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[CAS NO. 66663-91-0] Polygalacin D
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-N6064 |
| Brand: | MCE |
| CAS: | 66663-91-0 |
Overview
| MDL | MFCD28009141 |
|---|---|
| Molecular Weight | 1209.32 |
| Molecular Formula | C57H92O27 |
| SMILES | O[C@H]([C@@H]([C@@H](O[C@@]1([H])[C@@H]([C@H]([C@H](O)CO1)O[C@@]2([H])[C@@H]([C@](CO)(O)CO2)O)O)[C@H](C)O3)O)[C@]3([H])O[C@H]([C@H]([C@@H](O)CO4)O)[C@@H]4OC([C@]56[C@](CC(C)(C)CC6)([H])C7=CC[C@@]([C@@]8([C@@]([C@](C)([C@@H](O[C@]9([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]9O)CO)[C@@H](O)C8)CO)([H])CC%10)C)([H])[C@]%10(C)[C@]7(C)C[C@H]5O)=O |
1 Publications Citing Use of MCE
Summary
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin , cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K . Polygalacin D induces apoptosis [1]
IC50 & Target
IC50: IAP [1]
In Vitro
Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC
50
s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells
[1]
.
Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells
[1]
.
Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | A549 and H460 cancer cell lines |
| Concentration: | 10 µM, 20 µM, 40µM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the proliferation of NSCLC cell lines. |
Apoptosis Analysis [1]
| Cell Line: | A549 and H460 cancer cell lines |
| Concentration: | 10 µM, 20 µM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis of NSCLC cell lines. |
Western Blot Analysis [1]
| Cell Line: | A549 and H460 cancer cell lines |
| Concentration: | 10 µM, 20 µM |
| Incubation Time: | 48 hours |
| Result: | Decreased survivin, c-IAP-1 and c-IAP-2 expression. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 82.69 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.8269 mL | 4.1346 mL | 8.2691 mL |
| 5 mM | 0.1654 mL | 0.8269 mL | 1.6538 mL |
| 10 mM | 0.0827 mL | 0.4135 mL | 0.8269 mL |
Synonyms
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