursor T-Cell Lymphoblastic Leukemia	December 2011	Phase 1\|Phase 2
NCT01349972	National Cancer Institute (NCI)	Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia	April 2011	Phase 2
NCT02686593	The University of Hong Kong	Acute Myeloid Leukemia	February 1, 2016	Phase 2
NCT01004497	The Catholic University of Korea	Acute Lymphoblastic Leukemia	March 2010	Phase 2
NCT04902027	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Recurrent Head and Neck Cancer\|Metastatic Head and Neck Cancer	July 1, 2021	Phase 1
NCT00003405	Rush University Medical Center\|National Cancer Institute (NCI)	Leukemia	April 1998	Phase 2
NCT00180128	Technische Universität Dresden	Leukemia, Promyelocytic, Acute	January 2000	Phase 4
NCT00109837	Southwest Oncology Group\|National Cancer Institute (NCI)	Leukemia	April 2005	Phase 2
NCT00053131	Roswell Park Cancer Institute	Leukemia	January 1999	Phase 2
NCT00372593	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	August 2006	Phase 3
NCT03563560	Sumitomo Pharma Co., Ltd.	Acute Myeloid Leukemia	May 15, 2018	Phase 1
NCT00634244	National Cancer Institute (NCI)	Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Recurrent Adult Acute Myeloid Leukemia	October 2008	Phase 2
NCT00006250	Lymphoma Trials Office\|National Cancer Institute (NCI)	Lymphoma	May 2000	Phase 3
NCT00005823	Leukemia Research Fund\|National Cancer Institute (NCI)	Leukemia\|Myelodysplastic Syndromes\|Myelodysplastic+Myeloproliferative Neoplasms	December 1998	Phase 3
NCT02198482	University of Ulm	Acute Myeloid Leukemia (AML)\|High-risk Myelodysplastic Syndrome (MDS)	February 2016	Phase 2
NCT00002912	National Cancer Institute (NCI)	Leukemia	January 1997	Phase 1
NCT00274963	German CLL Study Group	Chronic Lymphocytic Leukemia	October 2004	Phase 2
NCT02523976	Institute of Hematology & Blood Diseases Hospital	Acute,Leukemia, Lymphoid	August 1, 2015	Phase 2
NCT03735446	Dana-Farber Cancer Institute\|Eli Lilly and Company	Acute Myeloid Leukemia\|Myelodysplastic Syndromes	January 18, 2019	Phase 1
NCT00526305	PETHEMA Foundation	Acute Lymphoblastic Leukemia	January 2000	Phase 4
NCT00003728	European Organisation for Research and Treatment of Cancer - EORTC\|National Cancer Institute (NCI)	Leukemia\|Lymphoma	December 1998	Phase 3
NCT00005998	Masonic Cancer Center, University of Minnesota\|National Cancer Institute (NCI)	Lymphoma	January 2000	Phase 2
NCT02626338	Arog Pharmaceuticals, Inc.	Relapsed+Refractory Acute Myeloid Leukemia (AML)	February 2016	Phase 1\|Phase 2
NCT03250338	Arog Pharmaceuticals, Inc.	Relapsed+Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations	June 5, 2018	Phase 3
NCT01204710	Eli Lilly and Company	Prostate Cancer	October 2010	Phase 2
NCT02553460	St. Jude Children´s Research Hospital\|Gateway for Cancer Research\|Baylor College of Medicine	Acute Lymphoblastic Leukemia	January 29, 2016	Phase 1\|Phase 2
NCT05345938	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Relapsed or Refractory Acute Myeloid Leukemia (AML)	May 30, 2022	Phase 1\|Phase 2
NCT00003957	Fox Chase Cancer Center\|National Cancer Institute (NCI)	Lymphoma	December 1998	Phase 2
NCT05344742	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Solid Tumor	April 2022	Phase 1
NCT00254410	M.D. Anderson Cancer Center\|OSI Pharmaceuticals\|Genentech, Inc.	Chronic Lymphocytic Leukemia	March 14, 2005	Phase 2
NCT00866918	Children´s Oncology Group\|National Cancer Institute (NCI)	Childhood Acute Promyelocytic Leukemia With PML-RARA\|Myeloid Neoplasm	March 9, 2009	Phase 3
NCT02733380	Henan Cancer Hospital	Diffuse Large B-cell Lymphoma	May 2016	Phase 2
NCT05527275	Sun Yat-sen University	Relapsed and Refractory Peripheral T-cell Lymphoma	October 1, 2022	Phase 1\|Phase 2
