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[CAS NO. 67-71-0] Dimethyl sulfone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-Y1314 |
| Brand: | MCE |
| CAS: | 67-71-0 |
Overview
| MDL | MFCD00007566 |
|---|---|
| Molecular Weight | 94.13 |
| Molecular Formula | C2H6O2S |
| SMILES | O=S(C)(C)=O |
1 Publications Citing Use of MCE
Summary
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective [1] [2] [3] .
IC50 & Target
|
Microbial Metabolite
|
Human Endogenous Metabolite
|
In Vitro
Dimethyl sulfone (25 mM/mL for 15.5 μL/mL; 24 h) inhibits the proliferation of cultured bovine choriocapillary endothelial (CCE) cells
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dimethyl sulfone (for 0, 0.01, 0.03, 0.1, 0.3 and 1.0 mL; i.p.; single dose) shows neuroprotective effect with significant infarction volume reduction in ischemia rats
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 50 mg/mL ( 531.18 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 10.6236 mL | 53.1180 mL | 106.2361 mL |
| 5 mM | 2.1247 mL | 10.6236 mL | 21.2472 mL |
| 10 mM | 1.0624 mL | 5.3118 mL | 10.6236 mL |
References
- [1] Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Dimethyl Sulfone. 2022 Mar 21.
- [2] Eter N, et al. DMSO mimics inhibitory effect of thalidomide on choriocapillary endothelial cell proliferation in culture. Br J Ophthalmol. 2002 Nov;86(11):1303-5.
- [3] Shimizu S, et al. Dimethylsulfoxide (DMSO) treatment reduces infarction volume after permanent focal cerebral ischemia in rats. Neurosci Lett. 1997 Dec 19;239(2-3):125-7.
Synonyms
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