[CAS NO. 666843-10-3] Mizagliflozin

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PRODUCTS SPECIFICATIONS [666843-10-3]

Catalog

HY-17638

Brand

MCE

CAS

666843-10-3

DESCRIPTION [666843-10-3]

Overview

MDL	-
Molecular Weight	564.67
Molecular Formula	C28H44N4O8
SMILES	O=C(N)C(C)(C)CNCCCOC1=CC=C(CC2=C(C(C)C)NN=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(C)=C1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Nat Biomed Eng. 2022 Jul;6(7):867-881.

Summary

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a K _i of 27 nM for human SGLT1 . Mizagliflozin displays 303-fold selectivity over SGLT2 . Mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation ^[1] .

IC50 & Target

Ki: 27 nM (hSGLT1), 8170 nM (hSGLT2) ^[1]

In Vivo

Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect ^[1] .
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively) ^[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (rat model of low-fiber-diet-induced constipation) ^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	Oral
Result:	Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05541939	Vogenx, Inc.	Postbariatric Hypoglycemia	September 13, 2022	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H ₂ O : ≥ 100 mg/mL ( 177.09 mM )

DMSO : 100 mg/mL ( 177.09 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7709 mL	8.8547 mL	17.7095 mL
5 mM	0.3542 mL	1.7709 mL	3.5419 mL
10 mM	0.1771 mL	0.8855 mL	1.7709 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution

* All of the co-solvents are available by MCE.