NCT01174888	Alison Walker\|Novartis\|Millennium Pharmaceuticals, Inc.\|Ohio State University Comprehensive Cancer Center	Acute Myeloid Leukemia\|Acute Myeloid Leukemia With Multilineage Dysplasia Following\|Myelodysplastic Syndrome\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Recurrent Adult Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia	August 2010	Phase 1
NCT04927481	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Breast Cancer	June 11, 2021	Phase 2
NCT04719065	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Solid Tumor	January 13, 2021	Phase 1
NCT00470197	National Cancer Institute (NCI)	Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Malignant Neoplasm\|Recurrent Adult Acute Lymphoblastic Leukemia\|Recurrent Adult Acute Myeloid Leukemia	April 2007	Phase 1
NCT00901927	M.D. Anderson Cancer Center\|Cephalon	Follicular Lymphoma	May 2009	Phase 2
NCT01027923	Washington University School of Medicine	Leukemia, Myeloid, Acute	May 2010	Phase 1
NCT00967057	Children´s Cancer and Leukaemia Group\|National Cancer Institute (NCI)	Leukemia	October 2002	Phase 3
NCT05173545	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Recurrent+Refractory Lymphoma	July 29, 2019	Phase 1
NCT00304291	State University of New York at Buffalo\|EMD Serono	Neuromyelitis Optica\|Myelitis, Transverse\|Demyelinating Autoimmune Diseases, CNS\|Autoimmune Diseases of the Nervous System	August 2001	Phase 4
NCT00182741	OHSU Knight Cancer Institute\|National Cancer Institute (NCI)	Prostate Cancer	September 2004	Phase 2
NCT02131688	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Malignant Lymphoma	May 2013	Phase 1
NCT02856685	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Non-Hodgkin´s Lymphoma	August 2016	Phase 1\|Phase 2
NCT00143975	University of Ulm	Leukemia, Myeloid, Acute	June 2004	Phase 2
NCT02306291	GlycoMimetics Incorporated	Leukemia, Myeloid, Acute	March 2015	Phase 1\|Phase 2
NCT01522443	Exelixis	Prostate Cancer\|Castration Resistant Prostate Cancer\|Pain\|Prostatic Neoplasms	March 2012	Phase 3
NCT00002576	Cancer Research Campaign Clinical Trials Centre\|National Cancer Institute (NCI)	Lymphoma	November 1992	Phase 3
NCT00047021	Case Comprehensive Cancer Center\|National Cancer Institute (NCI)	Leukemia\|Lymphoma	November 2001	Phase 2
NCT02728050	University of Washington\|National Cancer Institute (NCI)\|Bayer	Acute Biphenotypic Leukemia\|Acute Myeloid Leukemia\|de Novo Myelodysplastic Syndrome\|Myelodysplastic Syndrome\|Myeloproliferative Neoplasm	December 1, 2016	Phase 1\|Phase 2
NCT00100477	US Department of Veterans Affairs\|Immunex Corporation\|SmithKline Beecham\|Amgen\|VA Office of Research and Development	Non-Hodgkin´s Lymphoma\|Leukemia	August 1998	Phase 2
NCT00006122	European Organisation for Research and Treatment of Cancer - EORTC	Leukemia	June 2000	Phase 2
NCT00003215	Swiss Group for Clinical Cancer Research	Lymphoma	April 1997	Phase 3
NCT00512252	Washington University School of Medicine	Leukemia, Myeloid, Acute	July 2007	Phase 1\|Phase 2
NCT00290511	M.D. Anderson Cancer Center\|Genentech, Inc.\|Biogen	Lymphoma	June 29, 2004	Phase 2
NCT05464433	Sun Yat-sen University	Extranodal Natural Killer T Cell Lymphoma	July 30, 2022	Phase 1\|Phase 2
NCT02461537	DKMS gemeinnützige GmbH	Acute Myeloid Leukemia	September 17, 2015	Phase 3
NCT03926624	Delta-Fly Pharma, Inc.	Leukemia, Myeloid, Acute	November 22, 2019	Phase 3
NCT02044796	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Acute Biphenotypic Leukemia\|de Novo Myelodysplastic Syndrome\|Previously Treated Myelodysplastic Syndrome\|Recurrent Adult Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia	January 23, 2014	Phase 1\|Phase 2
