[CAS NO. 663212-78-0] NUCC-0000323

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PRODUCTS SPECIFICATIONS [663212-78-0]

Catelog

HY-153019

Brand

MCE

CAS

663212-78-0

DESCRIPTION [663212-78-0]

Overview

MDL	-
Molecular Weight	361.26
Molecular Formula	C15H13BrN4S
SMILES	BrC1=CC=C(CSC2=NN=C(N2C)C3=CC=NC=C3)C=C1

For research use only. We do not sell to patients.

Summary

NUCC-0000323 is a potent superoxide dismutase 1 (SOD1) inhibitor. NUCC-0000323 inhibits SOD1 expression. NUCC-0000323 can be used in research of amyotrophic lateral sclerosis (ALS) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 346.01 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7681 mL	13.8404 mL	27.6809 mL
5 mM	0.5536 mL	2.7681 mL	5.5362 mL
10 mM	0.2768 mL	1.3840 mL	2.7681 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.76 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.76 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.76 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Teepu S, et, al. Small molecule inhibitors of superoxide dismutase expression. US20150210679A1.