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[CAS NO. 672-87-7] Metyrosine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-W015007 |
| Brand: | MCE |
| CAS: | 672-87-7 |
Overview
| MDL | MFCD00064201 |
|---|---|
| Molecular Weight | 195.22 |
| Molecular Formula | C10H13NO3 |
| SMILES | C[C@](C(O)=O)(N)CC1=CC=C(O)C=C1 |
Summary
In Vitro
Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation
[1]
.
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male albino Wistar rats (carrageenan-induced rat paw edema) [2] |
| Dosage: | 50, 100 or 200 mg/kg |
| Administration: | I.p. |
| Result: | Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h). |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01127503 | Bausch Health Americas, Inc. |
Velo-cardio-facial Syndrome|Psychosis
|
June 2010 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 5 mg/mL ( 25.61 mM ; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.1224 mL | 25.6121 mL | 51.2243 mL |
| 5 mM | 1.0245 mL | 5.1224 mL | 10.2449 mL |
| 10 mM | 0.5122 mL | 2.5612 mL | 5.1224 mL |
References
- [1] Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119.
- [2] Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336.
Synonyms
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