NCT04797767	University of Washington\|AbbVie	Acute Biphenotypic Leukemia\|Acute Myeloid Leukemia\|Mixed Phenotype Acute Leukemia\|Myeloid Neoplasm\|Relapsed Acute Biphenotypic Leukemia\|Relapsed Acute Myeloid Leukemia\|Relapsed Mixed Phenotype Acute Leukemia\|Relapsed Myeloid Neoplasm\|Refractory Acute Biphenotypic Leukemia\|Refractory Acute Myeloid Leukemia\|Refractory Mixed Phenotype Acute Leukemia\|Refractory Myeloid Neoplasm	February 4, 2022	Phase 1
NCT04548700	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Treatment-naïve\|Peripheral T Cell Lymphoma	December 24, 2020	Phase 1
NCT04778410	Gilead Sciences	Myeloid Malignancies	June 28, 2021	Phase 2
NCT04509466	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Extranodal NK+T-cell Lymphoma, Nasal Type	August 15, 2020	Phase 1\|Phase 2
NCT00146159	Wyeth is now a wholly owned subsidiary of Pfizer	Secondary Progressive Multiple Sclerosis	March 2005	Phase 3
NCT00003858	Alliance for Clinical Trials in Oncology\|National Cancer Institute (NCI)	Prostate Cancer		Phase 2
NCT02848183	Samsung Medical Center	Pediatric Acute Myeloid Leukemia	January 2016	Phase 2
NCT00124566	Eisai Inc.	Prostate Cancer	June 2004	Phase 2
NCT02756572	University of Washington\|National Cancer Institute (NCI)	Blasts 10 Percent or More of Bone Marrow Nucleated Cells\|Chronic Myelomonocytic Leukemia-2\|High Grade Malignant Neoplasm\|Myelodysplastic Syndrome\|Myelodysplastic Syndrome With Excess Blasts-2\|Myeloid Neoplasm\|Previously Treated Myelodysplastic Syndrome\|Recurrent Acute Myeloid Leukemia\|Refractory Acute Myeloid Leukemia	September 22, 2016	Phase 2
NCT00337246	Cancer Research UK\|National Cancer Institute (NCI)	Leukemia	July 2005	Phase 2
NCT00119730	Dana-Farber Cancer Institute\|Massachusetts General Hospital\|Biogen	Mantle Cell Lymphoma	February 2005	Phase 2
NCT03258320	Shanghai Jiao Tong University School of Medicine\|Fudan University\|Qilu Hospital of Shandong University	Prostate Cancer Patients	January 2015	Phase 1
NCT02101853	National Cancer Institute (NCI)	Recurrent B Acute Lymphoblastic Leukemia	December 8, 2014	Phase 3
NCT00003032	NCIC Clinical Trials Group\|Canadian Cancer Trials Group	Breast Cancer	April 25, 1997	Phase 3
NCT03118466	Massachusetts General Hospital\|Celgene	AML	September 25, 2017	Phase 2
NCT02303821	Amgen\|Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) - Study Design & Execution Collaborator\|Innovative Therapies For Children with Cancer Consortium	Acute Lymphoblastic Leukemia (ALL)	February 16, 2015	Phase 1
NCT02043756	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Neoplasms	August 2011	Phase 1
NCT00499018	Fondazione Italiana Linfomi ONLUS\|Centro di Riferimento per l´Epidemiologia e la Prev. Oncologica Piemonte	Diffuse Large B-Cell Lymphoma\|IPI?2	January 2006	Phase 3
NCT03504410	Cornerstone Pharmaceuticals	Relapsed+Refractory Acute Myeloid Leukemia	November 12, 2018	Phase 3
NCT00317408	European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma\|National Cancer Institute (NCI)	Lymphoma	April 2004	Not Applicable
NCT02484391	Wake Forest University Health Sciences\|National Cancer Institute (NCI)	Granulocytic Sarcoma\|Recurrent Adult Acute Myeloid Leukemia	September 2015	Phase 2
NCT01828489	Vastra Gotaland Region	Pediatric Acute Myeloblastic Leukemia	March 2013	Phase 3
NCT00004071	Pfizer	Prostate Cancer	August 1999	Phase 2\|Phase 3
NCT01768897	Wake Forest University Health Sciences\|National Cancer Institute (NCI)	Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Recurrent Adult Acute Myeloid Leukemia	January 2013	Phase 1
NCT00477087	Stanford University\|Bayer	Prostatic Neoplasms	July 2006	Phase 2
NCT02520011	Sumitomo Pharma Oncology, Inc.	Acute Myeloid Leukemia	March 14, 2016	Phase 2
NCT00331344	National Cancer Institute (NCI)	Adenocarcinoma of the Prostate\|Recurrent Prostate Cancer\|Stage IV Prostate Cancer	April 2006	Phase 1\|Phase 2
NCT04718402	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Gastric Carcinoma	March 30, 2021	Phase 1
NCT00002701	European Organisation for Research and Treatment of Cancer - EORTC\|Gruppo Italiano Malattie EMatologiche dell´Adulto\|National Cancer Institute (NCI)	Leukemia	October 1995	Phase 3
NCT00002259	Lederle Laboratories\|NIH AIDS Clinical Trials Information Service	Sarcoma, Kaposi\|HIV Infections		Phase 2
NCT00002003	Lederle Laboratories\|NIH AIDS Clinical Trials Information Service	Lymphoma, Non-Hodgkin\|HIV Infections		Phase 2
NCT00447473	The Methodist Hospital Research Institute\|Bayer	Prostatic Neoplasms	July 2006	Phase 2
NCT00660036	University of Pittsburgh	Acute Myeloid Leukemia	September 2008	Phase 1
NCT00151255	University of Ulm	Acute Myeloid Leukemia	June 2004	Phase 3
NCT00416910	German CLL Study Group	Chronic Lymphocytic Leukemia	July 1999	Phase 3
NCT00005985	Masonic Cancer Center, University of Minnesota	Lymphoma	August 2000	Phase 2
NCT00407966	National Cancer Institute (NCI)	Adult Acute Basophilic Leukemia\|Adult Acute Eosinophilic Leukemia\|Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia	October 2006	Phase 2
NCT00842595	French Innovative Leukemia Organisation	Diffuse Large B-Cell Lymphoma	December 2003	Phase 2
NCT01594918	Rahul Aggarwal\|Sanofi\|University of California, San Francisco	Metastatic Castration-resistant Prostate Cancer	June 2012	Phase 1
NCT00003343	Pfizer	Prostate Cancer	March 1998	Phase 3
NCT01904643	Stanford University\|National Cancer Institute (NCI)	Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Recurrent Adult Acute Myeloid Leukemia	February 2014	Phase 1
NCT03839446	Konstantinos Lontos\|Pfizer\|University of Pittsburgh	Acute Myeloid Leukemia	February 28, 2019	Phase 2
NCT02583893	Sidney Kimmel Cancer Center at Thomas Jefferson University\|Thomas Jefferson University	Recurrent Adult Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia	October 7, 2015	Phase 2
NCT00002688	University Medical Center Groningen\|National Cancer Institute (NCI)	Leukemia	February 1995	Phase 2
NCT00002905	Centro di Riferimento Oncologico - Aviano\|National Cancer Institute (NCI)	Lymphoma	June 1995	Phase 2
NCT00183989	University of Southern California	Mantle Cell Lymphoma	August 2000	Phase 2
NCT00005867	Lymphoma Trials Office\|National Cancer Institute (NCI)	Lymphoma	January 1998	Phase 3
NCT00452387	Accelerated Community Oncology Research Network\|Bayer	Metastatic Prostate Cancer	May 2007	Phase 2
NCT00017563	OHSU Knight Cancer Institute\|National Cancer Institute (NCI)	Prostate Cancer	September 2000	Phase 2
NCT01371981	National Cancer Institute (NCI)	Acute Myeloid Leukemia\|Leukemia Cutis\|Myeloid Neoplasm\|Myeloid Sarcoma	June 20, 2011	Phase 3
NCT00436839	Sanofi	Prostatic Neoplasms	January 2007	Phase 3
NCT00550992	Dutch Childhood Oncology Group\|BFM Germany\|CORS Monza Italy\|Associazione Italiana Ematologia Oncologia Pediatrica\|Australian and New Zealand Children´s Oncology Group\|BFM Austria\|CLCG France Belgium Portugal\|COALL Germany\|CPH, Czech republic\|DFCI consortium USA\|FRALLE France\|Hong Kong\|MD Anderson USA\|NOPHO Scandinavian countries\|PINDA, Chile\|PPLLSG Poland\|Seattle USA\|SJCRH USA\|UKCCSG United Kingdom	Leukemia	January 2006	Not Applicable
NCT02631252	Alison Sehgal, MD, MS\|University of Pittsburgh	Leukemia, Acute Myelogenous	August 18, 2016	Phase 1
NCT02299518	Bhavana Bhatnagar\|Karyopharm Therapeutics Inc\|Ohio State University Comprehensive Cancer Center	Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Recurrent Adult Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia	May 18, 2015	Phase 1
NCT02596373	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Recurrent or Metastatic Breast Cancer	June 2015	Phase 2
NCT00770848	Amgen	Cancer\|Castrate-Resistant Prostate Cancer\|Mestastatic Prostate Cancer\|Prostate Cancer	November 2008	Phase 1\|Phase 2
NCT01839240	University of Chicago\|National Cancer Institute (NCI)	Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia in Remission\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Recurrent Adult Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia	June 6, 2012	Phase 1
NCT00510887	Duke University\|Millennium Pharmaceuticals, Inc.	Lymphoma, Follicular	January 2007	Phase 2
NCT00408278	PETHEMA Foundation	Acute Promyelocytic Leukemia	July 2005	Phase 4
NCT00002531	Johann Wolfgang Goethe University Hospital\|National Cancer Institute (NCI)	Leukemia	January 1993	Phase 2
NCT04375631	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Recurrent Acute Myeloid Leukemia\|Recurrent Chronic Myelomonocytic Leukemia\|Recurrent Myelodysplastic Syndrome\|Refractory Acute Myeloid Leukemia\|Refractory Chronic Myelomonocytic Leukemia\|Refractory Mixed Phenotype Acute Leukemia\|Refractory Myelodysplastic Syndrome\|Refractory Acute Leukemia of Ambiguous Lineage\|Refractory Acute Undifferentiated Leukemia	December 3, 2020	Phase 1
NCT00002474	Loyola University\|National Cancer Institute (NCI)	Ovarian Cancer	February 1991	Phase 2
NCT03164057	St. Jude Children´s Research Hospital	Acute Myeloid Leukemia\|Myelodysplastic Syndromes	June 15, 2017	Phase 2
NCT00002805	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	August 1997	Phase 2
NCT02535806	Children´s Mercy Hospital Kansas City\|Millennium Pharmaceuticals, Inc.	Acute Lymphoblastic Leukemia\|Lymphoblastic Lymphoma	July 2015	Phase 2
NCT00005802	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Leukemia	June 1999	Phase 1\|Phase 2
NCT00015951	University of Maryland, Baltimore\|National Cancer Institute (NCI)\|University of Maryland Greenebaum Cancer Center	Leukemia\|Myelodysplastic Syndromes	April 2001	Phase 2
NCT00002549	European Organisation for Research and Treatment of Cancer - EORTC\|National Cancer Institute (NCI)	Leukemia	November 1993	Phase 3
NCT00052299	European Organisation for Research and Treatment of Cancer - EORTC\|Gruppo Italiano Malattie EMatologiche dell´Adulto	Leukemia	September 2002	Phase 3
NCT00002517	European Organisation for Research and Treatment of Cancer - EORTC\|National Cancer Institute (NCI)	Leukemia\|Myelodysplastic Syndromes	March 1993	Phase 3
NCT05052970	CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.	Relapsed or Refractory Multiple Myeloma	October 20, 2021	Phase 1
NCT00010075	GERCOR - Multidisciplinary Oncology Cooperative Group\|National Cancer Institute (NCI)	Breast Cancer	January 2000	Phase 2
NCT00169208	Lymphoma Study Association	Follicular Lymphoma	April 2001	Phase 2
NCT05089461	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Malignant Tumor	March 7, 2022	Phase 2
NCT00003232	NCIC Clinical Trials Group\|Canadian Cancer Trials Group	Pain\|Prostate Cancer\|Quality of Life	November 24, 1997	Phase 3
NCT00002674	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Leukemia	October 1994	Phase 2
NCT00070174	Children´s Oncology Group\|National Cancer Institute (NCI)	Leukemia	December 2003	Phase 2
NCT04921878	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Advanced Solid Tumors	June 2021	Phase 1
NCT00744081	Johann Wolfgang Goethe University Hospital	AML	July 2004	Phase 2
NCT01842672	New York Medical College	Acute Lymphoblastic Leukemia\|Acute Myelogenous Leukemia\|Lymphoblastic Lymphoma\|Diffuse Large B-cell Lymphoma\|Burkitt Lymphoma+Leukemia	March 2013	Phase 1\|Phase 2
NCT00203073	Teva Branded Pharmaceutical Products R&D, Inc.	Relapsing Remitting Multiple Sclerosis	June 2003	Phase 2
NCT00004001	Southwest Oncology Group\|National Cancer Institute (NCI)\|Cancer and Leukemia Group B\|North Central Cancer Treatment Group	Prostate Cancer	October 1999	Phase 3
NCT00219908	Rennes University Hospital\|Bayer\|Wyeth is now a wholly owned subsidiary of Pfizer\|Farmades, Italy	Relapsing-Remitting Multiple Sclerosis	July 1999	Phase 2
NCT04195945	Fred Hutchinson Cancer Center\|Jazz Pharmaceuticals	Acute Myeloid Leukemia\|Myeloid Neoplasm	March 11, 2020	Phase 2
NCT03983824	National Cancer Institute (NCI)	Recurrent Acute Myeloid Leukemia\|Refractory Acute Myeloid Leukemia	October 4, 2019	Phase 1
NCT01700946	St. Jude Children´s Research Hospital\|Cookies for Kids´ Cancer\|Assisi Foundation	Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia\|Recurrent Childhood B-Lymphoblastic Lymphoma	April 15, 2013	Phase 2
NCT00006045	Facet Biotech\|National Cancer Institute (NCI)	Leukemia	March 2000	Phase 3
NCT01127009	Case Comprehensive Cancer Center	Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Recurrent Adult Acute Myeloid Leukemia	July 2010	Phase 1
NCT03441048	Medical College of Wisconsin	Acute Myeloid Leukemia	May 22, 2018	Phase 1
NCT00005987	Masonic Cancer Center, University of Minnesota	Multiple Myeloma and Plasma Cell Neoplasm	August 2000	Phase 2
NCT04718376	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Platinum-resistant Ovarian Cancer	January 12, 2021	Phase 1
NCT00006114	GERCOR - Multidisciplinary Oncology Cooperative Group\|National Cancer Institute (NCI)	Prostate Cancer	May 1999	Phase 2
NCT02597153	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Relapsed Cutaneous T Cell Lymphom	October 2015	Phase 2
NCT02724163	University of Birmingham\|Assistance Publique - Hôpitaux de Paris\|Cancer Research UK\|National Cancer Institute, France\|Pfizer	Acute Myeloid Leukaemia	April 2016	Phase 3
NCT00002658	Medical Research Council\|National Cancer Institute (NCI)	Leukemia\|Neutropenia	January 1994	Phase 3
NCT00003080	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Ovarian Cancer	September 1996	Phase 1
NCT05620862	Sun Yat-sen University\|CSPC Ouyi Pharmaceutical Co., Ltd.	Lymphoma, Solid Tumors	October 25, 2022	Phase 1
NCT05330377	Ayman H Qasrawi\|Astellas Pharma Inc\|University of Kentucky	Acute Myeloid Leukemia	March 2023	Phase 1
NCT00002498	Leiden University Medical Center\|National Cancer Institute (NCI)	Breast Cancer	July 1992	Phase 2
NCT00005847	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)	Prostate Cancer	January 2001	Phase 2
NCT01184898	Sidney Kimmel Cancer Center at Thomas Jefferson University\|University of Pennsylvania\|Thomas Jefferson University	AML	July 2010	Not Applicable
NCT04900766	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Unresectable or Metastatic Bone and Soft Tissue Sarcoma	June 2021	Phase 1
NCT00385827	Centocor, Inc.	Cancer, Prostate	November 2006	Phase 2
NCT00002700	European Organisation for Research and Treatment of Cancer - EORTC\|Acute Leukemia French Association	Leukemia\|Lymphoma	August 1995	Phase 3
NCT00002598	Memorial Sloan Kettering Cancer Center	Leukemia	June 1994	Phase 2
