[CAS NO. 67219-55-0] N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

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PRODUCTS SPECIFICATIONS [67219-55-0]

Catelog

HY-W010706

Brand

MCE

CAS

67219-55-0

DESCRIPTION [67219-55-0]

Overview

MDL	MFCD00010114
Molecular Weight	633.69
Molecular Formula	C37H35N3O7
SMILES	O=C(N=C(NC(C1=CC=CC=C1)=O)C=C2)N2[C@H]3C[C@H](O)[C@@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)O3

For research use only. We do not sell to patients.

Summary

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 157.81 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5781 mL	7.8903 mL	15.7806 mL
5 mM	0.3156 mL	1.5781 mL	3.1561 mL
10 mM	0.1578 mL	0.7890 mL	1.5781 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (3.95 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.95 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] James W Gaynor, et al. Synthesis of the 3'-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage. Nat Protoc. 2007;2(12):3122-35.

Synonyms

Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-

Cytidine, N-benzoyl-5′-O-[α,α-bis(p-methoxyphenyl)benzyl]-2′-deoxy-

N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine

N-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine

N⁴-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine