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[CAS NO. 65893-94-9] GlabrescioneB
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-122590 |
| Brand: | MCE |
| CAS: | 65893-94-9 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 450.52 |
| Molecular Formula | C27H30O6 |
| SMILES | O=C1C(C2=CC=C(OC/C=C(C)/C)C(OC/C=C(C)/C)=C2)=COC3=CC(OC)=CC(OC)=C13 |
Summary
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1 . Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells [1] [2] .
IC50 & Target
Gli1-DNA Interaction [1]
In Vitro
Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma
[2]
.
Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | ASZ001 BCC cells |
| Concentration: | 5 μM |
| Incubation Time: | 24-72 hours |
| Result: | Basal cell carcinoma cell proliferation was impaired. |
Western Blot Analysis [1]
| Cell Line: | ASZ001 BCC cells |
| Concentration: | 1-10 μM |
| Incubation Time: | 24-48 hours |
| Result: | Gli1 mRNA expression levels was decreased. |
In Vivo
| Animal Model: | Female NOD/SCID mice (ASZ001 BCC allografts) [2] |
| Dosage: | 100 μmol/kg |
| Administration: | I.p.; every second day for 18 days |
| Result: | A significant reduction of tumor growth as well as Gli1 mRNA levels was observed. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 221.97 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2197 mL | 11.0983 mL | 22.1966 mL |
| 5 mM | 0.4439 mL | 2.2197 mL | 4.4393 mL |
| 10 mM | 0.2220 mL | 1.1098 mL | 2.2197 mL |
References
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