NCT01801046	University of Southern California\|National Cancer Institute (NCI)	Adult Acute Megakaryoblastic Leukemia (M7)\|Adult Acute Monoblastic Leukemia (M5a)\|Adult Acute Monocytic Leukemia (M5b)\|Adult Acute Myeloblastic Leukemia With Maturation (M2)\|Adult Acute Myeloblastic Leukemia Without Maturation (M1)\|Adult Acute Myeloid Leukemia in Remission\|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities\|Adult Acute Myeloid Leukemia With Del(5q)\|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)\|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)\|Adult Acute Myelomonocytic Leukemia (M4)\|Adult Erythroleukemia (M6a)\|Adult Pure Erythroid Leukemia (M6b)\|Childhood Acute Erythroleukemia (M6)\|Childhood Acute Megakaryocytic Leukemia (M7)\|Childhood Acute Monoblastic Leukemia (M5a)\|Childhood Acute Monocytic Leukemia (M5b)\|Childhood Acute Myeloblastic Leukemia With Maturation (M2)\|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)\|Childhood Acute Myeloid Leukemia in Remission\|Childhood Acute Myelomonocytic Leukemia (M4)\|Recurrent Adult Acute Myeloid Leukemia\|Recurrent Childhood Acute Myeloid Leukemia\|Secondary Acute Myeloid Leukemia\|Untreated Adult Acute Myeloid Leukemia\|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies	March 6, 2013	Phase 1
NCT03531918	Fred Hutchinson Cancer Center\|Pfizer	Acute Myeloid Leukemia	September 14, 2018	Phase 1\|Phase 2
NCT00024492	INSYS Therapeutics Inc	Tumors	August 2001	Phase 1
NCT02632708	Institut de Recherches Internationales Servier\|Celgene Corporation\|Servier	Newly Diagnosed Acute Myeloid Leukemia (AML)\|Untreated AML\|AML Arising From Myelodysplastic Syndrome (MDS)\|AML Arising From Antecedent Hematologic Disorder (AHD)\|AML Arising After Exposure to Genotoxic Injury	December 31, 2015	Phase 1
NCT02921061	Fred Hutchinson Cancer Center\|National Cancer Institute (NCI)	Mixed Phenotype Acute Leukemia\|Previously Treated Myelodysplastic Syndrome\|Recurrent Adult Acute Myeloid Leukemia\|Recurrent High Risk Myelodysplastic Syndrome\|Refractory Acute Myeloid Leukemia\|Refractory High Risk Myelodysplastic Syndrome\|Untreated Adult Acute Myeloid Leukemia	November 17, 2016	Phase 1\|Phase 2
NCT02070458	Case Comprehensive Cancer Center\|National Cancer Institute (NCI)	Recurrent Adult Acute Myeloid Leukemia\|Refractory Acute Myeloid Leukemia	October 8, 2014	Phase 1
NCT00683475	Eli Lilly and Company	Prostate Cancer	August 2008	Phase 2
NCT03860844	Sanofi	Acute Lymphoblastic Leukemia\|Acute Myeloid Leukemia	August 6, 2019	Phase 2
NCT00417079	Sanofi	Neoplasms\|Prostatic Neoplasms	January 2007	Phase 3
NCT05100303	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	Treatment-naive or Relapsed or Refractory Acute Myeloid Leukemia (AML)	December 2021	Phase 1\|Phase 2
NCT01403415	National Cancer Institute (NCI)	Childhood B Acute Lymphoblastic Leukemia\|Childhood T Acute Lymphoblastic Leukemia\|Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma\|Recurrent Childhood Acute Lymphoblastic Leukemia\|Recurrent Childhood Lymphoblastic Lymphoma	September 2011	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 140.61 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2498 mL	11.2491 mL	22.4982 mL
5 mM	0.4500 mL	2.2498 mL	4.4996 mL
10 mM	0.2250 mL	1.1249 mL	2.2498 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7.
[2] Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
[3] Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35(5):822-8.
[4] Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62.
[5] Sharon E Altmann, et al. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res. 2012 Feb;93(2):305-308.

Synonyms

9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione

NSC 279836

DHAQ

Dihydroxyanthraquinone

Mitoxantrone

Mitoxanthrone

1,4-Bis[(2-(2-hydroxyethylamino)ethyl)amino]-5,8-dihydroxyanthraquinone

Mitozantrone

1,4-Dihydroxy-5,8-bis-[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone

Novantron

Ralenova

Novantrone

Mitox

Nimitoxantron

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